Anticholestatic Effect of Bardoxolone Methyl on Hepatic Ischemia-reperfusion Injury in Rats
Kim J, Hagen C, Kumar S, Park J, Zimmerman M, Hong J. Anticholestatic Effect of Bardoxolone Methyl on Hepatic Ischemia-reperfusion Injury in Rats. Transplantation Direct 2020, 6: e584. PMID: 32766432, PMCID: PMC7371100, DOI: 10.1097/txd.0000000000001017.Peer-Reviewed Original ResearchHepatic ischemia-reperfusion injuryHepatocyte membrane transportersIschemia-reperfusion injuryMultidrug resistance-associated protein 3Multidrug resistance-associated protein 2Bardoxolone methyl administrationSodium-taurocholate cotransporterBardoxolone methylProtein 3Bile salt export pumpProtein 2Serum bile acidsNuclear factor-erythroid 2-related factor 2 activationNuclear factor erythroid 2-related factor 2Factor erythroid 2-related factor 2Erythroid 2-related factor 2Sham surgerySurrogate markerExport pumpAnticholestatic effectsBlood samplesMRNA levelsViable tissueNecrotic areasProtein levels
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