2025
Diagnosis of cancer therapy-related cardiovascular toxicities: A multimodality integrative approach and future developments
Travers S, Alexandre J, Baldassarre L, Salem J, Mirabel M. Diagnosis of cancer therapy-related cardiovascular toxicities: A multimodality integrative approach and future developments. Archives Of Cardiovascular Diseases 2025, 118: 185-198. PMID: 39947997, DOI: 10.1016/j.acvd.2024.12.012.Peer-Reviewed Original ResearchConceptsCardio-OncologyCardiovascular toxicityCardiovascular imagingMultimodality cardiovascular imagingCancer risk factorsIncrease diagnostic accuracyPrognostic stratificationNatriuretic peptideSerum biomarkersTherapy schemesDiagnostic accuracyCancer therapyRhythm disordersRisk factorsCardiovascular diseaseBiomarkersMultimodal integrated approachCancerOmics approachesToxicityRhythmTherapyTroponinSerumDiagnosisHow to Use Imaging: Complex Cases of Atherosclerosis, Myocardial Inflammation, and Cardiomyopathy in Cardio-Oncology
Khattab M, Baig M, Zarif T, Barac A, Ferencik M, Henry M, Lopez-Mattei J, Redheuil A, Salem J, Scherrer-Crosbie M, Yang E, Baldassarre L. How to Use Imaging: Complex Cases of Atherosclerosis, Myocardial Inflammation, and Cardiomyopathy in Cardio-Oncology. Circulation Cardiovascular Imaging 2025, 18: e015981. PMID: 39772610, DOI: 10.1161/circimaging.124.015981.Peer-Reviewed Original ResearchConceptsCardio-OncologyCases of atherosclerosisCardiac magnetic resonance imagingCoronary Computed Tomography AngiographySingle-photon Emission Computed TomographyImmune checkpoint inhibitorsLeft ventricular dysfunctionMultimodality cardiac imagingTyrosine kinase inhibitorsCardiac imaging modalitiesComputed tomography angiographyRisk of cardiovascular diseaseEmission Computed TomographyPositron emission tomographyMagnetic resonance imagingCheckpoint inhibitorsVentricular dysfunctionMyocardial inflammationCoronary vasospasmAccelerated atherosclerosisKinase inhibitorsPatient populationDiagnosing such pathologiesCancer therapyCardiac imagingChapter 6 Cardio-oncology in the digital era
El-Mais I, Maddula R, Cao X, Nona P. Chapter 6 Cardio-oncology in the digital era. 2025, 125-140. DOI: 10.1016/b978-0-443-29829-5.00018-9.Peer-Reviewed Original ResearchDigital healthImprove care deliveryOptimal health careCardio-OncologyDigital eraCare deliveryHealth careCardiovascular careIncrease preventionCareHealthCardio-oncology careDecision-support toolEthical considerationsDigital technologiesWearable technologyLandscape challengesEvolving digital eraTelehealthEra
2024
Advanced Imaging Modalities in Cardiotoxicity: The Roles of Cardiac CT, MRI, and PET in Cardio-oncology
Arbune A, Khattab M, Henry M, Baldassarre L. Advanced Imaging Modalities in Cardiotoxicity: The Roles of Cardiac CT, MRI, and PET in Cardio-oncology. Current Treatment Options In Cardiovascular Medicine 2024, 27: 5. DOI: 10.1007/s11936-024-01061-3.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsBaseline risk stratificationCardiac computed tomographyCardiac magnetic resonanceAdvanced cardiac imaging modalitiesPositron emission tomographyCardiac imaging modalitiesCoronary artery calciumRisk stratificationCardio-OncologyImaging modalitiesCardiac massEvaluate immune checkpoint inhibitorsImmune checkpoint inhibitor myocarditisImmune checkpoint inhibitor therapyAdvanced cardiac imaging techniquesCardiac positron emission tomographyDiagnosis of cardiotoxicityNoninvasive diagnostic testCardiac imaging techniquesRisk stratification toolCardio-oncology patientsAdvanced imaging modalitiesCoronary flow reserveImaging techniquesCardiovascular Considerations During Cancer Therapy Gaps in Evidence and JACC: CardioOncology Expert Panel Recommendations
