2021
Deficits in hippocampal-dependent memory across different rodent models of early life stress: systematic review and meta-analysis
Rocha M, Wang D, Avila-Quintero V, Bloch MH, Kaffman A. Deficits in hippocampal-dependent memory across different rodent models of early life stress: systematic review and meta-analysis. Translational Psychiatry 2021, 11: 231. PMID: 33879774, PMCID: PMC8058062, DOI: 10.1038/s41398-021-01352-4.Peer-Reviewed Original ResearchConceptsEarly life stressNovel object recognitionMorris water mazeDifferent rodent modelsContextual fear conditioningMaternal separationHippocampal-dependent memoryVentral hippocampusDorsal hippocampusRodent modelsLife stressAbnormal hippocampal developmentStandardized mean differenceSimilar cognitive deficitsWeb of ScienceModerate effect sizeCFC taskFunctional deficitsFear conditioningInclusion criteriaPreclinical studiesReduced freezingHippocampal developmentLimited beddingWater maze
2009
Altered response to antidepressant treatment in FoxG1 heterozygous knockout mice
Kinsler R, Taylor MM, Flores NM, Leffert JJ, Beech RD. Altered response to antidepressant treatment in FoxG1 heterozygous knockout mice. Synapse 2009, 64: 169-171. PMID: 19852072, PMCID: PMC2789865, DOI: 10.1002/syn.20737.Peer-Reviewed Original ResearchConceptsAdult hippocampal neurogenesisTail suspension testDifferent rodent modelsHeterozygous knockout miceForkhead box protein G1Heterozygous null miceRole of Foxg1Phosphatidyl inositol 3 kinaseContextual fear learningMechanism of actionAntidepressant actionHippocampal neurogenesisNeurogenic propertiesSwim testMood disordersRodent modelsSuspension testAntidepressantsKnockout miceLittermate controlsBehavioral abnormalitiesNull miceNormal levelsFOXG1 geneAltered response
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