2024
Postdural puncture headache: Beyond the evidence
Berg A, Lucas D, Leffert L. Postdural puncture headache: Beyond the evidence. Best Practice & Research Clinical Anaesthesiology 2024, 38: 267-277. PMID: 39764816, DOI: 10.1016/j.bpa.2024.11.004.Peer-Reviewed Original ResearchPostdural puncture headacheCalcitonin gene-related peptideAccidental dural punctureCerebrospinal fluidRelease of calcitonin gene-related peptideManagement of postdural puncture headacheTreat postdural puncture headacheLabor epidural analgesiaGene-related peptideAutonomic nervous systemCerebrospinal fluid dynamicsEvidence-based recommendationsEpidural analgesiaPuncture headacheDural punctureIntrathecal catheterNeuraxial proceduresCSF lossSphenopalatine ganglionAssociated with activationCerebral arteryCerebral vasodilationChronic manifestationsTherapeutic strategiesRoutine use
2023
Trajectory of blood pressure after initiating anti-calcitonin gene-related peptide treatment of migraine: a target trial emulation from the veterans health administration
Wang K, Fenton B, Dao V, Guirguis A, Anthony S, Skanderson M, Sico J. Trajectory of blood pressure after initiating anti-calcitonin gene-related peptide treatment of migraine: a target trial emulation from the veterans health administration. The Journal Of Headache And Pain 2023, 24: 108. PMID: 37582724, PMCID: PMC10426172, DOI: 10.1186/s10194-023-01640-y.Peer-Reviewed Original ResearchConceptsAnti-CGRP treatmentVeterans Health AdministrationBlood pressureBP changesHealth AdministrationDiastolic BP changesExacerbation of hypertensionNumber of antihypertensivesIncidence of hypertensionHigher healthcare utilizationSystolic BP changeKaplan-Meier curvesBlood pressure readingsGene-related peptideTarget trial emulationYears of treatmentBlood pressure regulationHigh-quality real-world evidenceReal-world evidenceMixed-effects Poisson modelsChronic migraine diagnosisInverse probability weightsAntihypertension medicationsAntihypertensive medicationsBaseline hypertensionCalcitonin Gene–Related Peptide Monoclonal Antibodies and Risk of SARS-CoV-2 Infection and Severe COVID-19 Outcomes Among Veterans With Migraine Disorder
Wang K, Fenton B, Deng Y, Anthony S, Dao V, Schindler E, Lipton R, Guirguis A, Skanderson M, Seng E, Sico J. Calcitonin Gene–Related Peptide Monoclonal Antibodies and Risk of SARS-CoV-2 Infection and Severe COVID-19 Outcomes Among Veterans With Migraine Disorder. JAMA Network Open 2023, 6: e2326371. PMID: 37523183, PMCID: PMC10391301, DOI: 10.1001/jamanetworkopen.2023.26371.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptideSARS-CoV-2 infectionSevere COVID-19 outcomesCGRP mAbsMechanical ventilationSupplemental oxygenCOVID-19 outcomesSARS-CoV-2Cohort studyCGRP antagonistMAIN OUTCOMEMigraine disordersPositive SARS-CoV-2 test resultSARS-CoV-2 test resultsCOVID-19Protocol hazard ratiosRetrospective cohort studyMonoclonal antibody treatmentGene-related peptideLikelihood of hospitalizationCourse of diseasePeptide monoclonal antibodyElectronic health recordsNeuroimmune modulatorCumulative incidence
2022
CGRP, Migraine, and Brain MRI in CADASIL
Goldstein E, Gopal N, Badi M, Hodge D, de Havenon A, Glover P, Durham P, Huang J, Lin M, Baradaran H, Majersik J, Meschia J. CGRP, Migraine, and Brain MRI in CADASIL. The Neurologist 2022, 28: 231-236. PMID: 36729391, PMCID: PMC10277309, DOI: 10.1097/nrl.0000000000000478.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptideMigraine-related disabilitySerum calcitonin gene-related peptideSerum CGRP levelsCGRP levelsBrain magnetic resonance imagingCerebral autosomal dominant arteriopathyGene-related peptideAutosomal dominant arteriopathyMagnetic resonance imagingCross-sectional analysisRadiographic associationRadiographic implicationsPrimary outcomeT2 hyperintensityCerebral microbleedsDisability ScaleSubcortical infarctsMigraine pathophysiologyVasoactive peptidesBrain MRIMigraine pathologyMigraineResonance imagingCADASILSerum Calcitonin Gene-Related Peptide Is Elevated in Patients With Migraine and Ophthalmoplegia