Leong D, Waliany S, Abdel-Qadir H, Atkins K, Neilan T, Lang N, Liu J, Blaes A, Mian H, Moore H, Hajjar L, Morgans A, Ellis P, Dent S. Cardiovascular Considerations During Cancer Therapy Gaps in Evidence and JACC: CardioOncology Expert Panel Recommendations. JACC CardioOncology 2024, 6: 815-834. PMID: 39801647, PMCID: PMC11711816, DOI: 10.1016/j.jaccao.2024.06.005.Peer-Reviewed Original ResearchCardiovascular toxicityCancer therapyContinuation of cancer therapySpectrum of toxicityDiverse health care professionalsExpert panelSevere cardiovascular diseaseHealth care professionalsExpert panel recommendationsCardiovascular ConsiderationsCardio-OncologyInvasive managementTherapy gapAdvanced cancerPrimary preventionTherapyCancerCardiovascular diseaseCardiovascular treatmentCare professionalsCardiovascular carePanel recommendationsPatientsToxicityTreatmentAdverse social determinants of health elevate uncontrolled hypertension risk: a cardio-oncology prospective cohort study
Nain P, Stabellini N, Makram O, Rast J, Yerraguntla S, Gopu G, Bhave A, Seth L, Patel V, Jiang S, Malik S, Shetewi A, Montero A, Cullen J, Agarwal N, Wang X, Ky B, Baldassarre L, Weintraub N, Harris R, Guha A. Adverse social determinants of health elevate uncontrolled hypertension risk: a cardio-oncology prospective cohort study. JNCI Cancer Spectrum 2024, 8: pkae064. PMID: 39115393, PMCID: PMC11368120, DOI: 10.1093/jncics/pkae064.Peer-Reviewed Original ResearchSocial determinants of healthSocial determinants of health scoreSocial determinantsAdverse SDHImpact of social determinants of healthUncontrolled hypertensionAdverse social determinantsDeterminants of healthRisk of uncontrolled hypertensionProspective cohort studyCardio-oncology clinicCancer patientsBlood pressure readingsHypertension riskHypertension controlCohort studySocial isolationUrban residentsClinic blood pressure readingsControlled hypertensionIncreased riskProspective study patientsCox regressionCardio-OncologyHealth
2023
Advancing the care of individuals with cancer through innovation & technology: Proceedings from the cardiology oncology innovation summit 2020 and 2021
Brown S, Beavers C, Bauer B, Cheng R, Berman G, Marshall C, Guha A, Jain P, Steward A, DeCara J, Olaye I, Hansen K, Logan J, Bergom C, Glide-Hurst C, Loh I, Gambril J, MacLeod J, Maddula R, McGranaghan P, Batra A, Campbell C, Hamid A, Gunturkun F, Davis R, Jefferies J, Fradley M, Albert K, Blaes A, Choudhuri I, Ghosh A, Ryan T, Ezeoke O, Leedy D, Williams W, Roman S, Lehmann L, Sarkar A, Sadler D, Polter E, Ruddy K, Bansal N, Yang E, Patel B, Cho D, Bailey A, Addison D, Rao V, Levenson J, Itchhaporia D, Watson K, Gulati M, Williams K, Lloyd-Jones D, Michos E, Gralow J, Martinez H. Advancing the care of individuals with cancer through innovation & technology: Proceedings from the cardiology oncology innovation summit 2020 and 2021. American Heart Journal Plus Cardiology Research And Practice 2023, 38: 100354. PMID: 38510746, PMCID: PMC10945974, DOI: 10.1016/j.ahjo.2023.100354.Peer-Reviewed Original ResearchCare of individualsQuality of lifeEducation sessionsPatient's life expectancyCardiovascular healthcareAligning resourcesLife expectancyCardio-OncologyCancer patientsLong-term cardiovascular toxicityCross-collaborationEducationCardiologyAcademic institutionsCancerPatientsCareHealthcareCollaborationSurvivors
2022
