2023
MicroRNA-mediated translational pathways are regulated in the orbitofrontal cortex and peripheral blood samples during acute abstinence from heroin self-administration
Zanda M, Saikali L, Morris P, Daws S. MicroRNA-mediated translational pathways are regulated in the orbitofrontal cortex and peripheral blood samples during acute abstinence from heroin self-administration. Advances In Drug And Alcohol Research 2023, 3: 11668. PMID: 38389822, PMCID: PMC10880771, DOI: 10.3389/adar.2023.11668.Peer-Reviewed Original ResearchHeroin self-administrationOrbitofrontal cortexSelf-AdministrationDays of forced abstinenceRegulating drug-seeking behaviorSucrose self-administrationDrug-seeking behaviorChronic drug exposureAdult male ratsPeripheral blood samplesHeroin infusionsHeroin seekingMolecular neuroadaptationsForced abstinenceAcute abstinenceNeurobiological consequencesOpioid heroinOpioid misuseHeroinMale ratsSelf-AdministeredSeeking behaviorAbstinenceBlood samplesOpioid exposure
2022
Sex- and estrous-cycle dependent dorsal hippocampal phosphoproteomic changes induced by low-dose ketamine
Saland SK, Wilczak K, Voss E, Lam TT, Kabbaj M. Sex- and estrous-cycle dependent dorsal hippocampal phosphoproteomic changes induced by low-dose ketamine. Scientific Reports 2022, 12: 1820. PMID: 35110693, PMCID: PMC8810966, DOI: 10.1038/s41598-022-05937-x.Peer-Reviewed Original ResearchConceptsLow-dose ketamineFemale ratsMale ratsTherapeutic effectIntact adult male ratsNMDA receptor antagonist ketamineAcute low doseKetamine's therapeutic effectsRapid antidepressant actionsAdult male ratsKetamine-induced changesRapid actionAntidepressant actionAntidepressant ketamineHormonal milieuHormone-dependent modulationHormonal statusLow doseKetamineBrain regionsRatsSynaptic signalingPathway activationBi-directional effectsCritical modulator
2020
Dysregulation of Decision Making Related to Metabotropic Glutamate 5, but Not Midbrain D3, Receptor Availability Following Cocaine Self-administration in Rats
Groman SM, Hillmer AT, Liu H, Fowles K, Holden D, Morris ED, Lee D, Taylor JR. Dysregulation of Decision Making Related to Metabotropic Glutamate 5, but Not Midbrain D3, Receptor Availability Following Cocaine Self-administration in Rats. Biological Psychiatry 2020, 88: 777-787. PMID: 32826065, PMCID: PMC8935943, DOI: 10.1016/j.biopsych.2020.06.020.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsProbabilistic reversalRelapse-like behaviorTest of motivationReceptor availabilityPersistent drug useMetabotropic glutamate 5Neural mechanismsCompulsive patternsDecision-making processDrug-induced adaptationsSelective impairmentDrug useWeeks of abstinenceCocaine takingCocaine Self-AdministrationBrain regionsDegree of disruptionDays of cocaineAdult male ratsCocaine-induced increasesCocaine-induced changesDrug-induced alterationsRobust alterationsPositron emission tomography
2019
High-intensity interval training has a greater effect on reverse cholesterol transport elements compared with moderate-intensity continuous training in obese male rats
Rahmati-Ahmadabad S, Azarbayjani M, Farzanegi P, Moradi L. High-intensity interval training has a greater effect on reverse cholesterol transport elements compared with moderate-intensity continuous training in obese male rats. European Journal Of Preventive Cardiology 2019, 28: 692-701. PMID: 33611472, DOI: 10.1177/2047487319887828.Peer-Reviewed Original ResearchReverse cholesterol transportHigh-fat dietModerate-intensity continuous trainingHigh-intensity interval trainingMale ratsHFD-HIITHigh-density lipoprotein cholesterolPlasma high-density lipoprotein cholesterolObese male ratsAdult male ratsReverse cholesterol transport processInterval trainingObese subjectsEffects of high-intensity interval trainingPearson correlation testContinuous trainingLipoprotein cholesterolPPARG gene expressionPlasma apo A1Apo-A1Cardioprotective effectsHFD controlRatsCholesterol transportPPARG expressionAbstract WP150: Autophagy Regulates NLRP3 Inflammasome in Cerebral Ischemia With Comorbid Stress: A Protective Mechanism of Progesterone
