2024
The evolution of patch-clamp electrophysiology: Robotic, multiplex, and dynamic
Ghovanloo M, Dib-Hajj S, Waxman S. The evolution of patch-clamp electrophysiology: Robotic, multiplex, and dynamic. Molecular Pharmacology 2024, 107: 100001. PMID: 39919159, DOI: 10.1124/molpharm.124.000954.Peer-Reviewed Original ResearchPatch-clamp techniquePatch-clamp electrophysiologyPatch clampVoltage- and current-clamp modesIon channelsContribution of ion channelsCurrent-clamp modePatch-clamp methodOhm's lawDynamic-clampGating mechanisms of ion channelsMuscle cellsCardiac excitabilityGold standardExcitable cellsReceptorsGate conductionElectrophysiologyNeuronsElectrogenesisSimultaneous recordingCellsHigh-throughput automated platformMechanisms of ion channelsGating mechanism
2022
Focal electrical stimulation of human retinal ganglion cells for vision restoration
Madugula S, Gogliettino A, Zaidi M, Aggarwal G, Kling A, Shah N, Brown J, Vilkhu R, Hays M, Nguyen H, Fan V, Wu E, Hottowy P, Sher A, Litke A, Silva R, Chichilnisky E. Focal electrical stimulation of human retinal ganglion cells for vision restoration. Journal Of Neural Engineering 2022, 19: 066040. PMID: 36533865, PMCID: PMC10010036, DOI: 10.1088/1741-2552/aca5b5.Peer-Reviewed Original ResearchConceptsHuman retinal ganglion cellsRetinal ganglion cellsElectrical stimulationVision restorationGanglion cellsExtracellular electrical stimulationPrimate retinal ganglion cellsFocal electrical stimulationRetina ex vivoRGC typesAxon bundlesEx vivoHuman retinaStimulationStimulation algorithmMulti-electrode arraysSimultaneous recordingEpiretinal implantsRetinaSimultaneous activationRetinal implantsCell typesNeural codeActivation propertiesMacaques
2009
Seizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model
Sunderam S, Chernyy N, Peixoto N, Mason J, Weinstein S, Schiff S, Gluckman B. Seizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model. Journal Of Neural Engineering 2009, 6: 046009. PMID: 19602730, PMCID: PMC3057918, DOI: 10.1088/1741-2560/6/4/046009.Peer-Reviewed Original ResearchConceptsField postsynaptic potentialsAnimal epilepsy modelsNeural activitySimultaneous recordingSpontaneous seizuresHippocampal epilepsyVentral hippocampusEpilepsy modelLocal field potentialsPostsynaptic potentialsNeuronal excitabilityNeuronal activityModulatory effectsAnimal modelsSeizuresStatistical significanceStimulationField potentialsMultiple presentationsAnimalsCharacteristic patternEpilepsyHippocampusRecordingsExcitability
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