2022
Are risk factors necessary for pretest probability assessment of coronary artery disease? A patient similarity network analysis of the PROMISE trial
Kolossváry M, Mayrhofer T, Ferencik M, Karády J, Pagidipati NJ, Shah SH, Nanna MG, Foldyna B, Douglas PS, Hoffmann U, Lu MT. Are risk factors necessary for pretest probability assessment of coronary artery disease? A patient similarity network analysis of the PROMISE trial. Journal Of Cardiovascular Computed Tomography 2022, 16: 397-403. PMID: 35393245, PMCID: PMC9452442, DOI: 10.1016/j.jcct.2022.03.006.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseCoronary CT angiographyCalcium scoreRisk factorsLuminal narrowingPTP scoreArtery diseasePatient characteristicsPROMISE trialStable chest pain patientsObstructive coronary artery diseasePretest probability assessmentChest pain patientsSimilar risk profilesCT angiographyImaging markerRisk profileDiagnostic accuracyCAD predictionSex groupsProbability calculatorScoresSubanalysesDiseaseGroup individuals
2021
Estimating the real-world performance of the PROMISE minimal-risk tool
Nanna MG, Wang TY, Chiswell K, Sun JL, Vemulapalli S, Hoffmann U, Patel MR, Udelson JE, Fordyce CB, Douglas PS. Estimating the real-world performance of the PROMISE minimal-risk tool. American Heart Journal 2021, 239: 100-109. PMID: 34077743, DOI: 10.1016/j.ahj.2021.05.016.Peer-Reviewed Original ResearchMeSH KeywordsAngina, StableComputed Tomography AngiographyCoronary AngiographyCoronary StenosisCoronary VesselsFemaleHeart Disease Risk FactorsHumansMaleMedical OveruseMiddle AgedMyocardial InfarctionMyocardial RevascularizationOutcome and Process Assessment, Health CarePrognosisRisk AssessmentUnited StatesConceptsObstructive coronary artery diseaseNon-low risk patientsLow-risk patientsCoronary artery diseaseStable chest painRisk patientsCardiac catheterizationArtery diseaseChest painMyocardial infarctionLower riskProspective Multicenter Imaging StudyStable chest pain patientsCardiovascular adverse outcomesMI-free survivalChest pain patientsObstructive coronary diseaseElective cardiac catheterizationLikelihood of freedomLogistic regression modelingOutcomes of interestPositive predictive valueAlternative cut pointsIndex angiographyIndex catheterization
2020
Having a Primary Care Provider is the Strongest Predictor of Successful Follow-up of Participants in a Clinical Trial
Friedman S, Cunningham C, Lin J, Haramati L, Levsky J. Having a Primary Care Provider is the Strongest Predictor of Successful Follow-up of Participants in a Clinical Trial. The Journal Of The American Board Of Family Medicine 2020, 33: 431-439. PMID: 32430375, DOI: 10.3122/jabfm.2020.03.190018.Peer-Reviewed Original ResearchConceptsPrimary care physiciansClinical trialsCare providersHigher Charlson Comorbidity Index scoresMultivariate analysisCharlson Comorbidity Index scoreProspective randomized control trialBivariate analysisComorbidity Index scoreChest pain patientsPrimary care providersHealth care providersRandomized control trialLow socioeconomic statusSocioeconomic status scoresHealth care systemPain patientsPatient characteristicsCare physiciansInsurance statusStatus scoreMedical historyFollow-upControl trialIndex score
2018
Prognostic Accuracy of the HEART Score for Prediction of Major Adverse Cardiac Events in Patients Presenting With Chest Pain: A Systematic Review and Meta‐analysis
Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Thiruganasambandamoorthy V, Kyeremanteng K, Perry JJ. Prognostic Accuracy of the HEART Score for Prediction of Major Adverse Cardiac Events in Patients Presenting With Chest Pain: A Systematic Review and Meta‐analysis. Academic Emergency Medicine 2018, 26: 140-151. PMID: 30375097, DOI: 10.1111/acem.13649.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsPrediction of MACEAdverse cardiac eventsHEART scorePrediction of mortalityChest painMyocardial infarctionPrognostic accuracyCardiac eventsTIMI scoreLow-risk thresholdSystematic reviewPrediction of MIMyocardial Infarction (TIMI) scoreAdult ED patientsChest pain patientsShort-term incidenceClinical decision instrumentWeb of ScienceAdult patientsPain patientsED patientsRisk stratificationCochrane DatabasePatient populationCoronary Computed Tomography Angiography Versus Stress Echocardiography in Acute Chest Pain A Randomized Controlled Trial
