2024
International multi-institutional external validation of preoperative risk scores for 30-day in-hospital mortality in paediatric patients
Tangel V, Hoeks S, Stolker R, Brown S, Pryor K, de Graaff J, Committee M, Pace N, Domino K, Muehlschlegel J, Kheterpal S, Vaughan M, Mathis M, Jiang S, Obembe S, Freundlich R, Schonberger R, Kim D. International multi-institutional external validation of preoperative risk scores for 30-day in-hospital mortality in paediatric patients. British Journal Of Anaesthesia 2024, 133: 1222-1233. PMID: 39477712, DOI: 10.1016/j.bja.2024.09.003.Peer-Reviewed Original ResearchConceptsSurgical risk scoresPediatric risk assessmentArea under the receiver operating characteristic curveIn-Hospital MortalityRisk scoreMulticenter Perioperative Outcomes GroupPreoperative risk scoreDecision curve analysisReceiver operating characteristic curvePhysical status scoreExternal validationAssess model discriminationRisk prediction scoreASA physical status scoreClinical decision-makingPaediatric patientsLow probability of mortalityDutch hospitalsOutcome groupPatient-specific risk scoresPrimary outcomeClustering of casesCurve analysisStatus scoreCharacteristic curve
2023
A phase 2 expansion study of ARV-766, a PROTAC androgen receptor (AR) degrader, in metastatic castration-resistant prostate cancer (mCRPC).
Petrylak D, Stewart T, Gao X, Berghorn E, Lu H, Chan E, Gedrich R, Lang J, McKean M. A phase 2 expansion study of ARV-766, a PROTAC androgen receptor (AR) degrader, in metastatic castration-resistant prostate cancer (mCRPC). Journal Of Clinical Oncology 2023, 41: tps290-tps290. DOI: 10.1200/jco.2023.41.6_suppl.tps290.Peer-Reviewed Original ResearchMetastatic castration-resistant prostate cancerNovel hormonal agentsCohort expansionDisease progressionEastern Cooperative Oncology Group performance status scoreOngoing androgen deprivation therapyProstate-specific antigen (PSA) declineCastration-resistant prostate cancerGonadotropin-releasing hormone analogueCohort expansion studyAndrogen deprivation therapyPerformance status scoreOverall response ratePhase 1 portionWild-type ARDeprivation therapyPrior chemotherapyCurative optionDose escalationAvailable therapiesHormonal agentsStatus scoreCurrent therapiesLigand-binding domainClinical trials
2021
Identification of Hospitals That Care for a High Proportion of Patients With Social Risk Factors
Matty R, Heckmann R, George E, Barthel AB, Suter LG, Ross JS, Bernheim SM. Identification of Hospitals That Care for a High Proportion of Patients With Social Risk Factors. JAMA Health Forum 2021, 2: e211323. PMID: 35977204, PMCID: PMC8796989, DOI: 10.1001/jamahealthforum.2021.1323.Peer-Reviewed Original ResearchConceptsSocial risk factorsIdentification of hospitalsProportion of patientsRisk factorsCross-sectional studyHospital performance measuresPatient populationHospital Readmissions Reduction ProgramAfrican American raceProportion of hospitalsDisadvantaged patient populationsReadmissions Reduction ProgramHigher proportionSocioeconomic status scoresSame hospitalStatus scoreCrowded householdsMAIN OUTCOMEMedicaid coverageAmerican racePatientsHospitalHealthcare ResearchDisadvantaged populationsSuch hospitals
2020
Patient profiles and health status outcomes for peripheral artery disease in high-income countries: a comparison between the USA and The Netherlands
Jelani QU, Smolderen KG, Halpin D, Gosch K, Spertus JA, Chaar C, Nolthenius R, Heyligers J, De Vries JP, Mena-Hurtado C. Patient profiles and health status outcomes for peripheral artery disease in high-income countries: a comparison between the USA and The Netherlands. European Heart Journal - Quality Of Care And Clinical Outcomes 2020, 7: 505-512. PMID: 32539108, DOI: 10.1093/ehjqcco/qcaa052.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseHealth status scoresHealth status outcomesStatus scoreStatus outcomesArtery diseaseUS patientsHigh-income countriesPatient profilesCardiovascular risk factor burdenPAD-specific health statusPeripheral Artery QuestionnaireRisk factor burdenVascular specialty clinicsPeripheral arterial diseasePatient-centered outcomesLow referral ratesMore financial barriersPAD carePAD outcomesNew onsetPAD symptomsArterial diseaseExercise treatmentReferral ratesHaving a Primary Care Provider is the Strongest Predictor of Successful Follow-up of Participants in a Clinical Trial
