2024
Clinicopathologic Characteristics of MYC Copy Number Amplification in Breast Cancer
Sun T, Golestani R, Zhan H, Krishnamurti U, Harigopal M, Zhong M, Liang Y. Clinicopathologic Characteristics of MYC Copy Number Amplification in Breast Cancer. International Journal Of Surgical Pathology 2024, 33: 59-64. PMID: 38839260, DOI: 10.1177/10668969241256109.Peer-Reviewed Original ResearchBreast cancerCopy number amplificationClinicopathological characteristicsAssociation with <i>TP53</i> mutation. InAssociated with invasive ductal carcinomaEstrogen receptor (ER)-negativeDisease-free survival timeGene copy number amplificationC-myc immunostainingNon-amplified tumorsTP53</i> mutationsTriple-negative statusMetastatic breast cancerInvasive ductal carcinomaMYC protein overexpressionBreast cancer patientsTriple-negativeDuctal carcinomaClinicopathological featuresGenetic abnormalitiesClinical dataImmunohistochemical studiesCancer patientsProtein overexpressionSurvival time
2023
Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia
Zheng Y, Xu C, Sun J, Ming W, Dai S, Shao Y, Qiu X, Li M, Shen C, Xu J, Fei F, Fang J, Jiang X, Zheng G, Hu W, Wang Y, Wang S, Ding M, Chen Z. Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia. Signal Transduction And Targeted Therapy 2023, 8: 186. PMID: 37193687, PMCID: PMC10188524, DOI: 10.1038/s41392-023-01404-9.Peer-Reviewed Original ResearchConceptsSomatostatin-positive interneuronsCortical dysplasiaSeizure networkDentate gyrusParvalbumin-positive interneuronsSomatostatin-positive neuronsExcitatory transmissionDysplastic lesionsSomatostatin interneuronsPoor prognosisSomatostatin-positiveEpileptic hippocampusImmunohistochemical studiesCalcium imagingDysplasiaInterneuronsElectrophysiological recordingsSeizure generalizationCellular basisSeizuresInhibitory roleHippocampusOptogenetic studiesDentateCellular substrates
2017
Immunohistochemical Characterization of the Origins of Metastatic Well-differentiated Neuroendocrine Tumors to the Liver
Yang Z, Klimstra D, Hruban R, Tang L. Immunohistochemical Characterization of the Origins of Metastatic Well-differentiated Neuroendocrine Tumors to the Liver. The American Journal Of Surgical Pathology 2017, 41: 915-922. PMID: 28498280, DOI: 10.1097/pas.0000000000000876.Peer-Reviewed Original ResearchConceptsMetastatic neuroendocrine tumorsWell-differentiated neuroendocrine tumorsMetastatic well-differentiated neuroendocrine tumorNeuroendocrine tumorsPrimary sitePrimary tumorPatient managementPredictive valueExpression of TTF1Potential primary sitesPancreatic neuroendocrine tumorsNegative predictive valuePositive predictive valueSmall intestineStatistically significant associationSite of originMetastatic adenocarcinomaPathology reviewTumor gradeMetastatic neoplasmsLung carcinoidsPathology archivesTissue microarrayStudy cohortImmunohistochemical studies
1996
Subclassification of Gastrointestinal Stromal Tumors Based on Evaluation by Electron Microscopy and Immunohistochemistry
Erlandson R, Klimstra D, Woodruff J. Subclassification of Gastrointestinal Stromal Tumors Based on Evaluation by Electron Microscopy and Immunohistochemistry. Ultrastructural Pathology 1996, 20: 373-393. PMID: 8837346, DOI: 10.3109/01913129609016340.Peer-Reviewed Original ResearchConceptsGastrointestinal autonomic nerve tumorsGastrointestinal stromal tumorsSmooth muscle tumorsMuscle tumorsStromal tumorsNeuron specific enolase positive cellsSmall intestineNerve tumorsSynapse-like structuresLeiomyosarcoma casesImmunophenotypic analysisCD34+HHF-35Smooth muscleTumor cellsPositive cellsImmunohistochemical studiesTumorSensitive markerUltrastructural examinationLeiomyosarcomaUltrastructural demonstrationNeurosecretory granulesCD34Immunophenotype
1992
Cerebral Hemorrhage With Biopsy-Proved Amyloid Angiopathy
Yong W, Robert M, Secor D, Kleikamp T, Vinters H. Cerebral Hemorrhage With Biopsy-Proved Amyloid Angiopathy. JAMA Neurology 1992, 49: 51-58. PMID: 1728264, DOI: 10.1001/archneur.1992.00530250055016.Peer-Reviewed Original ResearchConceptsBiopsy specimensAcute clinical presentationComputed tomographic scanFocal neurological deficitsBrain biopsy specimensTransient ischemic attackBiopsy-provedClinical presentationRing enhancementLoss of consciousnessRadiological featuresImpending hemorrhageTomographic scanIntracerebral hemorrhageLobar hemorrhageNeurological deficitsBiopsy materialImmunohistochemical findingsImmunohistochemical studiesIntraparenchymal bleedingHemorrhageCerebral hemorrhageIschemic attackBrain hemorrhagePatients
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