Levsky J, Haramati L, Spevack D, Menegus M, Chen T, Mizrachi S, Brown-Manhertz D, Selesny S, Lerer R, White D, Tobin J, Taub C, Garcia M. Coronary Computed Tomography Angiography Versus Stress Echocardiography in Acute Chest Pain A Randomized Controlled Trial. JACC Cardiovascular Imaging 2018, 11: 1288-1297. PMID: 29909113, DOI: 10.1016/j.jcmg.2018.03.024.Peer-Reviewed Original ResearchMeSH KeywordsAdultAngina PectorisClinical Decision-MakingComparative Effectiveness ResearchComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseEchocardiography, StressEmergency Service, HospitalFemaleHumansLength of StayMaleMiddle AgedMultidetector Computed TomographyPatient AdmissionPatient SelectionPredictive Value of TestsRadiation DosageRadiation ExposureTreatment OutcomeTriageConceptsCoronary CTACardiovascular eventsHospital lengthAcute chest pain patientsMajor adverse cardiovascular eventsRadiation exposureMedian hospital lengthAdverse cardiovascular eventsMedian ED lengthChest pain patientsCoronary artery diseaseEmergency department useSerum troponin levelsChest pain triageCTA patientsPrimary endpointSafety endpointSecondary endpointsPatient ageTroponin levelsArtery diseaseED lengthPain patientsSE patientsStress echocardiographyPrevalence and characteristics of coronary microvascular dysfunction among chest pain patients in the emergency department
Safdar B, D’Onofrio G, Dziura J, Russell RR, Johnson C, Sinusas AJ. Prevalence and characteristics of coronary microvascular dysfunction among chest pain patients in the emergency department. European Heart Journal Acute Cardiovascular Care 2018, 9: 5-13. PMID: 29543037, DOI: 10.1177/2048872618764418.Peer-Reviewed Original ResearchConceptsCoronary microvascular dysfunctionCoronary artery diseaseCardiac positron emission tomography/Positron emission tomography/Chest pain patientsArtery diseaseAcute myocardial infarctionEmission tomography/Chest painMyocardial infarctionMicrovascular dysfunctionPain patientsEmergency departmentTomography/General emergency department populationLower coronary flow reserveNon-obstructive coronary arteriesPrior emergency department visitsTraditional cardiac risk factorsCardiac risk factorsModerate-risk patientsEmergency department visitsEmergency department patientsCoronary flow reserveEmergency department population
2016
MICROVASCULAR ANGINA IN THE ABSENCE OF CORONARY ARTERY DISEASE IS COMMON IN UNDIFFERENTIATED CHEST PAIN PATIENTS IN THE EMERGENCY DEPARTMENT
Safdar B, D’Onofrio G, Dziura J, Russell R, Naftilan M, Johnson C, Sinusas A. MICROVASCULAR ANGINA IN THE ABSENCE OF CORONARY ARTERY DISEASE IS COMMON IN UNDIFFERENTIATED CHEST PAIN PATIENTS IN THE EMERGENCY DEPARTMENT. Journal Of The American College Of Cardiology 2016, 67: 1824. DOI: 10.1016/s0735-1097(16)31825-3.Peer-Reviewed Original Research
2014
Effectiveness of the Chest Pain Choice decision aid in emergency department patients with low-risk chest pain: study protocol for a multicenter randomized trial
Anderson RT, Montori VM, Shah ND, Ting HH, Pencille LJ, Demers M, Kline JA, Diercks DB, Hollander JE, Torres CA, Schaffer JT, Herrin J, Branda M, Leblanc A, Hess EP. Effectiveness of the Chest Pain Choice decision aid in emergency department patients with low-risk chest pain: study protocol for a multicenter randomized trial. Trials 2014, 15: 166. PMID: 24884807, PMCID: PMC4031497, DOI: 10.1186/1745-6215-15-166.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAngina, UnstableCardiology Service, HospitalClinical ProtocolsCommunicationConflict, PsychologicalDecision Support TechniquesEmergency Service, HospitalHealth Knowledge, Attitudes, PracticeHealth ResourcesHumansMyocardial InfarctionPatient Education as TopicPhysician-Patient RelationsPredictive Value of TestsPrognosisResearch DesignRisk AssessmentRisk FactorsSurveys and QuestionnairesTime FactorsUnited StatesVideo RecordingConceptsAdvanced cardiac testingAcute coronary syndromeDiverse emergency departmentsEmergency departmentCardiac testingHealthcare utilizationLow-risk chest pain patientsLow-risk chest painMajor adverse cardiac eventsMethods/designThisAdverse cardiac eventsLow-risk patientsProportion of patientsChest pain patientsCommon reason patientsEmergency department patientsPatient-clinician discussionsHospital billing recordsPatient-centered outcomesElectronic medical recordsAvailable management optionsDecision aidChest painCoronary syndromeUsual care
2013
Rationale and Design of a Randomized Trial Comparing Initial Stress Echocardiography versus Coronary CT Angiography in Low‐to‐Intermediate Risk Emergency Department Patients with Chest Pain
