2013
Increasing dietary protein selectively upregulates the DMT1 isoform that contains an iron responsive element
Thomas C, Yao G, O'Brien K, Kerstetter J, Insogna K. Increasing dietary protein selectively upregulates the DMT1 isoform that contains an iron responsive element. The FASEB Journal 2013, 27: lb284-lb284. DOI: 10.1096/fasebj.27.1_supplement.lb284.Peer-Reviewed Original ResearchIntestinal iron absorptionIron absorptionDietary proteinProtein dietMRNA expressionWhole-body iron homeostasisDuodenum of ratsDMT1 mRNA expressionBody iron homeostasisGenetic absenceExperimental animalsLevel of expressionResponsive elementBrush border membraneRatsIron-responsive elementRecent dataDietCritical regulatorIron homeostasisBorder membraneSignificant changesExpressionIron importerAnimalsDifferential effects of hepcidin on heme and nonheme iron absorption in a rat model of iron overload
Cao C, Thomas C, Insogna K, O'Brien K. Differential effects of hepcidin on heme and nonheme iron absorption in a rat model of iron overload. The FASEB Journal 2013, 27: 634.18-634.18. DOI: 10.1096/fasebj.27.1_supplement.634.18.Peer-Reviewed Original ResearchFe overloadMale Sprague-Dawley ratsWeeks of treatmentFe absorptionBi-weekly injectionsNonheme iron absorptionRed cell incorporationSprague-Dawley ratsLiver hepcidinDawley ratsRat modelRats inhibitsIron overloadRodent modelsIron absorptionAlternate daysRegulatory hormonesHepcidin transcriptsHepcidinFpn degradationRatsCell incorporationGreater associationDifferential effectsPorcine RBCsIncreasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats
Thomas CE, Gaffney‐Stomberg E, Sun B, O'Brien KO, Kerstetter JE, Insogna KL. Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats. The FASEB Journal 2013, 27: 2476-2483. PMID: 23447582, DOI: 10.1096/fj.12-221945.Peer-Reviewed Original ResearchConceptsIntestinal Fe absorptionDietary proteinFe absorptionIron transporter expressionTranscript expressionDuodenal mucosaAcute effectsSprague-DawleyStable iron isotopesIron absorptionShort-term effectsIsocaloric dietsIron deficiencyTransporter expressionLittle dataTransferrin receptorExpression of genesSeparate studiesGroupCurrent studyBalance studiesExpressionWhole genome profilingDawleyMucosa
2011
Dietary protein upregulates fractional intestinal iron absorption and directly increases DMT1 transcript and protein expression
Cucchi C, Gaffney‐Stomberg E, Sun B, O'Brien K, Kerstetter J, Insogna K. Dietary protein upregulates fractional intestinal iron absorption and directly increases DMT1 transcript and protein expression. The FASEB Journal 2011, 25: lb193-lb193. DOI: 10.1096/fasebj.25.1_supplement.lb193.Peer-Reviewed Original ResearchProtein dietDietary proteinProtein expressionCaco-2 BBe cellsIntestinal Fe absorptionFe absorption studiesIntestinal iron absorptionTranscript expressionAmino acid-free mediumDMT1 protein levelsAmino acid treatmentDMT1 protein expressionProtein doseIron absorptionBBE cellsIron deficiencyAcid-free mediumRatsProtein levelsDietDMT1 transcriptsAmino acidsFe absorptionWestern analysisKey regulator
2010
A High Protein Diet Induces Intestinal Iron Transporter Expression and Improves Iron Absorption in Rats
Cucchi C, Gaffney‐Stomberg E, Sun B, Kerstetter J, Insogna K. A High Protein Diet Induces Intestinal Iron Transporter Expression and Improves Iron Absorption in Rats. The FASEB Journal 2010, 24: 229.1-229.1. DOI: 10.1096/fasebj.24.1_supplement.229.1.Peer-Reviewed Original ResearchDietary proteinIron absorptionTransporter expressionHigh casein dietExpression of DMT1Iron transporter expressionFe absorptionVs. 5Kruskal-Wallis testMicroarray screenCasein dietMineral homeostasisLevel of expressionProtein dietRatsLittle dataDMT1 expressionQ-PCRDietBalance studiesExpressionHomeostasisGroupDMT1CYBRD1
2009
Iron-Refractory Iron Deficiency Anemia
Finberg KE. Iron-Refractory Iron Deficiency Anemia. Seminars In Hematology 2009, 46: 378-386. PMID: 19786206, DOI: 10.1053/j.seminhematol.2009.06.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdministration, OralAnemia, Iron-DeficiencyAnemia, RefractoryAntimicrobial Cationic PeptidesChildChild, PreschoolFemaleGPI-Linked ProteinsHematinicsHemochromatosis ProteinHepcidinsHumansInfantInfusions, ParenteralIronIron CompoundsLiverMaleMembrane ProteinsMutationSerine EndopeptidasesTreatment FailureUp-RegulationConceptsIron-refractory iron deficiency anemiaIron deficiency anemiaDeficiency anemiaOral iron treatmentParenteral iron therapyAutosomal recessive disorderIron therapyClinical presentationRecent studiesHepcidin expressionIron absorptionIRIDA patientsTransmembrane serine proteaseIron treatmentAnemiaElevated levelsRecessive disorderHepcidinLiverDisordersTMPRSS6Serine proteases
2000
Localization, allelic heterogeneity, and origins of the hemochromatosis gene
Raha-Chowdhury R, Gruen J. Localization, allelic heterogeneity, and origins of the hemochromatosis gene. 2000, 75-90. DOI: 10.1017/cbo9780511666476.008.Peer-Reviewed Original ResearchMajor histocompatibility complexHemochromatosis geneIron absorptionDisease of adultsHLA class IExcessive iron absorptionEnhanced iron absorptionCommon autosomal recessive disorderAutosomal recessive disorderNeonatal hemochromatosisOrgan damageChildhood onsetFifth decadeClinical heterogeneityHLAHemochromatosisIntroduction HemochromatosisIron accumulationHistocompatibility complexClass IRecessive disorderDiseaseDifferent diseasesVariables ageChromosomal translocations
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