2024
Reading the palimpsest of cell interactions: What questions may we ask of the data?
Pavlicev M, Wagner G. Reading the palimpsest of cell interactions: What questions may we ask of the data? IScience 2024, 27: 109670. PMID: 38665209, PMCID: PMC11043885, DOI: 10.1016/j.isci.2024.109670.Peer-Reviewed Original ResearchCompartmentalization of cellular processesStructure of interaction networksCell interactionsMulticellular organismsIntegrity of cellsCellular processesInteraction networkLevels of structural organizationBiological functionsBiological interpretationCell communicationInteraction dataStructural organizationWealth of dataCellsCoordination of functionsOrganizationHigher levels of structural organizationCompartmentalizationInteractionHomotopic functional connectivity disruptions in schizophrenia and their associated gene expression
Cai M, Ji Y, Zhao Q, Xue H, Sun Z, Wang H, Zhang Y, Chen Y, Zhao Y, Zhang Y, Lei M, Wang C, Zhuo C, Liu N, Liu H, Liu F. Homotopic functional connectivity disruptions in schizophrenia and their associated gene expression. NeuroImage 2024, 289: 120551. PMID: 38382862, DOI: 10.1016/j.neuroimage.2024.120551.Peer-Reviewed Original ResearchConceptsVoxel-mirrored homotopic connectivityAbnormal VMHCAllen Human Brain AtlasFunctional connectivity disruptionsHuman Brain AtlasExtensive cortical regionsBrain gene expression profilesIllness durationHomotopic connectivitySchizophreniaDecoding analysesCortical regionsConnectivity disruptionsDevelopmental time windowCell communicationChanges compared to controlsExpression of identified genesGene expression dataBrain atlasesRegulation of cell communicationMeta-regression analysisGene expression profilesNervous system developmentExpression dataNeurosynth
2021
Cryo-EM structure of an open conformation of a gap junction hemichannel in lipid bilayer nanodiscs
Khan A, Jagielnicki M, Bennett B, Purdy M, Yeager M. Cryo-EM structure of an open conformation of a gap junction hemichannel in lipid bilayer nanodiscs. Structure 2021, 29: 1040-1047.e3. PMID: 34129834, PMCID: PMC9616683, DOI: 10.1016/j.str.2021.05.010.Peer-Reviewed Original ResearchConceptsLipid bilayer nanodiscsGap junction channelsHexameric hemichannelsExtracellular loopBilayer nanodiscsTransmembrane α-helicesCryo-EM structureGap junction hemichannelsAdjacent cell membranesIntercellular conduitsCell communicationCx hemichannelsPlasma membraneOpen conformationSecond extracellular loopJunction channelsΑ-helixConformational flexibilityCell membraneHemichannelsCx isoformsExtracellular spaceNanodiscsStructural foundationMembrane
2019
Mitofusin 1 is required for female fertility and to maintain ovarian follicular reserve
Zhang M, Bener MB, Jiang Z, Wang T, Esencan E, Scott III R, Horvath T, Seli E. Mitofusin 1 is required for female fertility and to maintain ovarian follicular reserve. Cell Death & Disease 2019, 10: 560. PMID: 31332167, PMCID: PMC6646343, DOI: 10.1038/s41419-019-1799-3.Peer-Reviewed Original ResearchConceptsOocyte-granulosa cell communicationDynamic organellesAccumulation of ceramideFemale reproductive agingMitofusin 1Secondary follicle stageMitochondrial dynamicsCell communicationReproductive phenotypesCeramide synthesis inhibitor myriocinDevelopmental arrestApoptotic cell lossMitochondrial dysfunctionTargeted deletionOvarian follicular reserveOocyte maturationFemale fertilityFollicle stageDeletionPhenotypeReproductive agingOocytesCadherinFollicular reserveOrganelles
2018
Prokaryotic SPHINX 1.8 REP protein is tissue‐specific and expressed in human germline cells
Manuelidis L. Prokaryotic SPHINX 1.8 REP protein is tissue‐specific and expressed in human germline cells. Journal Of Cellular Biochemistry 2018, 120: 6198-6208. PMID: 30317668, DOI: 10.1002/jcb.27907.Peer-Reviewed Original ResearchConceptsOpen reading frameReplication initiation sequencesTissue-specific patternsHuman germline cellsSmall circular DNAREP peptidesGermline cellsMaternal inheritanceRep proteinSomatic cellsReading frameCell communicationEnvironmental infectious agentsMature spermDifferentiation functionPhage virusesCultured cellsCircular DNAInitiation sequenceSymbiotic elementsExocrine cellsFunctional differentiationSpinal cord synapsesMammalian brainDNAThe ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles
