2024
Comparison of combined intravenous and intra-arterial thrombolysis with intravenous thrombolysis alone in stroke patients undergoing mechanical thrombectomy: a propensity-matched analysis
Elawady S, Kasem R, Mulpur B, Cunningham C, Matsukawa H, Sowlat M, Orscelik A, Nawabi N, Isidor J, Maier I, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Samaniego E, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Grandhi R, Crosa R, Matouk C, Park M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Altschul D, Spiotta A, Levitt M, Goyal N. Comparison of combined intravenous and intra-arterial thrombolysis with intravenous thrombolysis alone in stroke patients undergoing mechanical thrombectomy: a propensity-matched analysis. Journal Of NeuroInterventional Surgery 2024, 17: e261-e268. PMID: 39179373, DOI: 10.1136/jnis-2024-021975.Peer-Reviewed Original ResearchSymptomatic intracranial hemorrhageAIS-LVO patientsIntracranial hemorrhageIntra-arteriallyModified Rankin ScaleNeurological improvementMechanical thrombectomyIAT groupFunctional outcomesIntra-arterial groupModified Rankin scale 0Long-term functional outcomeRate of recanalizationPropensity-matched analysisIntra-arterial thrombolysisLarge vessel occlusionStroke patientsAcute ischemic strokeSecondary outcomesPrimary outcomePropensity score matchingNo significant differencePropensity matchingAIS-LVOMT+IVT groupClinical and radiographic outcomes after mechanical thrombectomy in medium-vessel posterior cerebral artery occlusions: Subgroup analysis from STAR.
Almallouhi E, Findlay M, Maier I, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Shaban A, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Crosa R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Altschul D, Spiotta A, Grandhi R. Clinical and radiographic outcomes after mechanical thrombectomy in medium-vessel posterior cerebral artery occlusions: Subgroup analysis from STAR. Interventional Neuroradiology 2024, 15910199241273839. PMID: 39140967, PMCID: PMC11569802, DOI: 10.1177/15910199241273839.Peer-Reviewed Original ResearchPosterior cerebral arteryMiddle cerebral arteryMedium vessel occlusionsFirst-pass recanalizationMechanical thrombectomyCerebral arteryPosterior cerebral artery occlusionStandard-of-care treatmentPatients' median ageFirst-pass success rateIntra-arterial thrombolysisLarge-vessel occlusionCerebral artery occlusionSalvageable brain tissuePrimary occlusionMedian ageClinical outcomesRadiographic outcomesRecanalization rateFollow-upSubgroup analysisArtery occlusionRecanalizationStroke thrombectomyPatients
2023
Successful percutaneous management of hypothenar hammer syndrome with thrombosuction and catheter-directed intra-arterial thrombolysis
Aggarwal A, Markiel J, Chandra N, Buller G, Smolderen K, Mena-Hurtado C. Successful percutaneous management of hypothenar hammer syndrome with thrombosuction and catheter-directed intra-arterial thrombolysis. Journal Of Vascular Surgery Cases And Innovative Techniques 2023, 10: 101384. PMID: 38205441, PMCID: PMC10777006, DOI: 10.1016/j.jvscit.2023.101384.Peer-Reviewed Original ResearchHypothenar hammer syndromeIntra-arterial thrombolysisLimb ischemiaPercutaneous managementCatheter-directed intra-arterial thrombolysisAcute digital ischemiaAcute limb ischemiaChronic limb ischemiaSuccessful percutaneous managementUlnar artery thrombosisRare vascular disorderBrachial artery accessTraditional surgical approachesAnticoagulation therapyArtery thrombosisDigital ischemiaSymptomatic reliefArtery accessSurgical interventionSurgical approachConservative measuresVascular disordersBlood flowInvasive techniquesDefinitive consensus
2017
Ischemic Stroke Profile, Risk Factors, and Outcomes in India
Sylaja P, Pandian J, Kaul S, Srivastava M, Khurana D, Schwamm L, Kesav P, Arora D, Pannu A, Thankachan T, Singhal A. Ischemic Stroke Profile, Risk Factors, and Outcomes in India. Stroke 2017, 49: 219-222. PMID: 29167386, PMCID: PMC5742046, DOI: 10.1161/strokeaha.117.018700.Peer-Reviewed Original ResearchConceptsAdmission National InstitutesHealth Stroke ScaleStroke ScaleIschemic strokeDiabetes mellitusRisk factorsHealth Stroke Scale scoreLower admission National InstitutesMedian admission National InstitutesNational InstituteRankin Scale score 0Stroke etiologic subtypesIntra-arterial thrombolysisStroke Scale scoreAcademic tertiary hospitalCommon risk factorsMagnetic resonance imagingHospital mortalityEtiologic subtypesStroke careStroke ProjectTertiary hospitalAtrial fibrillationStroke guidelinesMean age
