2024
Surgical Approach to Patellofemoral Pain
Schneble C, Fulkerson J. Surgical Approach to Patellofemoral Pain. 2024, 1101-1117. DOI: 10.1007/978-3-031-29430-3_69.Peer-Reviewed Original ResearchPatellofemoral painSurgical treatmentTreatment of patellofemoral painPeripatellar soft tissuesAnterior knee painSource of painPain improvementPersistent painPain sourceSurgical approachNonsurgical treatmentSurgical interventionKnee painOrthopedic providersPainPatellofemoral syndromeRealignment proceduresAlleviate symptomsSoft tissue releaseSoft tissuePatellofemoral jointTissue releaseArticular cartilageTreatmentSubchondral boneSurgical Approach to Patellofemoral Pain
Schneble C, Fulkerson J. Surgical Approach to Patellofemoral Pain. 2024, 1-17. DOI: 10.1007/978-3-030-82869-1_69-1.ChaptersPatellofemoral painSurgical treatmentTreatment of patellofemoral painPeripatellar soft tissuesAnterior knee painSource of painPain improvementPersistent painPain sourceSurgical approachNonsurgical treatmentSurgical interventionKnee painOrthopedic providersPainPatellofemoral syndromeRealignment proceduresAlleviate symptomsSoft tissue releaseSoft tissuePatellofemoral jointTissue releaseArticular cartilageTreatmentSubchondral bone
2023
Three-Dimensional Printing of Models of Patellofemoral Joint Articular Cartilage in Patients With Patella Instability for Observing Joint Congruity
Beitler B, Kunsel K, Yu K, Wang A, Tommasini S, Wiznia D, Fulkerson J. Three-Dimensional Printing of Models of Patellofemoral Joint Articular Cartilage in Patients With Patella Instability for Observing Joint Congruity. Arthroscopy Techniques 2023, 12: e1853-e1858. PMID: 37942111, PMCID: PMC10628265, DOI: 10.1016/j.eats.2023.06.016.Peer-Reviewed Original ResearchBiomechanical Impact of Phosphate Wasting on Articular Cartilage Using the Murine Hyp Model of X‐linked hypophosphatemia
Macica C, Tommasini S. Biomechanical Impact of Phosphate Wasting on Articular Cartilage Using the Murine Hyp Model of X‐linked hypophosphatemia. JBMR Plus 2023, 7: e10796. PMID: 37808393, PMCID: PMC10556269, DOI: 10.1002/jbm4.10796.Peer-Reviewed Original ResearchWT miceHyp miceMechanical propertiesArticular cartilageTrabecular bone volumeProgression of osteoarthritisEtiology of osteoarthritisRange of motionSubchondral bone plateOral phosphateDegenerative osteoarthritisTibial articular cartilageDaily livingAC stiffnessBone volumeTherapeutic restorationOsteoarthritisStructural stiffnessCompressive loadingMicePeak loadTherapyCellular changesMineral deficitStress relaxationAdvances in Cartilage Repair
Azam M, Butler J, Duenes M, McAllister T, Walls R, Gianakos A, Kennedy J. Advances in Cartilage Repair. Orthopedic Clinics Of North America 2023, 54: 227-236. PMID: 36894294, DOI: 10.1016/j.ocl.2022.11.007.Peer-Reviewed Original ResearchConceptsAutologous osteochondral transplantationBone marrow stimulationPoor healing capacityAnkle painUncontained lesionsConservative managementArthroscopic debridementCystic lesionsBiological adjuvantsTraumatic etiologyOsteochondral transplantationInvasive proceduresOsteochondral lesionsLarge lesionsMarrow stimulationAnkle jointLesionsSmall lesionsScaffold-based therapiesHealing capacityPatientsArticular cartilageUnsatisfactory resultsCartilage repairDebridement
2022
Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation
