2024
Autocatalytic, Brain Tumor‐Targeting Delivery of Bardoxolone Methyl Self‐Assembled Nanoparticles for Glioblastoma Treatment
Ye Z, Sheu W, Qu H, Peng B, Liu J, Zhang L, Yuan F, Wei Y, Zhou J, Chen Q, Xiao X, Zhang S. Autocatalytic, Brain Tumor‐Targeting Delivery of Bardoxolone Methyl Self‐Assembled Nanoparticles for Glioblastoma Treatment. Small Science 2024, 4 DOI: 10.1002/smsc.202470027.Peer-Reviewed Original ResearchAutocatalytic, Brain Tumor‐Targeting Delivery of Bardoxolone Methyl Self‐Assembled Nanoparticles for Glioblastoma Treatment
Ye Z, Sheu W, Qu H, Peng B, Liu J, Zhang L, Yuan F, Wei Y, Zhou J, Chen Q, Xiao X, Zhang S. Autocatalytic, Brain Tumor‐Targeting Delivery of Bardoxolone Methyl Self‐Assembled Nanoparticles for Glioblastoma Treatment. Small Science 2024, 4: 2400081. PMID: 40212541, PMCID: PMC11935168, DOI: 10.1002/smsc.202400081.Peer-Reviewed Original ResearchBlood-brain barrierBardoxolone methylGlioblastoma multiformeBrain tumorsSurvival of miceSelf-assembled nanoparticlesInhibited GBM tumor growthEnhance drug penetrationGlioblastoma multiforme treatmentKill GBM cellsLack of effective drugsTumor growthDrug penetrationIntravenous administrationP28 peptideEffective drugsGlioblastoma treatmentTumorClinical applicationGBM cellsPeptide-conjugatesTreatmentBrainBardoxoloneGlioblastoma
2020
Anticholestatic Effect of Bardoxolone Methyl on Hepatic Ischemia-reperfusion Injury in Rats
Kim J, Hagen C, Kumar S, Park J, Zimmerman M, Hong J. Anticholestatic Effect of Bardoxolone Methyl on Hepatic Ischemia-reperfusion Injury in Rats. Transplantation Direct 2020, 6: e584. PMID: 32766432, PMCID: PMC7371100, DOI: 10.1097/txd.0000000000001017.Peer-Reviewed Original ResearchHepatic ischemia-reperfusion injuryHepatocyte membrane transportersIschemia-reperfusion injuryMultidrug resistance-associated protein 3Multidrug resistance-associated protein 2Bardoxolone methyl administrationSodium-taurocholate cotransporterBardoxolone methylProtein 3Bile salt export pumpProtein 2Serum bile acidsNuclear factor-erythroid 2-related factor 2 activationNuclear factor erythroid 2-related factor 2Factor erythroid 2-related factor 2Erythroid 2-related factor 2Sham surgerySurrogate markerExport pumpAnticholestatic effectsBlood samplesMRNA levelsViable tissueNecrotic areasProtein levels
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