2023
Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats
Hassan Z, Singh D, Suhaimi F, Chear N, Harun N, See C, Kaur G, Mat N, Bakar S, Yusof N, Kasinather V, Chawarski M, Murugaiyah V, Ramanathan S. Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats. Regulatory Toxicology And Pharmacology 2023, 143: 105466. PMID: 37536550, DOI: 10.1016/j.yrtph.2023.105466.Peer-Reviewed Original ResearchConceptsDays of treatmentToxicity profileFemale Sprague-Dawley ratsOpioid replacement therapyLow platelet countEnd of treatmentSprague-Dawley ratsEvidence of toxicityOccurrence of mortalityPlatelet countDawley ratsHematology profileBody weightMitragyna speciosa KorthBrain tissueHistopathology analysisHistological investigationHerbal drug preparationsDecoctionUric acidDrug preparationTherapeutic propertiesKidneyMortalityRats
2022
Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer
Glass E, Hoover A, Bullock K, Madden M, Reinfeld B, Harris W, Parker D, Hufnagel D, Crispens M, Khabele D, Rathmell W, Rathmell J, Wilson A, Giorgio T, Yull F. Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer. BMC Cancer 2022, 22: 497. PMID: 35513776, PMCID: PMC9074180, DOI: 10.1186/s12885-022-09612-2.Peer-Reviewed Original ResearchConceptsTumor-associated macrophagesAnti-tumor immunityOvarian cancerConsecutive days' treatmentTumor burdenMouse modelSolid tumorsImmunosuppressive tumor-associated macrophagesAnti-tumor phenotypeLate-stage diseaseClear therapeutic effectImmune cell compositionImmunosuppressive tumor microenvironmentM1 macrophage polarizationStrong translational potentialOvarian cancer modelFuture clinical studiesNF-κB alphaOvarian cancer progressionHigh response rateNF-κB activityEvidence of toxicityNuclear factor-kappaBInducible transgenic miceID8 model
2006
The Effect of High-Dose Vitamin D Supplementation on Serum Vitamin D Levels and Milk Calcium Concentration in Lactating Women and Their Infants
Basile LA, Taylor SN, Wagner CL, Horst RL, Hollis BW. The Effect of High-Dose Vitamin D Supplementation on Serum Vitamin D Levels and Milk Calcium Concentration in Lactating Women and Their Infants. Breastfeeding Medicine 2006, 1: 27-35. PMID: 17661558, DOI: 10.1089/bfm.2006.1.27.Peer-Reviewed Original ResearchMeSH KeywordsAdultBone Density Conservation AgentsCalciumCreatinineDietary SupplementsDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansInfantInfant Nutritional Physiological PhenomenaInfant, NewbornLactationMaternal Nutritional Physiological PhenomenaMilk, HumanNutritional RequirementsNutritional StatusProspective StudiesVitamin DVitamin D DeficiencyConceptsVitamin D statusMilk calcium concentrationD statusBreast milkVitamin DDay regimenIU/day vitamin DHigh-dose vitamin D supplementationBreast-milk calcium concentrationHigh-dose vitamin DImproved vitamin D statusMaternal vitamin D statusOptimal vitamin D statusSerum vitamin D levelsUrinary Ca/Cr ratioCa/Cr ratioCalcium concentrationInfant serum levelsVitamin D doseVitamin D levelsVitamin D supplementationEvidence of toxicityD regimenD supplementationAdverse events
1993
Effects of intrasphincteric botulinum toxin on the lower esophageal sphincter in piglets
Pasricha P, Ravich W, Kalloo A. Effects of intrasphincteric botulinum toxin on the lower esophageal sphincter in piglets. Gastroenterology 1993, 105: 1045-1049. PMID: 8405847, DOI: 10.1016/0016-5085(93)90947-b.Peer-Reviewed Original ResearchConceptsLES pressureLower esophageal sphincter pressureIntrasphincteric botulinum toxinEsophageal sphincter pressureLower esophageal sphincterRelease of acetylcholineGastrointestinal smooth muscleNormal saline injectionEvidence of toxicityBaseline lower esophageal sphincter pressureBoTx injectionNoncholinergic pathwaysAnticholinergic effectsSphincter pressureLES toneEsophageal sphincterGastrointestinal sphinctersBotulinum toxinNormal salineSaline injectionNerve terminalsParadoxical responseSmooth muscleBoTxSkeletal muscle
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