Kwon HK, Dussik CM, Kim SH, Kyriakides TR, Oh I, Lee FY. Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation. Frontiers In Cellular And Infection Microbiology 2022, 12: 897291. PMID: 35755835, PMCID: PMC9218192, DOI: 10.3389/fcimb.2022.897291.Peer-Reviewed Original ResearchConceptsSeptic arthritisBacterial burdenAntibiotic treatmentMurine modelTherapeutic goalsConcurrent antimicrobial therapyDistinct therapeutic goalsGeneration of inflammationMRSA septic arthritisSeptic knee arthritisInflammatory joint conditionsArticular cartilageMitigation of inflammationPost-antibiotic treatmentNovel therapeutic strategiesSeptic arthritis modelArticular cartilage damageEx vivo modelArticular cartilage integrityInflammatory arthritisInhibitors of ERKInflammatory profileMRSA infectionSynovial tissueExcessive inflammationArthroscopic Patellar Osteochondral Transplantation
Hsu J, Linhoff J. Arthroscopic Patellar Osteochondral Transplantation. Arthroscopy Techniques 2022, 11: e475-e481. PMID: 35256994, PMCID: PMC8897650, DOI: 10.1016/j.eats.2021.11.017.Peer-Reviewed Original Research
2021
A 24-Year-Old Female with Anterior Knee Pain, Normal Looking Cartilage, and Mild Malalignment
Aitchison A, Fulkerson J, Tompkins M, Green D. A 24-Year-Old Female with Anterior Knee Pain, Normal Looking Cartilage, and Mild Malalignment. 2021, 161-164. DOI: 10.1007/978-3-030-81545-5_16.Peer-Reviewed Original ResearchInfluence of pore sizes in 3D-scaffolds on mechanical properties of scaffolds and survival, distribution, and proliferation of human chondrocytes
Abpeikar Z, Milan P, Moradi L, Anjomshoa M, Asadpour S. Influence of pore sizes in 3D-scaffolds on mechanical properties of scaffolds and survival, distribution, and proliferation of human chondrocytes. Mechanics Of Advanced Materials And Structures 2021, 29: 4911-4922. DOI: 10.1080/15376494.2021.1943077.Peer-Reviewed Original ResearchDual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis
Kwon HK, Lee I, Yu KE, Cahill SV, Alder KD, Lee S, Dussik CM, Back J, Choi J, Song L, Kyriakides TR, Lee FY. Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis. Science Advances 2021, 7: eabf2665. PMID: 34172438, PMCID: PMC8232912, DOI: 10.1126/sciadv.abf2665.Peer-Reviewed Original ResearchConceptsIntra-articular inflammationSeptic arthritisBacterial infectionsDual therapeutic targetingKnee septic arthritisPromising new therapeutic strategyArticular cartilageChallenging clinical problemNovel treatment modalitiesIntracellular bacteriaNew therapeutic strategiesAdjuvant targetingTreatment modalitiesBacterial eradicationSuccessful treatmentHost inflammationCausative bacteriaMurine modelTherapeutic strategiesArthritisTherapeutic goalsClinical problemTherapeutic targetingInflammationVital organs
2020
Current Concepts Regarding Patellofemoral Trochlear Dysplasia
Levy BJ, Tanaka MJ, Fulkerson JP. Current Concepts Regarding Patellofemoral Trochlear Dysplasia. The American Journal Of Sports Medicine 2020, 49: 1642-1650. PMID: 33021814, DOI: 10.1177/0363546520958423.Peer-Reviewed Original ResearchConceptsRecurrent patellar instabilityTrochlear dysplasiaPatellar instabilityPatellofemoral jointMedial quadriceps tendon-femoral ligamentMajority of patientsTibial tubercle transferMajority of casesArticular cartilageSurgical stabilizationMedial patellofemoralOptimal treatmentTubercle transferDysplasiaPatientsComplex structural anomaliesPatellofemoral trackingSurgical planningTrochleoplastyStructural anomaliesSpecific deficitsCartilagePatellofemoralMajority
2017
Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic mice
