2022
Oridonin ameliorates acetaminophen‐induced acute liver injury through ATF4/PGC‐1α pathway
Yu D, Li J, Wang Y, Guo D, Zhang X, Chen M, Zhou Z. Oridonin ameliorates acetaminophen‐induced acute liver injury through ATF4/PGC‐1α pathway. Drug Development Research 2022, 84: 211-225. PMID: 36567664, DOI: 10.1002/ddr.22024.Peer-Reviewed Original ResearchConceptsAcute liver injuryPGC-1α pathwayLiver injuryCytochrome P450 2E1 (CYP2E1) levelsEndoplasmic reticulum stress activationOxidative stressP450 2E1 levelsImproved liver functionPotential therapeutic effectsPGC-1α levelsHepatocyte cell deathUnclear molecular mechanismsLiver functionProinflammatory cytokinesHepatic toxicityHepatoprotective effectTherapeutic effectAPAP metabolismATF4 knockdownNecrotic areasWestern blotAPAPMetabolic activationMitochondrial dysfunctionProtein levels
2020
Pediatric unilobar resection in primary ciliary dyskinesia.
Sendon C, Cowles R, Worhunsky D, Hodson D, Morotti R, Bazzy-Asaad A, Esquibies A. Pediatric unilobar resection in primary ciliary dyskinesia. Minerva Pediatrica 2020, 74: 593-599. PMID: 32731729, DOI: 10.23736/s2724-5276.20.05802-8.Peer-Reviewed Original ResearchConceptsPrimary ciliary dyskinesiaSevere lung diseasePulmonary functionLung diseaseCiliary dyskinesiaAggressive medical managementSelective surgical removalQuality of lifeProgressive bronchiectasisUnilobar diseaseProphylactic antibioticsLung resectionAggressive administrationAirway clearanceMedical managementChronic bronchiectasisTherapy optionsLocalized bronchiectasisSurgical removalChronic infectionBronchiectasisRare caseAlternative treatmentNutritional statusNecrotic areasAnticholestatic Effect of Bardoxolone Methyl on Hepatic Ischemia-reperfusion Injury in Rats
Kim J, Hagen C, Kumar S, Park J, Zimmerman M, Hong J. Anticholestatic Effect of Bardoxolone Methyl on Hepatic Ischemia-reperfusion Injury in Rats. Transplantation Direct 2020, 6: e584. PMID: 32766432, PMCID: PMC7371100, DOI: 10.1097/txd.0000000000001017.Peer-Reviewed Original ResearchHepatic ischemia-reperfusion injuryHepatocyte membrane transportersIschemia-reperfusion injuryMultidrug resistance-associated protein 3Multidrug resistance-associated protein 2Bardoxolone methyl administrationSodium-taurocholate cotransporterBardoxolone methylProtein 3Bile salt export pumpProtein 2Serum bile acidsNuclear factor-erythroid 2-related factor 2 activationNuclear factor erythroid 2-related factor 2Factor erythroid 2-related factor 2Erythroid 2-related factor 2Sham surgerySurrogate markerExport pumpAnticholestatic effectsBlood samplesMRNA levelsViable tissueNecrotic areasProtein levels
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