2025
Weight Loss Is Protective in Preclinical Breast Cancer Models: Interactions with the Anticancer Immune Response.
Sassoon R, Perry R. Weight Loss Is Protective in Preclinical Breast Cancer Models: Interactions with the Anticancer Immune Response. Cancer Prevention Research 2025, of1-of2. PMID: 40421602, DOI: 10.1158/1940-6207.capr-25-0168.Peer-Reviewed Original ResearchICR miceIntermittent calorie restrictionE0771 breast cancer cellsPreclinical breast cancer modelsRate of tumor growthTriple-negative breast cancerAnticancer immune responseBreast cancer modelBreast cancer cellsCancer prevention researchAntitumor immunityHigh-fat dietTumor sizeImmune dysfunctionPreclinical evidenceLean controlsPoor prognosisCancer modelsBreast cancerTumor growthOld miceObesogenic dietAdvanced ageIncreased riskImmune response
2023
Prenatal Choline Supplement in a Maternal Obesity Model Modulates Offspring Hepatic Lipidomes
Korsmo H, Kadam I, Reaz A, Bretter R, Saxena A, Johnson C, Caviglia J, Jiang X. Prenatal Choline Supplement in a Maternal Obesity Model Modulates Offspring Hepatic Lipidomes. Nutrients 2023, 15: 965. PMID: 36839327, PMCID: PMC9963284, DOI: 10.3390/nu15040965.Peer-Reviewed Original ResearchConceptsMetabolic-associated fatty liver diseaseMaternal choline supplementationHF feedingHepatic lipidomeCholine supplementationMale offspringFatty liver diseaseChronic metabolic diseaseSemi-essential nutrientsNervonic acidEmbryonic day 17.5MAFLD progressionMaternal obesityLiver diseaseInsulin resistanceMouse offspringObesogenic dietOffspring liverLipid overloadOffspring healthLower oxidative stressMetabolic diseasesCholine supplementsMacronutrient metabolismDay 17.5
2018
Technical Feasibility of a Murine Model of Sleeve Gastrectomy with Ileal Transposition
Ying LD, Breuer GA, Hubbard MO, Nadzam GS, Hwa J, Martin KA. Technical Feasibility of a Murine Model of Sleeve Gastrectomy with Ileal Transposition. Obesity Surgery 2018, 29: 593-600. PMID: 30353248, PMCID: PMC6365182, DOI: 10.1007/s11695-018-3555-7.Peer-Reviewed Original ResearchConceptsIleal transpositionSleeve gastrectomySham surgeryMouse modelReproducible mouse modelIntestinal identityQuantitative polymerase chain reactionBackgroundSleeve gastrectomySham procedureC57BL/6J miceObesogenic dietPolymerase chain reactionGastrectomyMurine modelPorcine modelWeight gainWeight lossMiceChain reactionMolecular pathwaysGene expression analysisWeeksFuture studiesLong-term survivabilityTechnical feasibility
2016
A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer
Asgharpour A, Cazanave SC, Pacana T, Seneshaw M, Vincent R, Banini BA, Kumar DP, Daita K, Min HK, Mirshahi F, Bedossa P, Sun X, Hoshida Y, Koduru SV, Contaifer D, Warncke UO, Wijesinghe DS, Sanyal AJ. A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer. Journal Of Hepatology 2016, 65: 579-588. PMID: 27261415, PMCID: PMC5012902, DOI: 10.1016/j.jhep.2016.05.005.Peer-Reviewed Original ResearchConceptsNon-alcoholic steatohepatitisNon-alcoholic fatty liver diseaseDiet-induced animal modelsProgressive non-alcoholic steatohepatitisHuman non-alcoholic steatohepatitisFatty liver diseaseHepatocellular cancerLiver diseaseAnimal modelsDiet-induced mouse modelGene signatureHigh-fat dietSimilar histological phenotypesAd libitum consumptionProgressive fibrosisLDL cholesterolChow dietMice fedInsulin resistanceFat dietClinical endpointsHuman NAFLDObesogenic dietPreclinical modelsMouse model
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