2017
Cholinergic activity and levodopa‐induced dyskinesia: a multitracer molecular imaging study
Brumberg J, Küsters S, Al‐Momani E, Marotta G, Cosgrove KP, van Dyck C, Herrmann K, Homola GA, Pezzoli G, Buck AK, Volkmann J, Samnick S, Isaias IU. Cholinergic activity and levodopa‐induced dyskinesia: a multitracer molecular imaging study. Annals Of Clinical And Translational Neurology 2017, 4: 632-639. PMID: 28904985, PMCID: PMC5590520, DOI: 10.1002/acn3.438.Peer-Reviewed Original ResearchLevodopa-induced dyskinesiaNicotinic acetylcholine receptorsSingle photon emissionNondyskinetic patientsDisease patientsCholinergic activityHealthy controlsAcetylcholine receptorsRegional cerebral metabolic activityDeoxyglucose positron emission tomographyExpression of dyskinesiaCerebral metabolic activityStriatal cholinergic activityParkinson's disease patientsBasal ganglia structuresStriatal binding potentialPositron emission tomographyDopaminergic responsivenessAffected sideClinical variablesDyskinetic subjectsCholinergic signalingGanglia structuresMolecular imaging studiesNeuronal excitability
2015
Dynamic Cerebral Autoregulation Is Transiently Impaired for One Week after Large-Vessel Acute Ischemic Stroke
Petersen NH, Ortega-Gutierrez S, Reccius A, Masurkar A, Huang A, Marshall RS. Dynamic Cerebral Autoregulation Is Transiently Impaired for One Week after Large-Vessel Acute Ischemic Stroke. Cerebrovascular Diseases 2015, 39: 144-150. PMID: 25661277, PMCID: PMC4754197, DOI: 10.1159/000368595.Peer-Reviewed Original ResearchConceptsDynamic cerebral autoregulationLarge-vessel ischemic strokeUnaffected hemisphereAffected hemisphereIschemic strokeCerebral autoregulationBlood pressureAcute large-vessel ischemic strokeLarge vessel acute ischemic strokeAcute blood pressure managementMiddle cerebral artery territoryAcute ischemic strokeBlood pressure managementCerebral blood flowBlood flow velocityDay strokePoor autoregulationAcute strokeArtery territoryArterial catheterTranscranial DopplerAffected sideUnaffected sideControl subjectsHealthy controls
2013
Acute, Unilateral Transient Blepharoptosis of Unknown Etiology
Arat Y, Yazici B, Hekimhan-Kaynak P, Chaudhry I, Wladis E. Acute, Unilateral Transient Blepharoptosis of Unknown Etiology. Ophthalmic Plastic And Reconstructive Surgery 2013, 29: 396-399. PMID: 24022352, DOI: 10.1097/iop.0b013e31829d02c7.Peer-Reviewed Original ResearchConceptsUnilateral blepharoptosisLevator functionRare conditionUnknown etiologyHistory of flu-like illnessDecreased levator functionFlu-like syndromeFollow-up periodFlu-like illnessAcute ptosisTotal ptosisPupil abnormalitiesBlepharoptosisPtosisPatientsMedical recordsAffected sideEtiologyLimited motilityLevatorWorkupSyndromeAbnormalitiesClinicHistory
2011
Adenosine A2A Receptors Measured with [11C]TMSX PET in the Striata of Parkinson's Disease Patients
Mishina M, Ishiwata K, Naganawa M, Kimura Y, Kitamura S, Suzuki M, Hashimoto M, Ishibashi K, Oda K, Sakata M, Hamamoto M, Kobayashi S, Katayama Y, Ishii K. Adenosine A2A Receptors Measured with [11C]TMSX PET in the Striata of Parkinson's Disease Patients. PLOS ONE 2011, 6: e17338. PMID: 21386999, PMCID: PMC3046146, DOI: 10.1371/journal.pone.0017338.Peer-Reviewed Original ResearchConceptsDrug-naïve patientsDrug-naïve PD patientsPositron emission tomographyPD patientsParkinson's diseaseAntiparkinsonian therapyControl subjectsAffected sideDisease patientsCaudate nucleusParkinson's disease patientsElderly control subjectsNormal control subjectsSelective A2AR antagonistAdenosine A2A receptorsDistribution volume ratioMild dyskinesiaA2AR antagonistDopaminergic systemBilateral putamenPET scansPatientsA2A receptorsNovel treatmentsPutamen
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