Friedman S, Cunningham C, Lin J, Haramati L, Levsky J. Having a Primary Care Provider is the Strongest Predictor of Successful Follow-up of Participants in a Clinical Trial. The Journal Of The American Board Of Family Medicine 2020, 33: 431-439. PMID: 32430375, DOI: 10.3122/jabfm.2020.03.190018.Peer-Reviewed Original ResearchConceptsPrimary care physiciansClinical trialsCare providersHigher Charlson Comorbidity Index scoresMultivariate analysisCharlson Comorbidity Index scoreProspective randomized control trialBivariate analysisComorbidity Index scoreChest pain patientsPrimary care providersHealth care providersRandomized control trialLow socioeconomic statusSocioeconomic status scoresHealth care systemPain patientsPatient characteristicsCare physiciansInsurance statusStatus scoreMedical historyFollow-upControl trialIndex scoreComorbid vision and cognitive impairments in older adults hospitalized for acute myocardial infarction
Whitson HE, Hajduk AM, Song X, Geda M, Tsang S, Brush J, Chaudhry SI. Comorbid vision and cognitive impairments in older adults hospitalized for acute myocardial infarction. Journal Of Multimorbidity And Comorbidity 2020, 10: 2235042x20940493. PMID: 32728552, PMCID: PMC7366400, DOI: 10.1177/2235042x20940493.Peer-Reviewed Original ResearchAcute myocardial infarctionCognitive impairmentVision impairmentAMI patientsMyocardial infarctionOlder AMI patientsProspective cohort studyComorbid cognitive impairmentCognitive status scoresAMI presentationOlder patientsADL declineCohort studyGeriatric syndromesStatus scoreDaily livingAdjusted modelPatientsVision statusCI groupTelephone interviewsOlder adultsImpairmentInfarctionHigh rate
2019
Association of Diabetes Mellitus With Health Status Outcomes in Young Women and Men After Acute Myocardial Infarction: Results From the VIRGO Study
Ding Q, Funk M, Spatz ES, Whittemore R, Lin H, Lipska KJ, Dreyer RP, Spertus JA, Krumholz HM. Association of Diabetes Mellitus With Health Status Outcomes in Young Women and Men After Acute Myocardial Infarction: Results From the VIRGO Study. Journal Of The American Heart Association 2019, 8: e010988. PMID: 31441351, PMCID: PMC6755841, DOI: 10.1161/jaha.118.010988.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsDiabetes MellitusFemaleHealth StatusHealth Status IndicatorsHumansMaleMental HealthMiddle AgedMyocardial InfarctionPatient Reported Outcome MeasuresPredictive Value of TestsPrevalencePrognosisQuality of LifeRecovery of FunctionRisk AssessmentRisk FactorsSex FactorsSpainTime FactorsUnited StatesYoung AdultConceptsAcute myocardial infarctionEuroQol visual analogue scaleSeattle Angina QuestionnaireDiabetes mellitusForm Health SurveyHealth status outcomesHealth statusVIRGO StudyAnalog scaleMyocardial infarctionHealth SurveyStatus outcomesYoung adultsSAQ angina frequencyCardiovascular risk factorsHealth status scoresRisk of mortalityWorse health statusPoor health statusQuality of lifeWorse anginaAngina QuestionnaireClinical characteristicsHealthcare useStatus score
2018
Sex Differences in Omega‐3 and ‐6 Fatty Acids and Health Status Among Young Adults With Acute Myocardial Infarction: Results From the VIRGO Study
Lu Y, Ding Q, Xu X, Spatz ES, Dreyer RP, D'Onofrio G, Caulfield M, Nasir K, Spertus JA, Krumholz HM. Sex Differences in Omega‐3 and ‐6 Fatty Acids and Health Status Among Young Adults With Acute Myocardial Infarction: Results From the VIRGO Study. Journal Of The American Heart Association 2018, 7: e008189. PMID: 29848494, PMCID: PMC6015388, DOI: 10.1161/jaha.117.008189.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHealth status scoresArachidonic acidVIRGO StudyStatus scoreMyocardial infarctionHealth statusPoorer health status outcomesYoung menPatient-reported health statusYoung womenOmega-3 fatty acidsSex differencesPatient-reported outcomesFatty acidsHealth status outcomesCardiovascular outcomesClinical characteristicsAdjusted analysisAMI patientsRisk factorsUS adultsStatus outcomesOmega-3Women 1
2015