2011
CT angiography predicts use of tertiary interventional services in acute ischemic stroke patients
Thomas L, Goldstein J, Hakimelahi R, Chang Y, Yoo A, Schwamm L, Gonzalez R. CT angiography predicts use of tertiary interventional services in acute ischemic stroke patients. International Journal Of Emergency Medicine 2011, 4: 62. PMID: 21967677, PMCID: PMC3203028, DOI: 10.1186/1865-1380-4-62.Peer-Reviewed Original ResearchCerebral artery occlusionProximal cerebral artery occlusionEmergent CT angiographyIschemic stroke patientsCT angiographyProximal occlusionArtery occlusionNegative predictive valuePositive predictive valueIndependent predictorsStroke patientsNeurointerventional servicesInitial NIH Stroke Scale scorePredictive valueConsecutive ischemic stroke patientsAcute ischemic stroke patientsNIH Stroke Scale scoreInterventional servicesMechanical clot retrievalTertiary care interventionsIntra-arterial thrombolysisStroke Scale scoreAcute ischemic strokeTertiary care centerHistorical cohort study
2010
Management of Thrombolysis-Associated Symptomatic Intracerebral Hemorrhage
Goldstein J, Marrero M, Masrur S, Pervez M, Barrocas A, Abdullah A, Oleinik A, Rosand J, Smith E, Dzik W, Schwamm L. Management of Thrombolysis-Associated Symptomatic Intracerebral Hemorrhage. JAMA Neurology 2010, 67: 965-969. PMID: 20697046, PMCID: PMC3690951, DOI: 10.1001/archneurol.2010.175.Peer-Reviewed Original ResearchConceptsSymptomatic intracerebral hemorrhageIntra-arterial thrombolysisHospital mortalityIntracerebral hemorrhageHealth Stroke Scale scoreIntravenous tissue plasminogen activatorGuidelines-Stroke databaseStroke Scale scoreAcute ischemic strokeMultivariable logistic regressionFresh frozen plasmaTissue plasminogen activatorMulticenter registryAcute strokeDevastating complicationIschemic strokeIndependent predictorsThrombolytic therapyFrozen plasmaAppropriate treatmentRetrospective analysisPatientsScale scoreCoagulopathyThrombolysis
2008
CT Angiography-Source Image Hypoattenuation Predicts Clinical Outcome in Posterior Circulation Strokes Treated With Intra-Arterial Therapy
Schaefer P, Yoo A, Bell D, Barak E, Romero J, Nogueira R, Lev M, Schwamm L, Gonzalez R, Hirsch J. CT Angiography-Source Image Hypoattenuation Predicts Clinical Outcome in Posterior Circulation Strokes Treated With Intra-Arterial Therapy. Stroke 2008, 39: 3107-3109. PMID: 18703807, DOI: 10.1161/strokeaha.108.517680.Peer-Reviewed Original ResearchConceptsIntra-arterial thrombolysisVertebrobasilar occlusionClinical outcomesParenchymal hypoattenuationRankin scorePosterior circulation strokeHealth Stroke ScaleIntra-arterial therapyOnly independent predictorIndependent outcome predictorsMedial temporal lobeInferior parietal lobeStroke ScaleClot locationPatient ageCTA-SIIndependent predictorsOutcome predictorsOccipital lobeHypoattenuationTemporal lobeThrombolysisParietal lobePatientsMidbrainAdvance Hospital Notification by EMS in Acute Stroke Is Associated with Shorter Door-to-Computed Tomography Time andIncreased Likelihood of Administration of Tissue-Plasminogen Activator
Abdullah A, Smith E, Biddinger P, Kalenderian D, Schwamm L. Advance Hospital Notification by EMS in Acute Stroke Is Associated with Shorter Door-to-Computed Tomography Time andIncreased Likelihood of Administration of Tissue-Plasminogen Activator. Prehospital Emergency Care 2008, 12: 426-431. PMID: 18924004, DOI: 10.1080/10903120802290828.Peer-Reviewed Original ResearchConceptsEmergency medical servicesTissue plasminogen activatorAcute stroke patientsStroke patientsTertiary care stroke centerIntravenous tissue plasminogen activatorCatheter-based thrombolysisED arrival timeHospital time intervalsIntra-arterial thrombolysisMedian National InstitutesHealth Stroke ScaleUse of thrombolysisEmergency department arrivalTerms of ageHigher baseline ratesPrior strokeTPA useAcute strokeStroke centersStroke ScaleSymptom onsetStroke databaseMild strokeHospital notification
2005
Arterial thrombosis associated with heterozygous factor V Leiden disorder, hyperhomocysteinemia, and peripheral arterial disease: Importance of synergistic factors