Levsky J, Haramati L, Taub C, Spevack D, Menegus M, Travin M, Vega S, Lerer R, Brown‐Manhertz D, Hirschhorn E, Tobin J, Garcia M. Rationale and Design of a Randomized Trial Comparing Initial Stress Echocardiography versus Coronary CT Angiography in Low‐to‐Intermediate Risk Emergency Department Patients with Chest Pain. Echocardiography 2013, 31: 744-750. PMID: 24372760, DOI: 10.1111/echo.12464.Peer-Reviewed Original ResearchMeSH KeywordsAdultAged, 80 and overCausalityChest PainComorbidityCoronary AngiographyCoronary Artery DiseaseEchocardiographyEmergency Service, HospitalExercise TestFemaleHealth Care CostsHospitalizationHumansIncidenceMaleMiddle AgedNew YorkResearch DesignRisk AssessmentTomography, X-Ray ComputedYoung AdultConceptsTreadmill stress echocardiographyStress echocardiographyEmergency departmentComparative effectiveness researchChest painED chest pain patientsMajor adverse cardiovascular eventsRisk Emergency Department PatientsSignificant coronary artery diseaseED/hospitalAcute chest painAdverse cardiovascular eventsIncidence of hospitalizationChest pain patientsCoronary artery diseaseEmergency department patientsImaging modalitiesLength of stayCoronary CT angiographyDecrease healthcare expendituresNoninvasive diagnostic algorithmCost of careNoninvasive imaging modalityCardiovascular eventsObservational registry
2009
Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging
Senior R, Monaghan M, Main M, Zamorano J, Tiemann K, Agati L, Weissman N, Klein A, Marwick T, Ahmad M, DeMaria A, Zabalgoitia M, Becher H, Kaul S, Udelson J, Wackers F, Walovitch R, Picard M. Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging. European Heart Journal - Cardiovascular Imaging 2009, 10: 26-35. PMID: 19131498, DOI: 10.1093/ejechocard/jen321.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overArea Under CurveContrast MediaCoronary Artery DiseaseDipyridamoleEchocardiography, StressFemaleFluorocarbonsGated Blood-Pool ImagingHumansImage EnhancementImage Interpretation, Computer-AssistedInternational CooperationMaleMiddle AgedObserver VariationROC CurveSensitivity and SpecificityStatistics, NonparametricTomography, Emission-Computed, Single-PhotonYoung AdultConceptsChest pain patientsPain patientsStress echocardiographyPerfusion imagingNon-inferior sensitivityPhase 3 trialCoronary artery diseaseCoronary artery disease detectionQuantitative coronary angiographyNon-inferiority analysisRadionuclide perfusion imagingSingle photon emissionAdverse eventsArtery diseaseCoronary angiographyBlinded cardiologistsClinical reviewDipyridamole stressMyocardial perfusionSPECT perfusionInternational trialRAMP 1Diagnostic performanceSPECTCharacteristic curve
2007
153: The Cost of Unnecessary Cardiac Catheterization: Creating a Case for Better Evaluation of Low Risk Chest Pain Patients
Venkatesh A, Khare R, Powell E, Courtney D. 153: The Cost of Unnecessary Cardiac Catheterization: Creating a Case for Better Evaluation of Low Risk Chest Pain Patients. Annals Of Emergency Medicine 2007, 50: s49. DOI: 10.1016/j.annemergmed.2007.06.186.Peer-Reviewed Original Research
2001
Selective use of single-photon emission computed tomography myocardial perfusion imaging in a chest pain center
Abbott B, Abdel-Aziz I, Nagula S, Monico E, Schriver J, Wackers F. Selective use of single-photon emission computed tomography myocardial perfusion imaging in a chest pain center. The American Journal Of Cardiology 2001, 87: 1351-1355. PMID: 11397352, DOI: 10.1016/s0002-9149(01)01551-x.Peer-Reviewed Original ResearchConceptsChest pain centerChest pain patientsCoronary artery diseasePain patientsSingle photon emissionChest painPain centerArtery diseaseMyocardial infarctionEmergency department chest pain centersEmergency department chest pain patientsTomography myocardial perfusion imagingTomography myocardial perfusionAcute myocardial infarctionMyocardial perfusion imagingSelective useCPC patientsNonischemic electrocardiogramHospital dischargeAppropriate patientsHospital admissionFinal diagnosisMyocardial perfusionPatientsPerfusion imagingCan Practice Guidelines Be Transported Effectively to Different Settings? Results from a Multicenter Interventional Study
Lichtman J, Roumanis S, Radford M, Riedinger M, Weingarten S, Krumholz H. Can Practice Guidelines Be Transported Effectively to Different Settings? Results from a Multicenter Interventional Study. The Joint Commission Journal On Quality And Patient Safety 2001, 27: 42-53. PMID: 11147239, DOI: 10.1016/s1070-3241(01)27005-9.Peer-Reviewed Original ResearchMeSH KeywordsAgedChest PainConnecticutFollow-Up StudiesHealth Care SurveysHospitalizationHumansInterviews as TopicMaleMiddle AgedNebraskaNorth CarolinaOutcome Assessment, Health CarePatient DischargePatient SatisfactionPennsylvaniaPractice Guidelines as TopicProspective StudiesSouth CarolinaSurveys and QuestionnairesConceptsChest painClinical guidelinesIntervention periodGuideline adherenceGuideline implementationPatient outcomesLow-risk chest pain patientsLow-risk chest painStandardized protocolMulticenter interventional studyLow-risk patientsChest pain patientsInterventional trialsPain patientsSuccessful translationClinical outcomesGuideline periodInterventional studyPatient satisfactionPatient's physicianPractice guidelinesHospital settingBaseline valuesClinical practicePain
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