Espinosa-Garcia C, Atif F, Yousuf S, Sayeed I, Neigh G, Stein D. Abstract WP150: Autophagy Regulates NLRP3 Inflammasome in Cerebral Ischemia With Comorbid Stress: A Protective Mechanism of Progesterone. Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.wp150.Peer-Reviewed Original ResearchLC3 punctaLC3-IIP62 levelsLC3-II levelsAutophagy inhibitorLC3 levelsIschemic animalsExposed to social defeat stressComorbid stressGlobal ischemiaMicroglial autophagyInflammatory responseCerebral ischemiaLC3Progesterone's protective effectsAutophagic fluxRodent models of cerebral ischemiaP62Social defeat stressExaggerated inflammatory responseAdult male ratsModels of cerebral ischemiaNLRP3 inflammasome overactivationNon-ischemic controlsTreated with progesterone
2018
Abstract WP101: Progesterone Counteracts Stress-Induced Microglial Priming by Reducing NLRP3 Inflammasome Activation After Ischemic Injury
Espinosa-Garcia C, Sayeed I, Atif F, Yousuf S, Neigh G, Stein D. Abstract WP101: Progesterone Counteracts Stress-Induced Microglial Priming by Reducing NLRP3 Inflammasome Activation After Ischemic Injury. Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.wp101.Peer-Reviewed Original ResearchSocial stressExposure to social stressExposed to social defeat stressSocial defeat stressNLRP3 inflammasome activationSensitive to stressInflammasome activationAdult male ratsGlobal ischemiaDefeat stressIschemic animalsComorbid stressIschemic injuryConsistent with previous reportsConsequences of cardiac arrestRelease of danger signalsNon-ischemic controlsMicroglial primingCaspase-1IL-1b levelsMale ratsDays post-ischemiaHippocampusCleaved caspase-1Poor outcome
2017
Abstract TP83: Stress Exacerbates Global Ischemia-induced Inflammatory Response: Intervention by Progesterone
Espinosa-Garcia C, Sayeed I, Yousuf S, Atif F, Sergeeva E, Neigh G, Stein D. Abstract TP83: Stress Exacerbates Global Ischemia-induced Inflammatory Response: Intervention by Progesterone. Stroke 2017, 48 DOI: 10.1161/str.48.suppl_1.tp83.Peer-Reviewed Original ResearchPro-inflammatory cytokinesNeuronal lossExposed to social defeat stressGlobal ischemiaIncreased brain-derived neurotrophic factor expressionInflammatory responsePost-ischemiaFactor expressionPost-ischemic inflammatory responseBrain-derived neurotrophic factor expressionAssociated with increased riskSocial defeat stressIschemia-induced inflammatory responseAdult male ratsAssociated with increased risk of strokeFour-vessel occlusion modelNeurotrophic factor expressionGrowth factor expressionHippocampal CA1 regionGlobal ischemic injuryActivation of microgliaExacerbated microglial activationRisk of strokeDays post-ischemiaDefeat stress
2016
Modulation of the peri‐infarct neurogliovascular function by delayed COX‐1 inhibition
Lake EMR, Mester J, Thomason LA, Adams C, Bazzigaluppi P, Koletar M, Janik R, Carlen P, McLaurin J, Stanisz GJ, Stefanovic B. Modulation of the peri‐infarct neurogliovascular function by delayed COX‐1 inhibition. Journal Of Magnetic Resonance Imaging 2016, 46: 505-517. PMID: 28703413, DOI: 10.1002/jmri.25541.Peer-Reviewed Original ResearchConceptsNeuronal survivalMicroglia/macrophage recruitmentExerts multiple beneficial effectsChronic ischemic injuryAdult male ratsCOX-1 inhibitionMultiple beneficial effectsMost patientsAstrocytic activationEndothelial densityNeuronal lossChronic stageFocal ischemiaHemodynamic changesIschemic injuryAdult disabilityMacrophage recruitmentMale ratsPerfusion responseMore effective interventionsNeurogliovascular unitCOX-1Novel treatmentsPerfusionBeneficial effects
