2019
Effects of Hormone Therapy on Heart Fat and Coronary Artery Calcification Progression: Secondary Analysis From the KEEPS Trial
Khoudary S, Zhao Q, Venugopal V, Manson JE, Brooks MM, Santoro N, Black DM, Harman SM, Cedars MI, Hopkins PN, Kearns AE, Miller VM, Taylor HS, Budoff MJ. Effects of Hormone Therapy on Heart Fat and Coronary Artery Calcification Progression: Secondary Analysis From the KEEPS Trial. Journal Of The American Heart Association 2019, 8: e012763. PMID: 31652073, PMCID: PMC6761637, DOI: 10.1161/jaha.119.012763.Peer-Reviewed Original ResearchConceptsOral conjugated equine estrogenConjugated equine estrogensCoronary artery calcification (CAC) progressionBaseline CAC scoreEpicardial adipose tissueCAC scoreEquine estrogensMenopausal womenCAC progressionCalcification progressionAdipose tissueEpicardial adipose tissue accumulationEarly menopausal womenPlacebo-controlled trialAdipose tissue accumulationHormone therapy formulationsProgression of CACKEEP participantsHormone therapySubclinical atherosclerosisCAC measuresEndogenous estrogensFat accumulationTreatment groupsFat depots
2014
Endogenous and exogenous hormone exposure and the risk of meningioma in men.
Schildkraut JM, Calvocoressi L, Wang F, Wrensch M, Bondy ML, Wiemels JL, Claus EB. Endogenous and exogenous hormone exposure and the risk of meningioma in men. Journal Of Neurosurgery 2014, 120: 820-6. PMID: 24484233, PMCID: PMC4386752, DOI: 10.3171/2013.12.jns131170.Peer-Reviewed Original ResearchConceptsBody mass indexMeningioma riskOdds ratioHigher Body Mass IndexExogenous hormone exposureMultivariate logistic regressionRelated risk factorsConfidence intervalsRisk of meningiomaPrevalence of exposureConsiderable morbidityMale patientsMass indexRisk factorsEndogenous estrogensReduced riskHormonal factorsHormone exposureIntracranial meningiomasExogenous exposureMeningiomasLogistic regressionUse of soyMenRisk
2006
Effects of estradiol and medroxyprogesterone acetate on flow mediated dilation in young women
Meendering J, Torgrimson B, Kaplan P, Stachenfeld N, Minson C. Effects of estradiol and medroxyprogesterone acetate on flow mediated dilation in young women. The FASEB Journal 2006, 20: a301-a301. DOI: 10.1096/fasebj.20.4.a301-c.Peer-Reviewed Original ResearchMedroxyprogesterone acetateDay 5Day 10Gonadotropin-releasing hormone antagonistBaseline brachial artery diameterYoung womenEndothelial-dependent vasodilationBrachial artery diameterPreliminary dataMedical Research FoundationIndependent vasodilationDependent vasodilationBrachial arteryNitroglycerin administrationGnRHa administrationMPA administrationArtery diameterHormone antagonistEndogenous estrogensGnRHaVessel responsivenessDay 4Hormone treatmentAcute affectsE2
2003
Effects of estrogen and progesterone administration on extracellular fluid
Stachenfeld NS, Taylor HS. Effects of estrogen and progesterone administration on extracellular fluid. Journal Of Applied Physiology 2003, 96: 1011-1018. PMID: 14660504, DOI: 10.1152/japplphysiol.01032.2003.Peer-Reviewed Original ResearchConceptsGnRH antagonist administrationExtracellular fluid volumeGnRH antagonistEffects of estrogenAntagonist administrationPlasma volumeTranscapillary escape rateGonadotropin-releasing hormoneExtracellular fluidHealthy womenProgesterone administrationECFV expansionGanirelix acetateEndogenous estrogensStrong negative predictorDay 2Day 5Pg/AntagonistEstrogenDay 12Plasma compartmentCapillary endotheliumAdministrationProgesterone
2002
Estrogen effects on osmotic regulation of AVP and fluid balance