Takkar A, Kumar K, Katoch D, Singh P, Minz R, Anand S, Kathirvel S, Ravishankar K, Lal V, Caplan L. Serum Calcitonin Gene-Related Peptide Is Elevated in Patients With Migraine and Ophthalmoplegia. Journal Of Neuro-Ophthalmology 2022, 43: 399-405. PMID: 36255114, DOI: 10.1097/wno.0000000000001695.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptideSerum CGRP levelsSerum calcitonin gene-related peptideCalcitonin gene-related peptide levelsCGRP levelsIctal phaseElevated serum CGRP levelsHeadaches consistent with migraineConsistent with migraineICHD-3 criteriaGene-related peptideSex-matched controlsSerum of patientsCase-control studyInflammatory neuropathiesICHD-3Episodic headacheInterictal phaseOphthalmoplegiaMigraineAge-matchedPatientsSerumHeadacheAbducens
2020
Eptinezumab Demonstrated Efficacy in Sustained Prevention of Episodic and Chronic Migraine Beginning on Day 1 After Dosing
Dodick DW, Gottschalk C, Cady R, Hirman J, Smith J, Snapinn S. Eptinezumab Demonstrated Efficacy in Sustained Prevention of Episodic and Chronic Migraine Beginning on Day 1 After Dosing. Headache The Journal Of Head And Face Pain 2020, 60: 2220-2231. PMID: 33165938, PMCID: PMC7756794, DOI: 10.1111/head.14007.Peer-Reviewed Original ResearchConceptsEptinezumab 100Days/monthDay 1Chronic migrainePreventive efficacyCalcitonin gene-related peptideMonthly migraine daysPercentage of patientsPrevention of migraineGene-related peptideTreatment effectsMigraine preventive effectMigraine daysInitial dosePreventive effectEptinezumabWeek 1MigrainePatientsPlaceboSustained preventionMonoclonal antibodiesEfficacyMonthsNonsignificant results
2016
Nucleotide homeostasis and purinergic nociceptive signaling in rat meninges in migraine-like conditions
Yegutkin G, Guerrero-Toro C, Kilinc E, Koroleva K, Ishchenko Y, Abushik P, Giniatullina R, Fayuk D, Giniatullin R. Nucleotide homeostasis and purinergic nociceptive signaling in rat meninges in migraine-like conditions. Purinergic Signalling 2016, 12: 561-574. PMID: 27369815, PMCID: PMC5023636, DOI: 10.1007/s11302-016-9521-8.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine DiphosphateAdenosine MonophosphateAdenosine TriphosphateAnimalsCalcitonin Gene-Related PeptideCell SeparationDisease Models, AnimalHomeostasisImmunohistochemistryMaleMeningesMigraine DisordersNucleotidesPatch-Clamp TechniquesRatsRats, WistarReceptors, PurinergicTrigeminal GanglionConceptsCalcitonin gene-related peptideMigraine painTrigeminal cellsRat meningesAdenosine concentrationExtracellular ATPMedial meningeal arteryPro-nociceptive effectsGene-related peptideTrigeminal nerve fibersLarge intracellular Ca2Meningeal nervesTrigeminal painPurinergic mechanismsTrigeminal nervePurinergic hypothesisP2X7 receptorGlial cellsMigraine headacheNerve fibersMeningeal arteryIntracellular Ca2MeningesPainExtracellular AMP
2014
Calcitonin Gene-Related Peptide Neurons Mediate Sleep-Specific Circadian Output in Drosophila
Kunst M, Hughes ME, Raccuglia D, Felix M, Li M, Barnett G, Duah J, Nitabach MN. Calcitonin Gene-Related Peptide Neurons Mediate Sleep-Specific Circadian Output in Drosophila. Current Biology 2014, 24: 2652-2664. PMID: 25455031, PMCID: PMC4255360, DOI: 10.1016/j.cub.2014.09.077.Peer-Reviewed Original ResearchConceptsPigment-dispersing factorNeuropeptide calcitonin gene-related peptideCalcitonin gene-related peptideGene-related peptidePDF receptorClock neuronsCircadian clock neuronsDistinct neuronal pathwaysNeuropeptide pigment-dispersing factorDorsal clock neuronsAmount of sleepHomeostatic sleep driveNeurons actsCalcitonin geneNeuronal pathwaysTiming of sleepSleepMental healthSleep driveReceptorsNovel roleCircadian rhythmDH31NeuronsLocomotor rhythmMechanisms involved in attenuated cardio-protective role of ischemic preconditioning in metabolic disorders
