2024
D239Y germline variant of NTHL1 glycosylase increases susceptibility to colorectal cancer in mice
Masannat T, Ghishan F, Kiela P, Sweasy J. D239Y germline variant of NTHL1 glycosylase increases susceptibility to colorectal cancer in mice. Physiology 2024, 39: 2118. DOI: 10.1152/physiol.2024.39.s1.2118.Peer-Reviewed Original ResearchInflammation-associated colorectal cancerColorectal cancerDistal colonColon lengthSusceptibility to colorectal cancerC57BL/6 wild-typeMicronucleated normochromatic erythrocytesProximal tumor locationFemale C57BL/6 wild-typeIncreased lifetime riskDextran sulfate sodiumSize of polypsMonitoring body weightKnock-In MiceIncreased polyp numberDominant-negative mutationsNormal drinking waterDSS cycleTumor locationWT miceNormochromatic erythrocytesDNA damageWT littermatesColitis scoresRepair mechanisms
2019
830 Can CD74 Predict Treatment Response to Anti-TNF Agents in Inflammatory Bowel Disease?
Farr L, Bucala R, Moonah S. 830 Can CD74 Predict Treatment Response to Anti-TNF Agents in Inflammatory Bowel Disease? The American Journal Of Gastroenterology 2019, 114: s480-s480. DOI: 10.14309/01.ajg.0000592856.82828.b1.Peer-Reviewed Original ResearchCD74 deficient miceAnti-TNF failureAnti-TNF agentsDeficient miceIBD patientsInflammatory bowel disease therapyNormal wild-type miceSevere intestinal damageAnti-TNF drugsAnti-TNF therapyAnti-TNF treatmentManagement of IBDColitis mouse modelInflammatory bowel diseaseBody weight lossNormal drinking waterWild-type micePersonalized medicine approachEpithelial layer integrityTight junction markersColon shorteningDSS administrationMucosal healingMyeloperoxidase levelsBowel disease
2006
Chronic angiotensin-(1–7) prevents cardiac fibrosis in DOCA-salt model of hypertension
Grobe JL, Mecca AP, Mao H, Katovich MJ. Chronic angiotensin-(1–7) prevents cardiac fibrosis in DOCA-salt model of hypertension. AJP Heart And Circulatory Physiology 2006, 290: h2417-h2423. PMID: 16415071, DOI: 10.1152/ajpheart.01170.2005.Peer-Reviewed Original ResearchConceptsDOCA-salt modelBlood pressureCardiac hypertrophyCardiac fibrosisCardiac remodelingDeoxycorticosterone acetate pelletsDOCA-salt animalsBlood pressure responseCarotid artery cannulationDOCA-salt treatmentTail-cuff methodWk of treatmentPerivascular collagen depositionSprague-Dawley ratsNormal drinking waterAngiotensin fragmentsChronic angiotensinDOCA animalsAngiotensin infusionArtery cannulationPerivascular fibrosisSham surgeryAngiotensin IIOsmotic minipumpsMyocyte diameter
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