Lack of Association Between Costs of Care and Overall Survival (OS) Among Medicare Beneficiaries with Myelodysplastic Syndromes (MDS) in the United States (US)
Zeidan A, Wang R, Davidoff A, Gore S, Soulos P, Huntington S, Gross C, Ma X. Lack of Association Between Costs of Care and Overall Survival (OS) Among Medicare Beneficiaries with Myelodysplastic Syndromes (MDS) in the United States (US). Blood 2015, 126: 873. DOI: 10.1182/blood.v126.23.873.873.Peer-Reviewed Original ResearchDisability Status ScoreOverall survivalMyelodysplastic syndromeMDS patientsCost of careStudy cohortLack of associationHistologic subtypeStatus scoreMedicare beneficiariesEnd Results-Medicare databaseProportional hazards regression modelsOverall study cohortMedian overall survivalOutcomes of patientsElixhauser comorbidity scoreDate of diagnosisEntire study cohortKaplan-Meier methodHazards regression modelsDisease-related costsNon-white raceEnd of studyDate of deathMedicare Part AOne Year Health Status Benefits Following Treatment for New Onset or Exacerbation of Peripheral Arterial Disease Symptoms: The Importance of Patients' Baseline Health Status
van Zitteren M, Denollet J, Heyligers JM, Elshof JW, Nooren MJ, Burger DH, de Fijter WM, Vriens PW, Smolderen KG. One Year Health Status Benefits Following Treatment for New Onset or Exacerbation of Peripheral Arterial Disease Symptoms: The Importance of Patients' Baseline Health Status. European Journal Of Vascular And Endovascular Surgery 2015, 50: 213-222. PMID: 26036809, DOI: 10.1016/j.ejvs.2015.04.003.Peer-Reviewed Original ResearchMeSH KeywordsAgedDisease ProgressionFemaleHealth StatusHealth Status IndicatorsHumansLinear ModelsMaleMental HealthMiddle AgedNetherlandsPeripheral Arterial DiseasePredictive Value of TestsPropensity ScoreProspective StudiesRecovery of FunctionRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeUltrasonography, Doppler, DuplexConceptsHealth status scoresPeripheral arterial diseaseHealth status gainsBaseline health statusInvasive treatmentStatus scoreHealth statusPatient's baseline health statusPeripheral arterial disease symptomsHealth status levelsHealth status outcomesNew onsetPAD symptomsVascular clinicArterial diseaseHighest quartilePCS scoresInvasive strategyTreatment strategiesClinical informationStatus outcomesPatientsLinear regression analysisChange scoresExacerbationGender Differences in the Trajectory of Recovery in Health Status Among Young Patients With Acute Myocardial Infarction
Dreyer RP, Wang Y, Strait KM, Lorenze NP, D'Onofrio G, Bueno H, Lichtman JH, Spertus JA, Krumholz HM. Gender Differences in the Trajectory of Recovery in Health Status Among Young Patients With Acute Myocardial Infarction. Circulation 2015, 131: 1971-1980. PMID: 25862743, PMCID: PMC4657729, DOI: 10.1161/circulationaha.114.014503.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHealth status scoresHealth statusMyocardial infarctionStatus scoreMedical record abstractionMental summary scoresShort Form-12Disease-specific measuresHealth status measuresWomen's health statusYears of ageLower health status scoresLinear mixed-effects analysisPatients 18Younger patientsRecord abstractionForm-12Excess riskMixed-effects analysisPatient interviewsSpanish hospitalsBaseline hospitalizationSummary scoresGender differences
2001
UPBEAT: The Impact of a Psychogeriatric Intervention in VA Medical Centers
Kominski G, Andersen R, Bastani R, Gould R, Hackman C, Huang D, Jarvik L, Maxwell A, Moye J, Olsen E, Rohrbaugh R, Rosansky J, Taylor S, Van Stone W. UPBEAT: The Impact of a Psychogeriatric Intervention in VA Medical Centers. Medical Care 2001, 39: 500-512. PMID: 11317098, DOI: 10.1097/00005650-200105000-00010.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlcoholismAnalysis of VarianceAnxiety DisordersComorbidityContinuity of Patient CareCost-Benefit AnalysisDepressive DisorderFemaleFollow-Up StudiesGeriatric AssessmentGeriatric PsychiatryHealth StatusHospitals, VeteransHumansMaleMass ScreeningMental HealthMental Health ServicesMiddle AgedOutcome Assessment, Health CarePatient Care TeamProgram EvaluationPsychiatric Status Rating ScalesUnited StatesUnited States Department of Veterans AffairsVeteransConceptsCare coordinationGeneral health status scoresHealth Survey Short FormMental healthAmbulatory psychiatric servicesAlcohol Use Disorders Identification Test (AUDIT) scoresHealth status scoresGeneral health statusVA Medical CenterComorbid psychiatric conditionsMental health treatmentNonpsychiatric admissionsUsual careReadmission ratesSurgical treatmentOutpatient costsInpatient costsStatus scoreBed daysComorbid depressionInpatient useOutpatient careElderly veteransInpatient daysMedical Center
