2022
circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment
Piras R, Ko E, Barrett C, De Simone M, Lin X, Broz M, Tessaro F, Castillo-Martin M, Cordon-Cardo C, Goodridge H, Di Vizio D, Batish M, Lawrenson K, Chen Y, Chan K, Guarnerio J. circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment. Nature Communications 2022, 13: 7243. PMID: 36433954, PMCID: PMC9700836, DOI: 10.1038/s41467-022-34872-8.Peer-Reviewed Original ResearchConceptsNon-coding RNA speciesExonic circular RNAsViral RNA sensorsRNA speciesInterferon-related genesSpecific circRNAsCircular RNAsSarcoma cellsCircRNAsRNA sensorsCancer progressionFunctional contributionInterferon responseSoft tissue sarcoma cellsImmune cell recruitmentPro-tumorigenic microenvironmentCellsTumor growthSarcoma growthTumor cellsPro-inflammatory elementsCell recruitmentActivationPro-inflammatory factorsMicroenvironment
2020
Depletion of CD4 T cells provides therapeutic benefits in aged mice after ischemic stroke
Harris NM, Roy-O'Reilly M, Ritzel RM, Holmes A, Sansing LH, O'Keefe LM, McCullough LD, Chauhan A. Depletion of CD4 T cells provides therapeutic benefits in aged mice after ischemic stroke. Experimental Neurology 2020, 326: 113202. PMID: 31954116, PMCID: PMC7059209, DOI: 10.1016/j.expneurol.2020.113202.Peer-Reviewed Original ResearchConceptsIP-10 levelsMiddle cerebral artery occlusionCD4 T cellsT cellsIschemic strokeStroke patientsIsotype controlBrain-infiltrating T cellsCD4 T-cell depletionCerebral artery occlusionT-cell depletionAged mouse modelAged male micePro-inflammatory factorsT cell dysfunctionPro-inflammatory cytokinesAnti-CD4 antibodiesAged stroke patientsIgG isotype controlCD4 treatmentDepletion antibodyArtery occlusionExperimental strokeStroke onsetSham surgery
2019
SHIP‐1, a target of miR‐155, regulates endothelial cell responses in lung fibrosis
Tang H, Mao J, Ye X, Zhang F, Kerr W, Zheng T, Zhu Z. SHIP‐1, a target of miR‐155, regulates endothelial cell responses in lung fibrosis. The FASEB Journal 2019, 34: 2011-2023. PMID: 31907997, PMCID: PMC7449602, DOI: 10.1096/fj.201902063r.Peer-Reviewed Original ResearchConceptsMouse lung endothelial cellsLung fibrosisFibrotic responseHuman umbilical vein endothelial cellsMiR-155Endothelial cellsKnockout miceMiR-155 knockout micePrimary mouse lung endothelial cellsMiR-155KO miceSHIP-1Spontaneous lung inflammationPro-inflammatory factorsLung fibrosis modelEndothelial-mesenchymal transitionLung endothelial cellsUmbilical vein endothelial cellsPI3K/AktTGF-β1 stimulationJAK/STAT3Lung inflammationVein endothelial cellsInositol phosphatase-1BLM challengeFibrosis model
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