2007
Influence of the heme-oxygenase pathway on cerebrocortical blood flow
Leszl-Ishiguro M, Horváth B, Johnson R, Johnson F, Lenzsér G, Hermán P, Horváth E, Benyó Z. Influence of the heme-oxygenase pathway on cerebrocortical blood flow. Neuroreport 2007, 18: 1193-1197. PMID: 17589325, DOI: 10.1097/wnr.0b013e3282202459.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral CortexDeuteroporphyrinsEnzyme ActivationEnzyme InhibitorsHeme Oxygenase (Decyclizing)HypercapniaHypoxiaMaleNG-Nitroarginine Methyl EsterRatsRats, WistarConceptsCerebrocortical blood flowNitric oxide synthaseEndogenous carbon monoxideBlood flowInhibition of NOSDirect vascular effectsHeme oxygenase pathwayCentral nervous systemNOS blockadeVascular effectsCBF responseOxide synthaseAdult ratsNervous systemHeme oxygenaseBlockadeRatsCurrent studyInhibitionHypercapniaLatter effectHypoxiaVEGF‐induced heme oxygenase‐1 confers cytoprotection from lethal hyperoxia in vivo
Siner JM, Jiang G, Cohen ZI, Shan P, Zhang X, Lee CG, Elias JA, Lee PJ. VEGF‐induced heme oxygenase‐1 confers cytoprotection from lethal hyperoxia in vivo. The FASEB Journal 2007, 21: 1422-1432. PMID: 17264168, DOI: 10.1096/fj.06-6661com.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBronchoalveolar Lavage FluidCytoprotectionDisease Models, AnimalDNA PrimersEnzyme InductionHeme Oxygenase (Decyclizing)HumansHyperoxiaIn Situ Nick-End LabelingLipid PeroxidationLungMiceMice, TransgenicRespiratory Distress SyndromeReverse Transcriptase Polymerase Chain ReactionRNA, Small InterferingVascular Endothelial Growth Factor AConceptsHyperoxic acute lung injuryVascular endothelial growth factorAcute lung injuryHeme oxygenase-1Lung injuryTransgenic miceVivo modelLung lavage protein concentrationVEGF transgenic miceLavage protein concentrationEndothelial growth factorHO-1 mRNAHO-1 functionEffect of inhibitionShort hairpin RNAProlong survivalDry ratioProtective effectLethal hyperoxiaHyperoxia resultsOxygenase-1Mouse lungTUNEL stainingCytoprotective effectsInjury
2003
Inhibition of heme oxygenase decreases sodium and fluid absorption in the loop of Henle
Wang T, Sterling H, Shao W, Yan Q, Bailey M, Giebisch G, Wang W. Inhibition of heme oxygenase decreases sodium and fluid absorption in the loop of Henle. American Journal Of Physiology. Renal Physiology 2003, 285: f484-f490. PMID: 12890663, DOI: 10.1152/ajprenal.00135.2003.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptionAnimalsDietDose-Response Relationship, DrugGene ExpressionHeme Oxygenase (Decyclizing)Loop of HenleMaleMesoporphyrinsPotassiumProtoporphyrinsRatsRats, Sprague-DawleySodiumWaterConceptsLoop of HenleHigh K+K+ channelsApical 70-pS K+ channelRegulation of Na+ transportNa+ transportFluid absorptionApical K+ channelsIn vivo microperfusionInhibition of HORenal sodium excretionGlomerular filtration rateHO-2 expressionInhibitor of HORenal clearance studiesHK ratsHO-2K+ recyclingNa+ absorptionUrinary Na+Sodium excretionChromium mesoporphyrinRat chowWestern blot analysisFiltration rateEstrogen, synaptic plasticity and hypothalamic reproductive aging
Hung AJ, Stanbury MG, Shanabrough M, Horvath TL, Garcia-Segura LM, Naftolin F. Estrogen, synaptic plasticity and hypothalamic reproductive aging. Experimental Gerontology 2003, 38: 53-59. PMID: 12543261, DOI: 10.1016/s0531-5565(02)00183-3.Peer-Reviewed Original ResearchConceptsConstant estrusReproductive agingEstrogen exposureMale ratsAnti-oxidant vitamin EEarly estrogen exposureArcuate nucleus neuronsHypothalamic arcuate nucleus neuronsConstant vaginal estrusHypothalamic failureEstradiol exposureGonadotrophin surgeOvarian estrogenArcuate nucleusConstant diestrusNucleus neuronsOvarian failureElevated estradiolPerikaryal membraneFemale ratsPerinatal periodTesticular androgensRat brainSex steroidsHormonal factors
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