Coulter ME, Dorobantu CM, Lodewijk GA, Delalande F, Cianferani S, Ganesh VS, Smith RS, Lim ET, Xu CS, Pang S, Wong ET, Lidov HGW, Calicchio ML, Yang E, Gonzalez DM, Schlaeger TM, Mochida GH, Hess H, Lee WA, Lehtinen MK, Kirchhausen T, Haussler D, Jacobs FMJ, Gaudin R, Walsh CA. The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles. Cell Reports 2018, 24: 973-986.e8. PMID: 30044992, PMCID: PMC6178983, DOI: 10.1016/j.celrep.2018.06.100.Peer-Reviewed Original ResearchConceptsExtracellular vesiclesMultivesicular bodiesIntraluminal vesicle formationESCRT proteinsHedgehog secretionProgenitor maintenanceMolecular mechanistic insightsComplex proteinsCell communicationEV subtypesVesicle formationChmp1AAutosomal recessive microcephalyHuman cerebral organoidsSonic hedgehogProgenitor proliferationFunction mutationsImpairs secretionAdult functionMechanistic insightsCerebral organoidsNull micePontocerebellar hypoplasiaShhProteinCircuit Design Features of a Stable Two-Cell System
Zhou X, Franklin RA, Adler M, Jacox JB, Bailis W, Shyer JA, Flavell RA, Mayo A, Alon U, Medzhitov R. Circuit Design Features of a Stable Two-Cell System. Cell 2018, 172: 744-757.e17. PMID: 29398113, PMCID: PMC7377352, DOI: 10.1016/j.cell.2018.01.015.Peer-Reviewed Original ResearchConceptsMost mammalian tissuesCell-cell contactGrowth factorNegative feedback regulationCell communicationMammalian tissuesCell survivalParacrine signalsFactor exchangeCell typesCell interactionsEnvironmental constraintsExperimental approachTwo-cell systemHomeostasisTissueRegulationCircuit design featuresCell circuitFibroblastsProliferationCellsAnalytical screening
2016
Hardwiring Stem Cell Communication through Tissue Structure
Xin T, Greco V, Myung P. Hardwiring Stem Cell Communication through Tissue Structure. Cell 2016, 164: 1212-1225. PMID: 26967287, PMCID: PMC4805424, DOI: 10.1016/j.cell.2016.02.041.Peer-Reviewed Original Research
2015
Analysis of single-cell cytokine secretion reveals a role for paracrine signaling in coordinating macrophage responses to TLR4 stimulation
Xue Q, Lu Y, Eisele MR, Sulistijo ES, Khan N, Fan R, Miller-Jensen K. Analysis of single-cell cytokine secretion reveals a role for paracrine signaling in coordinating macrophage responses to TLR4 stimulation. Science Signaling 2015, 8: ra59. PMID: 26082435, PMCID: PMC5735825, DOI: 10.1126/scisignal.aaa2155.Peer-Reviewed Original ResearchConceptsGraphical Gaussian modelingMonocyte-derived macrophagesSingle-cell dataMacrophage-like U937 cellsCell populationsHuman monocyte-derived macrophagesRegulatory networksUncharacterized roleCell communicationInnate immune responseParacrine signalsCell heterogeneityCytokine secretionRole of paracrineU937 cellsMultiple cytokinesSingle cellsGGM networkToll-like receptor 4ParacrineSmall subpopulationMacrophage responseCellsRapid innate immune responseCell isolation
2010
Neuroendocrine Properties of the Ciliary Epithelium
Coca-Prados M. Neuroendocrine Properties of the Ciliary Epithelium. 2010, 107-112. DOI: 10.1016/b978-0-12-374203-2.00088-9.Peer-Reviewed Original ResearchCiliary epitheliumAqueous humorOcular hypotensive actionSame embryological originRetinal pigment epitheliumEye aqueous humorOcular ciliary epitheliumHypotensive actionAqueous humor secretionAnterior segmentEndocrine factorsPigment epitheliumNeuroendocrine propertiesEndocrine systemEmbryological originNeuroepithelial cellsEpitheliumAvascular tissueNeuropeptidesBioactive peptidesCellsCell communicationRetinaHormoneSecretion
2007
Advances in renal (patho)physiology using multiphoton microscopy