1995
The influence of socioeconomic status on change in health status after hospitalization
Guadagnoli E, Cleary P, Mcneil B. The influence of socioeconomic status on change in health status after hospitalization. Social Science & Medicine 1995, 40: 1399-1406. PMID: 7638648, DOI: 10.1016/0277-9536(94)00266-v.Peer-Reviewed Original ResearchConceptsHigh-SES patientsHigh-income patientsHealth statusChest painSurgical patientsHospital recordsSocioeconomic statusDaily livingUniversity-affiliated teaching hospitalLow-SES patientsHealth status scoresPatients' hospital recordsWorse health statusHospital dischargeHospital admissionStatus scoreTeaching hospitalInstrumental activitiesPatientsBasic activitiesHospitalizationPainAmount of declineAdmissionVariety of outcomes
1994
ASA Physical Status and Age Predict Morbidity After Three Surgical Procedures
Cullen D, Apolone G, Greenfield S, Guadagnoli E, Cleary P. ASA Physical Status and Age Predict Morbidity After Three Surgical Procedures. Annals Of Surgery 1994, 220: 3-9. PMID: 8024356, PMCID: PMC1234280, DOI: 10.1097/00000658-199407000-00002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAnalysis of VarianceAnesthesiologyCaliforniaCholecystectomyDiagnosis-Related GroupsFemaleFollow-Up StudiesHip ProsthesisHospitals, TeachingHumansLength of StayMaleMassachusettsMiddle AgedMorbidityOffice VisitsPostoperative ComplicationsPrognosisProstatectomySeverity of Illness IndexSocieties, MedicalConceptsLength of stayASA-PS scoreTotal hip replacementComplication rateTransurethral prostatectomySurgical patientsAnesthesiologists physical status scoreLonger LOSPreoperative risk factorsPostoperative complication rateASA physical statusPhysician office visitsHigh complication rateCase-mix differencesAcademic medical centerSelf-administered questionnairePostoperative morbidityCoexistent diseasePhysician visitsSurgical morbidityOffice visitsStatus scoreMedical recordsRisk factorsMedical CenterDifferences between men and women undergoing major orthopedic surgery for degenerative arthritis
Katz J, Wright E, Guadagnoli E, Liang M, Karlson E, Cleary P. Differences between men and women undergoing major orthopedic surgery for degenerative arthritis. Arthritis & Rheumatism 1994, 37: 687-694. PMID: 8185695, DOI: 10.1002/art.1780370512.Peer-Reviewed Original ResearchConceptsMajor orthopedic surgeryWorse functional statusFunctional status scoresFunctional statusSpinal stenosisDegenerative arthritisClinical characteristicsStatus scoreOrthopedic surgeryPreoperative functional status scoreDegenerative lumbar spinal stenosisAdvanced degenerative arthritisTime of laminectomyOutcome of surgeryDegenerative spinal stenosisLumbar spinal stenosisBody mass indexGreater functional improvementTotal knee arthroplastyTotal joint arthroplastyTotal hip arthroplastySelf-administered questionnaireHospital complicationsConsecutive patientsComorbid conditions
1986
Fall risk index for elderly patients based on number of chronic disabilities
Tinetti M, Williams T, Mayewski R. Fall risk index for elderly patients based on number of chronic disabilities. The American Journal Of Medicine 1986, 80: 429-434. PMID: 3953620, DOI: 10.1016/0002-9343(86)90717-5.Peer-Reviewed Original ResearchConceptsFall risk scoreRecurrent fallersRisk factorsElderly personsDaily living scorePostural blood pressureFall risk indexMental status scoresIntermediate care facilitiesBack examinationRecurrent fallingElderly patientsLiving scoreBlood pressureChronic disabilityStatus scoreConsecutive admissionsMobility scoreRisk scoreCare facilitiesDistant visionDisability increasesRisk indexMobility testsChronic characteristics
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