Rana A, Goyal N, Ahlawat A, Jamwal S, Reddy B, Sharma S. Mechanisms involved in attenuated cardio-protective role of ischemic preconditioning in metabolic disorders. Perfusion 2014, 30: 94-105. PMID: 24947460, DOI: 10.1177/0267659114536760.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptideIschemic preconditioningDiabetes mellitusMito-KATP channelMitochondrial permeability transition poreChronic diabetes mellitusGene-related peptideCardio-protective roleIschemia/reperfusionSub-lethal ischemiaGlycogen synthase kinase-3βSynthase kinase-3βCardioprotective effectsMyocardial damageMyocardial infarctionBlood supplyPart of heartMetabolic disordersInvolvement of PTENBeneficial effectsPTEN inhibitorKinase-3βPathological statesMellitusHyperlipidemia
1998
Peptidergic innervation and the nicotinic acetylcholine receptor in the primate basal nucleus
Csillik B, Rakic P, Knyihár‐Csillik E. Peptidergic innervation and the nicotinic acetylcholine receptor in the primate basal nucleus. European Journal Of Neuroscience 1998, 10: 573-585. PMID: 9749720, DOI: 10.1046/j.1460-9568.1998.00066.x.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptidePrincipal nerve cellsNeuropeptide YNicotinic acetylcholine receptorsSubstance PBasal nucleusAcetylcholine receptorsPeptidergic innervationBasal forebrainPrincipal cellsElectron microscopic pre-embedding immunocytochemistryAlpha-BTXNerve cellsNeuronal nicotinic acetylcholine receptorsMeynert's basal nucleusCholine acetyltransferase immunoreactivityGene-related peptideImmunohistochemical double stainingPre-embedding immunocytochemistryImmunopositive axonsPresynaptic nAChRsCGRP immunoreactivityAcetylcholine releaseNeuronal nAChRsGlomerular arrangement
1995
Histometric effects of ciliary neurotrophic factor in wobbler mouse motor neuron disease
Ikeda K, Wong V, Holmlund T, Greene T, Cedarbaum J, Lindsay R, Mitsumoto H. Histometric effects of ciliary neurotrophic factor in wobbler mouse motor neuron disease. Annals Of Neurology 1995, 37: 47-54. PMID: 7818257, DOI: 10.1002/ana.410370110.Peer-Reviewed Original ResearchConceptsCiliary neurotrophic factorMotor neuron diseaseNeurotrophic factorMotor neuronsHuman ciliary neurotrophic factorNeuron diseaseWobbler miceWobbler mouse motor neuron diseaseMouse motor neuron diseaseCalcitonin gene-related peptideAcute axonal degenerationAxonal branching pointsBiceps muscle weightC5 ventral rootsGene-related peptidePercentage of axonsAtrophied muscle fibersUntreated control groupRat ciliary neurotrophic factorMean muscle fiber diameterMusculocutaneous nerveAxonal degenerationVentral rootsSubcutaneous injectionVacuolar degeneration
1993
Distribution of calcitonin gene-related peptide in vertebrate neuromuscular junctions: relationship to the acetylcholine receptor.
Csillik B, Tajti L, Kovács T, Kukla E, Rakic P, Knyihár-Csillik E. Distribution of calcitonin gene-related peptide in vertebrate neuromuscular junctions: relationship to the acetylcholine receptor. Journal Of Histochemistry & Cytochemistry 1993, 41: 1547-1555. PMID: 8245413, DOI: 10.1177/41.10.8245413.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptideGene-related peptideCGRP immunoreactivityMotor endplatesMotor axonsNeuromuscular junctionAcetylcholine receptorsWallerian degenerationAccumulation of CGRPTonic musclesPresence of CGRPNeuromuscular transmission resultsRat muscleMotor nerve endingsChloral hydrate anesthesiaPresynaptic axon terminalsMotor nervesBupivacaine injectionNerve endingsSupramaximal stimulationAxon terminalsAxon regenerationVertebrate neuromuscular junctionTetanic muscleBuccinator muscleCalcitonin gene-related peptide mediates hypotension and tachycardia in endotoxic rats
Huttemeier P, Ritter E, Benveniste H. Calcitonin gene-related peptide mediates hypotension and tachycardia in endotoxic rats. American Journal Of Physiology 1993, 265: h767-h769. PMID: 8368378, DOI: 10.1152/ajpheart.1993.265.2.h767.Peer-Reviewed Original ResearchConceptsAcute circulatory changesCirculatory changesSurvival rateCalcitonin gene-related peptide concentrationsCalcitonin gene-related peptideMean blood pressureOverall survival rateGene-related peptideRegional blood flowEscherichia coli endotoxinClinical sepsisSevere hypotensionBlood pressureEndotoxic ratsCardiac functionCGRP antagonismColi endotoxinBlood flowUntreated animalsHypotensionTachycardiaSepsisRatsCGRPHCGRP
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