Mirza F, Lorenzo J, Drissi H, Lee FY, Soung DY. Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic mice. The Journal Of Nutritional Biochemistry 2017, 52: 54-61. PMID: 29149648, DOI: 10.1016/j.jnutbio.2017.10.002.Peer-Reviewed Original ResearchConceptsTumor necrosis factorTransgenic miceRheumatoid arthritisNuclear factor-kappa B activationDP dietBone-preserving propertiesReduction of synovitisPresence of TNFFour-week treatmentOnset of arthritisResistant acid phosphatase-positive cellsAcid phosphatase-positive cellsDestruction of jointsHuman synovial fibroblastsTNF-transgenic miceHuman tumor necrosis factorKappa B activationActivated T cellsFormation of osteoclastsMouse bone marrow macrophagesBone marrow macrophagesArticular cartilagePostmenopausal womenInflammatory arthritisBone erosionWhole grape alleviates inflammatory arthritis through inhibition of tumor necrosis factor
Stamer D, Nizami S, Lee F, Soung Y. Whole grape alleviates inflammatory arthritis through inhibition of tumor necrosis factor. Journal Of Functional Foods 2017, 35: 458-465. DOI: 10.1016/j.jff.2017.06.018.Peer-Reviewed Original ResearchTumor necrosis factorTransgenic miceRheumatoid arthritisTg miceNecrosis factorMacrophage inflammatory protein-1 alphaInflammatory protein-1 alphaAnti-rheumatic efficacySynovitis/enthesitisGP dietProtein-1 alphaHuman tumor necrosis factorRA symptomsInflammatory arthritisRegular dietBone massOsteoclastogenic factorsPowder dietMatrix metalloproteinasesMiceArthritisDietArticular cartilageWhole grapesGPs
2014
Anteromedial Tibial Tubercle Transfer
Fulkerson J. Anteromedial Tibial Tubercle Transfer. 2014, 151-153. DOI: 10.1007/978-3-642-54965-6_20.Peer-Reviewed Original ResearchAnteromedial tibial tubercle transferTibial tubercle transferExcessive lateral pressure syndromeTubercle transferArticular cartilageChronic painArticular damageMedial patellaLateral patellaProximal aspectEarly flexionDistal aspectArticular lesionsClassic patientsLateral trochleaPatientsPatellaLateral articular cartilageLateral positionCartilageLateral facetVast majorityLateral trackingTypical patternFicat
2012
Lead induces an osteoarthritis‐like phenotype in articular chondrocytes through disruption of TGF‐β signaling
Holz JD, Beier E, Sheu T, Ubayawardena R, Wang M, Sampson ER, Rosier RN, Zuscik M, Puzas JE. Lead induces an osteoarthritis‐like phenotype in articular chondrocytes through disruption of TGF‐β signaling. Journal Of Orthopaedic Research® 2012, 30: 1760-1766. PMID: 22517267, PMCID: PMC3839422, DOI: 10.1002/jor.22117.Peer-Reviewed Original ResearchConceptsLead treatmentOsteoarthritis-like phenotypeNormal chondrocyte phenotypeDose-dependent mannerArticular chondrocytesTGF-β signalingActive caspase-3MMP13 activityLead exposureHigher level leadType II collagenVivo exposureCollagen levelsNovel targetType X collagenCaspase-3Articular surfaceEnvironmental toxinsLead toxicityII collagenReporter activityTreatmentArticular cartilageDosePhenotypic shift
2011
Genetic evidence of the regulatory role of parathyroid hormone–related protein in articular chondrocyte maintenance in an experimental mouse model
Macica C, Liang G, Nasiri A, Broadus AE. Genetic evidence of the regulatory role of parathyroid hormone–related protein in articular chondrocyte maintenance in an experimental mouse model. Arthritis & Rheumatism 2011, 63: 3333-3343. PMID: 21702022, PMCID: PMC3197958, DOI: 10.1002/art.30515.Peer-Reviewed Original ResearchConceptsHormone-related proteinDegenerative changesKO miceParathyroid hormone-related proteinMale KO miceExperimental mouse modelMouse articular cartilageTotal histologic scoreIndian hedgehogTibial articular surfaceArticular chondrocytesArticular cartilageGrowth differentiation factor 5Degenerative findingsControl miceHistologic scoresMouse modelCompensatory increaseTime-course studyDifferentiation factor 5PTHrPRegulatory roleMiceConditional deletionChondrocyte maintenance