2013
Effects of progesterone on neurite growth inhibitors in the hippocampus following global cerebral ischemia
Espinosa-García C, Aguilar-Hernández A, Cervantes M, Moralí G. Effects of progesterone on neurite growth inhibitors in the hippocampus following global cerebral ischemia. Brain Research 2013, 1545: 23-34. PMID: 24316245, DOI: 10.1016/j.brainres.2013.11.030.Peer-Reviewed Original ResearchConceptsEffects of progesteroneGlobal cerebral ischemiaMorris water mazeCA1 pyramidal neuronsNogo-ACerebral ischemiaPyramidal neuronsRho ACell bodies of CA1 pyramidal neuronsNeurite growth inhibitor Nogo-ASpatial learningVehicle-treated ratsAdult male ratsTreated with P4Effects of P4Dendritic arborization of CA1 pyramidal neuronsAssociated with parametersNeurite growth inhibitorsFunction preservationMale ratsRat hippocampusWater mazeIschemiaHippocampal layersRats
2011
Differential Acute and Chronic Effects of Leptin on Hypothalamic Astrocyte Morphology and Synaptic Protein Levels
García-Cáceres C, Fuente-Martín E, Burgos-Ramos E, Granado M, Frago LM, Barrios V, Horvath T, Argente J, Chowen JA. Differential Acute and Chronic Effects of Leptin on Hypothalamic Astrocyte Morphology and Synaptic Protein Levels. Endocrinology 2011, 152: 1809-1818. PMID: 21343257, PMCID: PMC3860256, DOI: 10.1210/en.2010-1252.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinChronic leptin exposureSynaptic inputsAstrocyte morphologyLeptin exposureGFAP levelsGlial structural proteinsSynaptic protein densityChronic leptin administrationAcute leptin treatmentSynaptic protein levelsAdult male ratsCentral leptin resistanceFibrillary acidic proteinLevels 1 hPossible direct effectGlial ensheathingNeonatal overnutritionGlial activationLeptin levelsLeptin administrationHypothalamic neuronsLeptin resistanceLeptin treatmentMale rats
2009
Mechanisms underlying age differences in dopaminergic drug sensitivity
Dwyer J, Buntrock L, Khalaj A, Martinez L, Leslie F. Mechanisms underlying age differences in dopaminergic drug sensitivity. The FASEB Journal 2009, 23: 745.3-745.3. DOI: 10.1096/fasebj.23.1_supplement.745.3.Peer-Reviewed Original ResearchNeural stress systemsCritical developmental periodAge differencesNeural circuitryAdolescenceDevelopmental periodBehavioral differencesBehavioral responsesStress systemDrug abuseIndirect dopamineStereotypic behaviorAdolescentsNeuropsychiatric disordersD2-like agonist quinpiroleImportant implicationsAdult male ratsImmediate early gene expressionAgonist quinpiroleReceptor changesAdulthoodMale ratsAbuseEarly gene expressionQuinpirole
2007
Bisphenol A Prevents the Synaptogenic Response to Testosterone in the Brain of Adult Male Rats
Leranth C, Szigeti-Buck K, MacLusky NJ, Hajszan T. Bisphenol A Prevents the Synaptogenic Response to Testosterone in the Brain of Adult Male Rats. Endocrinology 2007, 149: 988-994. PMID: 18048497, PMCID: PMC2275360, DOI: 10.1210/en.2007-1053.Peer-Reviewed Original ResearchConceptsAdult male ratsMedial prefrontal cortexMale ratsSpine synapsesCA1 hippocampal areaAsymmetric spine synapsesSham-operated animalsElectron microscopic stereologyImpairs synaptogenesisSynaptogenic actionsOvariectomized ratsHippocampal areaTestosterone supplementationTestosterone propionateEstrogen receptorExposure measurement dataOil vehicleCompensatory increaseIntact animalsSynthetic xenoestrogenPrefrontal cortexRatsHippocampusCastrated malesPotential mechanisms
2006
Androgen Effects on Hippocampal CA1 Spine Synapse Numbers Are Retained in Tfm Male Rats with Defective Androgen Receptors