Stachenfeld NS, Keefe DL. Estrogen effects on osmotic regulation of AVP and fluid balance. AJP Endocrinology And Metabolism 2002, 283: e711-e721. PMID: 12217888, DOI: 10.1152/ajpendo.00192.2002.Peer-Reviewed Original ResearchConceptsHormone treatmentEstrogen effectsPlasma renin activityFree water clearanceEnd of recoveryIntrarenal effectsRenal sensitivityRenin activitySodium excretionFractional excretionAVP increaseSodium retentionFluid retentionLeuprolide acetateWater clearanceEndogenous estrogensAldosterone stimulationFluid balanceGnRHaNaCl infusionPg/EstrogenAVPProgesteroneExcretion
1997
Estrogen Replacement Therapy: New Options, Continuing Concerns-Reply
Insogna K, Concato J, Henrich J. Estrogen Replacement Therapy: New Options, Continuing Concerns-Reply. JAMA 1997, 277: 1516-1517. DOI: 10.1001/jama.1997.03540430028020.Peer-Reviewed Original ResearchBreast cancer riskBreast cancerBone densityCancer riskLow endogenous estrogen levelsHigh endogenous estrogenEstrogen replacement therapyEndogenous estrogen levelsTreatment of osteoporosisHigher bone densityAfrican American womenEstrogen levelsReplacement therapyExogenous estrogenEstrogen influenceEndogenous estrogensLower riskCancerWomenOsteoporosisRiskEstrogenNew optionsTherapyBMDLack of Gonadotropin-Positive Feedback in the Male Rat Is Associated with Lack of Estrogen-Induced Synaptic Plasticity in the Arcuate Nucleus
Horvath T, Garcia-Segura L, Naftolin F. Lack of Gonadotropin-Positive Feedback in the Male Rat Is Associated with Lack of Estrogen-Induced Synaptic Plasticity in the Arcuate Nucleus. Neuroendocrinology 1997, 65: 136-140. PMID: 9067991, DOI: 10.1159/000127173.Peer-Reviewed Original ResearchConceptsArcuate nucleusFemale ratsSynaptic plasticitySynaptic retractionMale ratsSynapse countsEstrogen-induced synaptic plasticityFemale arcuate nucleusVehicle-injected groupHypothalamic arcuate nucleusAdministration of estrogenAfternoon of proestrusQuantitative electron microscopic analysisOil-injected controlsGonadotropin secretionSynaptic reorganizationSynaptic countsConstant estrusEndogenous estrogensSynaptic remodelingSingle injectionTreatment groupsHormone injectionEstrogenOvarian cycle
1996
Tubal sterilization and the risk of endometrial cancer
Castellsagué X, Thompson W, Dubrow R. Tubal sterilization and the risk of endometrial cancer. International Journal Of Cancer 1996, 65: 607-612. PMID: 8598311, DOI: 10.1002/(sici)1097-0215(19960301)65:5<607::aid-ijc9>3.0.co;2-6.Peer-Reviewed Original ResearchConceptsEpithelial endometrial cancerEndometrial cancerTubal sterilizationProtective effectMulticenter population-based case-control studyPopulation-based case-control studyNon-significant protective effectPopulation-based cancer registriesCase-control studyCrude odds ratiosEpithelial endometrial carcinomaYears of ageMethod of contraceptionCancer RegistryEndometrial carcinomaOvarian functionTubal occlusionWomen 20Odds ratioEndogenous estrogensProtective associationEndometrial carcinogenesisWoman's riskHuman studiesCancer
1994
Increasing Hypothalamic Arcuate Nucleus Glial Peroxidase Activity in Aging Female Rats Is Reduced by an Antiestrogen and a Gonadotropin-Releasing Hormone Agonist
Seifer D, Roa-Peña L, Keefe D, Zhang H, Goodman S, Jones E, Naftolin F. Increasing Hypothalamic Arcuate Nucleus Glial Peroxidase Activity in Aging Female Rats Is Reduced by an Antiestrogen and a Gonadotropin-Releasing Hormone Agonist. Menopause The Journal Of The North American Menopause Society 1994, 1: 83-90. DOI: 10.1097/00042192-199400120-00005.Peer-Reviewed Original ResearchMonths of ageFemale ratsGoserelin acetate depotPosterior periventricular areasComputerized image analyzerAge-related increaseDiaminobenzidine tetrahydrochloridePeriventricular areaArcuate nucleusGoserelin acetateEndogenous estrogensHypothalamic sectionsControl groupSuper agonistReproductive agingMonthsRatsPeroxidase activityDAB reactionAgeGroupImplantsAnimalsImage analyzerSerial sectioning
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