Ten step academic-industry digital health collaboration methodology: A case-based guide for digital health research teams with the example of cardio-oncology
MacLeod J, Abdelrahim M, Painter S, Maddula R, Steward A, Hamid A, Cheng R, Zaha V, Addison D, Bauer B, Brown S. Ten step academic-industry digital health collaboration methodology: A case-based guide for digital health research teams with the example of cardio-oncology. Frontiers In Cardiovascular Medicine 2022, 9: 982059. PMID: 36247469, PMCID: PMC9562627, DOI: 10.3389/fcvm.2022.982059.Peer-Reviewed Original ResearchCardiac computed tomographic imaging in cardio-oncology: An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT). Endorsed by the International Cardio-Oncology Society (ICOS)
Lopez-Mattei J, Yang EH, Baldassarre LA, Agha A, Blankstein R, Choi AD, Chen MY, Meyersohn N, Daly R, Slim A, Rochitte C, Blaha M, Whelton S, Dzaye O, Dent S, Milgrom S, Ky B, Iliescu C, Mamas MA, Ferencik M. Cardiac computed tomographic imaging in cardio-oncology: An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT). Endorsed by the International Cardio-Oncology Society (ICOS). Journal Of Cardiovascular Computed Tomography 2022, 17: 66-83. PMID: 36216699, DOI: 10.1016/j.jcct.2022.09.002.Peer-Reviewed Original ResearchConceptsCardio-OncologyCardiac CTCardio-oncology patientsExpert consensus statementCardiovascular Computed TomographyExpert consensus documentConsensus statementComputed tomographyCurrent evidenceConsensus documentMultimodality imagingPractice recommendationsRadiation oncologyCCT applicationMultidisciplinary collaborationOncologyTomographic imagingImagingPatientsLimited guidanceCardiacCliniciansCardiologyCTCareConnected Health Innovation Research Program (C.H.I.R.P.): A bridge for digital health and wellness in cardiology and oncology
Maddula R, MacLeod J, Painter S, McLeish T, Steward A, Rossman A, Hamid A, Ashwath M, Martinez H, Guha A, Patel B, Addison D, Blaes A, Choudhuri I, Brown S. Connected Health Innovation Research Program (C.H.I.R.P.): A bridge for digital health and wellness in cardiology and oncology. American Heart Journal Plus Cardiology Research And Practice 2022, 20: 100192. PMID: 37800118, PMCID: PMC10552440, DOI: 10.1016/j.ahjo.2022.100192.Peer-Reviewed Original ResearchDigital health toolsHealth toolsCardiovascular healthDigital healthElectronic health recordsDigital health technologiesCancer survivorsInterdisciplinary research teamHealth recordsAssessment of adoptionOncology populationHealth technologiesGeneral populationHealthOncology patientsVideo modulesResearch teamCardio-OncologyHeart diseaseInterdisciplinary research platformHeart rate variabilityOncologyCollaborative foundationTeamSleep patterns
2021
Modeling Precision Cardio-Oncology: Using Human-Induced Pluripotent Stem Cells for Risk Stratification and Prevention
Perry T, Roberts M, Sunkara B, Maddula R, McLeish T, Gomez J, Lucas J, Rayan D, Patel S, Liang M, Bosnjak Z, Brown S. Modeling Precision Cardio-Oncology: Using Human-Induced Pluripotent Stem Cells for Risk Stratification and Prevention. Current Oncology Reports 2021, 23: 77. PMID: 33937943, PMCID: PMC8088904, DOI: 10.1007/s11912-021-01066-2.Peer-Reviewed Original ResearchConceptsHuman induced pluripotent stem cellsHuman induced pluripotent stem cell modelsTyrosine kinase inhibitorsCardiovascular toxicityBody mass indexCardio-OncologyPluripotent stem cellsManagement of cardiovascular toxicityMechanisms of cardiovascular toxicityMultidisciplinary team of cardiologistsCancer therapyRisk factorsStem cellsCardiovascular diseaseHuman epidermal growth factor receptorManagement of modifiable risk factorsPatient-specific cardiomyocytesEpidermal growth factor receptorPatient-specific treatment plansTeam of cardiologistsGrowth factor receptorCardiovascular risk factorsModifiable risk factorsCancer therapeutic agentsReduce cardiovascular diseaseA virtual-hybrid approach to launching a cardio-oncology clinic during a pandemic