Page C, Rubin LE, Gusberg RJ, Dardik A. Arterial thrombosis associated with heterozygous factor V Leiden disorder, hyperhomocysteinemia, and peripheral arterial disease: Importance of synergistic factors. Journal Of Vascular Surgery 2005, 42: 1014-1018. PMID: 16275464, DOI: 10.1016/j.jvs.2005.06.019.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAcute DiseaseAngiographyFactor VFactor V DeficiencyFibrinolytic AgentsFollow-Up StudiesHeparinHeterozygoteHumansHyperhomocysteinemiaInjections, Intra-ArterialMaleMiddle AgedMutationPeripheral Vascular DiseasesPopliteal ArteryThromboembolismThrombolytic TherapyTissue Plasminogen ActivatorConceptsPeripheral arterial diseaseArterial diseaseArterial thrombosisPre-existing peripheral arterial diseaseAcute popliteal artery thrombosisAcute arterial thrombosisPopliteal artery thrombosisIntra-arterial thrombolysisRisk factor modificationDeep venous thrombosisLong-term treatmentFactor V LeidenArtery thrombosisAcute thrombosisVenous thrombosisHomocysteine levelsFactor modificationV LeidenNormal limitsThrombosisHyperhomocysteinemiaFolic acidDiseaseDisordersAnticoagulation
2004
768 First-pass Quantitative Computed Tomographic Perfusion Identifies Salvageable Penumbra in Acute Stroke Patients Treated with Intra-arterial Thrombolysis
Hoh B, Roccatagliata L, Lev M, Ledezma C, Schwamm L, Koroshetz W, Schaefer P. 768 First-pass Quantitative Computed Tomographic Perfusion Identifies Salvageable Penumbra in Acute Stroke Patients Treated with Intra-arterial Thrombolysis. Neurosurgery 2004, 55: 475. DOI: 10.1097/00006123-200408000-00104.Peer-Reviewed Original ResearchIntra-arterial thrombolysisAcute stroke patientsSalvageable penumbraStroke patientsThrombolysisPatients768 First-pass Quantitative Computed Tomographic Perfusion Identifies Salvageable Penumbra in Acute Stroke Patients Treated with Intra-arterial Thrombolysis
Hoh B, Roccatagliata L, Lev M, Ledezma C, Schwamm L, Koroshetz W, Schaefer P. 768 First-pass Quantitative Computed Tomographic Perfusion Identifies Salvageable Penumbra in Acute Stroke Patients Treated with Intra-arterial Thrombolysis. Neurosurgery 2004, 55: 475-475. DOI: 10.1227/00006123-200408000-00104.Peer-Reviewed Original ResearchIntra-arterial thrombolysisAcute stroke patientsSalvageable penumbraStroke patientsThrombolysisPatientsCharacterization and evolution of diffusion MR imaging abnormalities in stroke patients undergoing intra-arterial thrombolysis.
Schaefer P, Hassankhani A, Putman C, Sorensen A, Schwamm L, Koroshetz W, Gonzalez R. Characterization and evolution of diffusion MR imaging abnormalities in stroke patients undergoing intra-arterial thrombolysis. American Journal Of Neuroradiology 2004, 25: 951-7. PMID: 15205129, PMCID: PMC7975652.Peer-Reviewed Original ResearchConceptsIntra-arterial thrombolysisDiffusion-weighted imagingDWI findingsDWI ratioADC ratioReperfusion therapyAcute strokeApparent diffusion coefficientInitial diffusion-weighted imagingPretreatment diffusion-weighted imagingADC valuesRespective mean changesEventual infarctionAcute occlusionAnterior circulationStroke patientsLesion volumeMean changePatientsThrombolysisLesion growthMR imagingTissue viabilityLesionsInfarction
2001
Utility of Perfusion-Weighted CT Imaging in Acute Middle Cerebral Artery Stroke Treated With Intra-Arterial Thrombolysis:
Lev M, Segal A, Farkas J, Hossain S, Putman C, Hunter G, Budzik R, Harris G, Buonanno F, Ezzeddine M, Chang Y, Koroshetz W, Gonzalez R, Schwamm L. Utility of Perfusion-Weighted CT Imaging in Acute Middle Cerebral Artery Stroke Treated With Intra-Arterial Thrombolysis:. Stroke 2001, 32: 2021-2028. PMID: 11546891, DOI: 10.1161/hs0901.095680.Peer-Reviewed Original ResearchConceptsFinal infarct volumeAcute middle cerebral artery strokeNIH Stroke Scale scoreMiddle cerebral artery strokeMCA stem occlusionIntra-arterial thrombolysisStroke Scale scoreComplete recanalizationClinical outcomesInfarct volumeLesion volumeArtery strokeOutcome groupAdmission NIH Stroke Scale scoreInitial NIH Stroke Scale scoreScale scoreEarly complete recanalizationFinal lesion volumeUtility of perfusionPoor outcome groupModified Rankin ScalePoor clinical outcomeRankin ScaleStroke onsetConsecutive patients
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