MacLusky NJ, Hajszan T, Johansen JA, Jordan CL, Leranth C. Androgen Effects on Hippocampal CA1 Spine Synapse Numbers Are Retained in Tfm Male Rats with Defective Androgen Receptors. Endocrinology 2006, 147: 2392-2398. PMID: 16439462, DOI: 10.1210/en.2005-0673.Peer-Reviewed Original ResearchConceptsDefective androgen receptorHippocampal synaptic responsesEstradiol benzoateAndrogen receptorMale ratsSpine synapsesTfm malesSynaptic responsesAndrogen effectsTfm mutationEffects of EBDose of EBHippocampal CA1 synapsesSpine synapse numberSesame oil vehicleDendritic spine synapsesCA1 stratum radiatumAdult male ratsHippocampal spine synapsesVehicle-injected controlsHormone-induced increaseAgonists/antagonistsWild-type animalsWild-type malesCA1 synapses
2004
Neonatal isolation enhances maintenance but not reinstatement of cocaine self-administration in adult male rats
Zhang X, Sanchez H, Kehoe P, Kosten T. Neonatal isolation enhances maintenance but not reinstatement of cocaine self-administration in adult male rats. Psychopharmacology 2004, 177: 391-399. PMID: 15258719, DOI: 10.1007/s00213-004-1963-y.Peer-Reviewed Original ResearchConceptsAdult male ratsNeonatal isolationMale ratsCocaine-induced reinstatementPR scheduleCocaine dosesExtinguished self-administration behaviorLow cocaine dosesProgressive ratioEarly life stressNon-handled ratsSelf-administration behaviorAcquisition of cocaineDifferent cocaine dosesCocaine-seeking behaviorSelf-administer cocaineReinstatement of cocaineLow dosesRatsCocaineMore cocaineDosesLife stressGroup differencesSeparate groupsNeonatal isolation enhances acquisition of cocaine self-administration and food responding in female rats
Kosten T, Sanchez H, Zhang X, Kehoe P. Neonatal isolation enhances acquisition of cocaine self-administration and food responding in female rats. Behavioural Brain Research 2004, 151: 137-149. PMID: 15084429, DOI: 10.1016/j.bbr.2003.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAnimals, NewbornBehavior, AddictiveBody WeightCocaineConditioning, OperantDopamine Uptake InhibitorsDose-Response Relationship, DrugFeeding BehaviorFemaleMaleMotor ActivityRatsRats, Sprague-DawleyReinforcement ScheduleReinforcement, PsychologySelf AdministrationSex FactorsSocial Isolation
2000
Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats
Jain M, Horvath T, Kalra P, Kalra S. Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats. Peptides 2000, 87: 19-24. PMID: 10710284, DOI: 10.1016/s0167-0115(99)00102-0.Peer-Reviewed Original ResearchConceptsNeuropeptide YLateral hypothalamic areaArcuate nucleusY1 receptorParaventricular nucleusSelective NPY Y1 receptor antagonistNPY Y1 receptor antagonistNPY Y1 receptorY1 receptor antagonistStimulation of feedingAdult male ratsDose-dependent mannerOrexigenic peptideOrexin ANPY receptorsExcitatory effectsHypothalamic areaHypothalamic appetiteReceptor antagonistMale ratsSated ratsOrexinNeural sitesReceptorsNPYergic
1995
Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy
Du F, Eid T, Lothman E, Kohler C, Schwarcz R. Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. Journal Of Neuroscience 1995, 15: 6301-6313. PMID: 7472396, PMCID: PMC6577998, DOI: 10.1523/jneurosci.15-10-06301.1995.Peer-Reviewed Original ResearchConceptsPreferential neuronal lossTemporal lobe epilepsyNeuronal lossMedial entorhinal cortexEntorhinal cortexLayer IIILobe epilepsyRat modelIntractable temporal lobe epilepsyAcute status epilepticusLithium/pilocarpineParvalbumin-positive neuronsIntracellular calcium ion concentrationKainic acid administrationNerve cell lossAdult male ratsInjection of diazepamSurviving neuronsProlonged seizuresStatus epilepticusAcid administrationNissl stainingVentral hippocampusKainic acidPathological elevation
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