Brown S, Patel S, Rayan D, Zaharova S, Lin M, Nafee T, Sunkara B, Maddula R, MacLeod J, Doshi K, Meskin J, Marks D, Saucedo J. A virtual-hybrid approach to launching a cardio-oncology clinic during a pandemic. Cardio-Oncology 2021, 7: 2. PMID: 33441188, PMCID: PMC7803880, DOI: 10.1186/s40959-020-00088-2.Peer-Reviewed Original ResearchCardio-oncology clinicIn-personCardio-OncologyIn-person careTeam of cliniciansAncillary support staffCancer patients/survivorsCancer survivorsCare spectrumReferral processClinical pharmacistsOutpatient referralsPreventive cardiologyReview of outcomesSynthesis of dataClinical sessionsGeneral cardiologySupport staffCardiovascular diagnosisReferralRetrospective reviewCardiovascular diseaseRetrospective review of outcomesBreast cancerClinic
2020
Cardiovascular Care of the Oncology Patient During COVID-19: An Expert Consensus Document From the ACC Cardio-Oncology and Imaging Councils
Baldassarre LA, Yang EH, Cheng RK, DeCara JM, Dent S, Liu JE, Rudski LG, Strom JB, Thavendiranathan P, Barac A, Zaha VG, Bucciarelli-Ducci C, Ellahham S, Deswal A, Lenneman C, Villarraga HR, Blaes AH, Ismail-Khan R, Ky B, Leja MJ, Scherrer-Crosbie M. Cardiovascular Care of the Oncology Patient During COVID-19: An Expert Consensus Document From the ACC Cardio-Oncology and Imaging Councils. Journal Of The National Cancer Institute 2020, 113: 513-522. PMID: 33179744, PMCID: PMC7717327, DOI: 10.1093/jnci/djaa177.Peer-Reviewed Original ResearchConceptsCardio-OncologyCardiovascular careCOVID-19Cardio-oncology patientsPrior cancer historyExpert consensus statementCoronavirus disease 2019 (COVID-19) pandemicExpert consensus documentRisk of infectionDisease 2019 pandemicCardiotoxicity surveillanceCardiovascular complicationsPericardial involvementLethal complicationCardiac dysfunctionOncology patientsRisk of exposureCancer historyCancer patientsCardiovascular diseaseConsensus statementAmerican CollegeCardiovascular treatmentConsensus documentPatients
2018
The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection—evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology
Davidson S, Arjun S, Basalay M, Bell R, Bromage D, Bøtker H, Carr R, Cunningham J, Ghosh A, Heusch G, Ibanez B, Kleinbongard P, Lecour S, Maddock H, Ovize M, Walker M, Wiart M, Yellon D. The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection—evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology. Basic Research In Cardiology 2018, 113: 43. PMID: 30310998, PMCID: PMC6182684, DOI: 10.1007/s00395-018-0704-z.Peer-Reviewed Original ResearchConceptsRemote ischaemic conditioningST-segment elevation myocardial infarctionIschaemic strokeLethal cell injuryMyocardial infarctionTherapies targeting specific pathwaysCell injuryLeft ventricular dysfunctionInstitute workshopAcute myocardial infarctionElevation myocardial infarctionLoss of cardiomyocytesVentricular dysfunctionReperfusion therapyHeart failureCardio-OncologyClinical settingIschaemic conditionsCancer therapyClinical scenariosContractile cardiomyocytesProgram of cell deathStrokeCardiomyocytesInfarction
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