Sipos A, Toma I, Kang J, Rosivall L, Peti-Peterdi J. Advances in renal (patho)physiology using multiphoton microscopy. Kidney International 2007, 72: 1188-1191. PMID: 17667980, PMCID: PMC2424113, DOI: 10.1038/sj.ki.5002461.Peer-Reviewed Original ResearchConceptsKidney functionJuxtaglomerular apparatusTubuloglomerular feedbackIntrarenal renin-angiotensin systemRenin release mechanismRenin-angiotensin systemMultiphoton microscopyGlomerular filtrationInvasive approachClinical nephrologyVivo experimental approachesOrgan functionDeep optical sectioningTherapeutic toolCytosolic calciumDifferent organsImagingMultiphoton imagingQuantitative imagingExcitation fluorescence microscopyReal-time imagingKidneyNephrologyCell communicationDisease
2006
Adult Neurogenesis: Basic Concepts of Signaling
Bordey A. Adult Neurogenesis: Basic Concepts of Signaling. Cell Cycle 2006, 5: 722-728. PMID: 16582623, DOI: 10.4161/cc.5.7.2614.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAdult neurogenesisMotor memory formationBrain injuryPersistent neurogenesisNeurogenic environmentAdult brainNeurogenic regionsNeuroglial networksNeurogenesisEmbryonic neurogenesisIntegrative propertiesMemory formationExtracellular matrix moleculesCell communicationBrainRecent findingsCellsExamples of cellsMatrix moleculesInjury
2004
Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions
Jensen R, Glazer PM. Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 6134-6139. PMID: 15069205, PMCID: PMC395935, DOI: 10.1073/pnas.0400051101.Peer-Reviewed Original ResearchConceptsDNA-dependent protein kinase (DNA-PK) complexDNA-dependent protein kinase activityDNA-dependent protein kinaseProtein kinase complexProtein kinase activityCell-autonomous mannerGap junctionsBlock transcriptionKinase complexKinase functionProtein kinaseDeath signalsDNA repairCell communicationKinase activityRecipient cellsCellular componentsGap junction expressionHuman cancersNeighboring cellsDirect cellCell killingMechanism of actionCellsJunction expression
2001
Gap Junctional Channels Regulate Acid Secretion in the Mammalian Gastric Gland
Radebold K, Horakova E, Gloeckner J, Ortega G, Spray D, Vieweger H, Siebert K, Manuelidis L, Geibel J. Gap Junctional Channels Regulate Acid Secretion in the Mammalian Gastric Gland. The Journal Of Membrane Biology 2001, 183: 147-153. PMID: 11696856, DOI: 10.1007/s00232-001-0062-9.Peer-Reviewed Original ResearchConceptsGap junction channelsAdjacent parietal cellsCell communicationJunction channelsFunctional gap junction channelsGap junctional channelsPotential physiological roleLucifer yellow transferGap junctional proteinGastric glandsParietal cellsWestern blot analysisJunctional channelsJunctional proteinsPhysiological roleRapid cellBlot analysisCalcium signalsBasolateral membraneCell microinjectionAcid secretory processTransfer of dyeSecretory processIntact glandsCalcium wave propagationChapter 25 Cytokines in Primary Hyperparathyroidism
Nakchbandi I, Grey A, Masiukiewicz U, Mitnick M, Insogna K. Chapter 25 Cytokines in Primary Hyperparathyroidism. 2001, 411-421. DOI: 10.1016/b978-012098651-4/50027-4.ChaptersOsteoclast differentiation factorParathyroid hormonePrimary hyperparathyroidismImmune cell functionColony-stimulating factorResorptive actionSevere inflammationBone resorptionInterleukin-6Resorptive effectsCatabolic cytokinesCytokinesMature osteoclastsPleiotropic actionsImportant mediatorKey mediatorCell functionDifferentiation factorHyperparathyroidismOsteoclastogenesisMediatorsHematopoietic microenvironmentInflammationInfectionCell communication
1986
Concurrent Overproduction of Synapses in Diverse Regions of the Primate Cerebral Cortex
Rakic P, Bourgeois J, Eckenhoff M, Zecevic N, Goldman-Rakic P. Concurrent Overproduction of Synapses in Diverse Regions of the Primate Cerebral Cortex. Science 1986, 232: 232-235. PMID: 3952506, DOI: 10.1126/science.3952506.Peer-Reviewed Original Research
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