2009
Effects of multiple chondroitinase ABC applications on tissue engineered articular cartilage
Natoli R, Responte D, Lu B, Athanasiou K. Effects of multiple chondroitinase ABC applications on tissue engineered articular cartilage. Journal Of Orthopaedic Research® 2009, 27: 949-956. PMID: 19123232, PMCID: PMC2819396, DOI: 10.1002/jor.20821.Peer-Reviewed Original ResearchConceptsCartilage tissue engineeringArticular cartilage tissue engineeringIncreased tensile propertiesTensile propertiesTissue engineeringTissue engineered articular cartilageAbundant collagen type IITensile biomechanical propertiesIncreased tensile stiffnessTensile modulusCollagen type IITensile stiffnessTensile strengthCompressive stiffnessArticular cartilageC-ABCTensileSulfated GAG compositionEngineeringStiffnessPropertiesCollagen type I.Collagen compositionCartilageBiomechanical properties
2008
Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone–related protein in mice
Chen X, Macica CM, Nasiri A, Broadus AE. Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone–related protein in mice. Arthritis & Rheumatism 2008, 58: 3788-3797. PMID: 19035497, PMCID: PMC2599803, DOI: 10.1002/art.23985.Peer-Reviewed Original ResearchConceptsPTHrP expressionParathyroid hormone-related proteinArticular cartilagePTHrP-knockout micePathogenesis of arthritisWeight-bearing jointsHormone-related proteinChondrocyte proliferationIndian hedgehogGrowth plate structureCell of originArticular chondrocytesEpiphyseal growth zoneSecondary ossification centerArticular chondrocyte differentiationArticular chondrocyte proliferationAdult miceAxis participatesKnockin miceMicePTHrPProtein axisOssification centersIhhCartilage
2007
Demonstration of Multipotent Stem Cells in the Adult Human Endometrium by In Vitro Chondrogenesis
Wolff EF, Wolff AB, Du H, Taylor HS. Demonstration of Multipotent Stem Cells in the Adult Human Endometrium by In Vitro Chondrogenesis. Reproductive Sciences 2007, 14: 524-533. PMID: 17959881, DOI: 10.1177/1933719107306896.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsMultipotent stem cellsFallopian tubeType II collagenStem cellsReproductive-aged womenHuman articular cartilageEndometrial stem cellsAdult human endometriumII collagenMultilineage differentiationArticular cartilageBenign diseaseEndometrial tissueExtramedullary tissuesHuman endometriumCell pelletsEndometriumChondrogenic mediumStromal cellsLigament cellsSulfated glycosaminoglycansGrowth factorProgenitor cellsCell types
2003
Knee Articular Cartilage Development in Children: A Longitudinal Study of the Effect of Sex, Growth, Body Composition, and Physical Activity
Jones G, Ding C, Glisson M, Hynes K, Ma D, Cicuttini F. Knee Articular Cartilage Development in Children: A Longitudinal Study of the Effect of Sex, Growth, Body Composition, and Physical Activity. Pediatric Research 2003, 54: 230-236. PMID: 12736391, DOI: 10.1203/01.pdr.0000072781.93856.e6.Peer-Reviewed Original ResearchConceptsArticular cartilage volumePhysical activityCartilage volumeTanner stageEffects of sexPhysical activity associationsArticular cartilageLateral tibial compartmentHigh accrual rateOverweight childrenMedial tibialArticular cartilage developmentTibial compartmentBody compositionVigorous sportsMost childrenFemale childrenTibialNormal childrenWeight changeActivity associationsCartilage developmentLater lifeAverage intervalAccrual rate
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