Jun He, PhD, MPH
he/him/his
Postdoctoral FellowAbout
Research
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Featured Publications
Age-, sex-, and ancestry-specific prevalence of hearing loss in UK Biobank and All of Us Research Program.
He J, Curhan S, Curhan G, Polimanti R. Age-, sex-, and ancestry-specific prevalence of hearing loss in UK Biobank and All of Us Research Program. Aging And Disease 2025 PMID: 40681351, DOI: 10.14336/ad.2025.0754.Peer-Reviewed Original ResearchUs Research ProgramPrevalence of HLHL prevalenceHearing lossPrevalence of hearing lossUK Biobank (UKBAge-standardized prevalenceIndividuals of diverse ancestral backgroundsElectronic health recordsPolygenic risk scoresAssociated with HLSelf-reported informationDiverse ancestral backgroundsGlobal disease burdenHealth recordsStandard populationUK BiobankPrevalence differencesUKBAncestry groupsRisk scoreDisease burdenEuropean descentAfrican descentSex differencesSex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias
He J, Cabrera‐Mendoza B, Friligkou E, Mecca A, van Dyck C, Pathak G, Polimanti R. Sex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias. Alzheimer's & Dementia 2025, 21: e70215. PMID: 40421744, PMCID: PMC12107445, DOI: 10.1002/alz.70215.Peer-Reviewed Original ResearchConceptsSocioeconomic factorsFamily historySocioeconomic statusFamily history of Alzheimer's diseaseAssociation of socioeconomic factorsHistory of Alzheimer's diseaseUs Research ProgramCognitive performanceHigher socioeconomic statusSex-specific associationsAlzheimer's Disease AssessmentSex differencesUK BiobankADRDAlzheimer's diseaseGenetically informed analysesDementiaSample sizeSexGenetic analysisAlzheimerLimited informationStatusConfoundingBiobankSex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation
He J, Cabrera-Mendoza B, De Angelis F, Pathak G, Koller D, Curhan S, Curhan G, Mecca A, van Dyck C, Polimanti R. Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation. Brain 2024, 147: 3395-3408. PMID: 38454550, PMCID: PMC11449129, DOI: 10.1093/brain/awae077.Peer-Reviewed Original ResearchImaging-derived phenotypesHearing difficultiesBrain imaging-derived phenotypesSex-combined analysisLatent causal variable analysesMendelian randomization approachGeneralized linear regression analysisLocal genetic correlation analysisMultivariate generalized linear regression analysisGenome-wide association studiesLatent causal variableGenetic correlation analysisGenetic correlationsLocal genetic correlationMendelian randomizationPeripheral auditory systemOlder adultsGWAS dataLinear regression analysisHealth burdenGenomic regionsAssociation studiesPleiotropic regionsSex differencesTranscriptome regulationTime Trends and Predictions of Suicide Mortality for People Aged 70 Years and Over From 1990 to 2030 Based on the Global Burden of Disease Study 2017
He J, Ouyang F, Qiu D, Li L, Li Y, Xiao S. Time Trends and Predictions of Suicide Mortality for People Aged 70 Years and Over From 1990 to 2030 Based on the Global Burden of Disease Study 2017. Frontiers In Psychiatry 2021, 12: 721343. PMID: 34646174, PMCID: PMC8502866, DOI: 10.3389/fpsyt.2021.721343.Peer-Reviewed Original ResearchSub-Saharan AfricaSuicide mortality ratesSocio-demographic IndexElderly mortality rateSuicide mortalitySuicide ratesMortality changesGlobal Burden of Disease StudySouthern Latin AmericaLatin AmericaBurden of Disease StudySub-SaharanWestern EuropeHighest suicide ratesSDGs indicatorsPrevention policiesTrends of suicide mortalityEast AsiaSouth KoreaAfricaCountriesReduce suicide ratesCzech RepublicGlobal burdenPeopleIncidence trends of major depressive disorder in China: an age-period-cohort modeling study
He J, Ouyang F, Li L, Qiu D, Li Y, Xiao S. Incidence trends of major depressive disorder in China: an age-period-cohort modeling study. Journal Of Affective Disorders 2021, 288: 10-16. PMID: 33839553, DOI: 10.1016/j.jad.2021.03.075.Peer-Reviewed Original ResearchConceptsYears age groupCohort effectsIncidence rateIncidence trendsMDD incidence ratesRate ratiosAge-standardized incidence rateGlobal Burden of Disease StudyAge groupsAge-period-cohort analysisMajor depressive disorder dataPeriod rate ratiosBurden of Disease StudyCohort rate ratiosMajor depressive disorderLongitudinal age curvesPublic health problemDepressive disorderBirth cohortMDD incidenceNet driftGlobal burdenHealth problemsIncidence dataDisease Study
2026
Genome-wide investigation highlights global and local pleiotropy linking neurodevelopmental disorders to acquired hearing problems
Zhang Q, Cabrera-Mendoza B, Chen Q, Davtian D, Qiu D, He J, Polimanti R. Genome-wide investigation highlights global and local pleiotropy linking neurodevelopmental disorders to acquired hearing problems. Psychological Medicine 2026, 56: e32. PMID: 41593863, DOI: 10.1017/s0033291726103201.Peer-Reviewed Original ResearchConceptsLocal genetic correlationDrug repurposing analysisPolygenic overlapChromosomal regionsGenetic correlationsGenome-wide investigationConcordant effect directionsHearing problemsCausal variantsBrain imaging phenotypesNeurodevelopmental disordersPathogenic processesMolecular functionsBiological processesPleiotropyPleiotropic effectsAttention-deficit/hyperactivity disorderAssociated with hearing problemsCellular componentsAutism spectrum disorderExtrinsic factorsBiological mechanismsHearing functionSmoking initiationVariantsAssessing the comorbidity between asthma and depression through polygenic risk scoring and time-to-event models
Wang X, He J, Cabrera-Mendoza B, Qiu D, Mao Z, Gu W, Liu Y, Kim J, Polimanti R. Assessing the comorbidity between asthma and depression through polygenic risk scoring and time-to-event models. BMC Medicine 2026, 24: 101. PMID: 41572266, PMCID: PMC12910895, DOI: 10.1186/s12916-026-04646-w.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresMendelian randomizationOne-sample Mendelian randomizationOne-sample MR analysisDepression polygenic risk scoresRisk scoreRisk of developing depressionUs Research ProgramGene setsComorbidity statusGenome-wide association studiesQuality of lifeGene set analysisMR analysisCox proportional-hazards modelAsthma riskPolygenic riskProportional-hazards modelPotential confoundersConclusionsGenetic predispositionGenetic riskDrug repurposing analysisGenetic liabilityAssociation studiesTime-to-event modelsGenomic Studies of Suicidal Thoughts and Behaviors in Latin American Populations: A Systematic Review
Cabrera-Mendoza B, Panzenhagen A, de Anda-Jáuregui G, He J, Magalhaes P, Martínez-Magaña J, Martínez-Levy G, Qiu D, Sotelo D, Torres D, Medrano J, Vidal G, Velásquez M, Nicolini H, Polimanti R, Kaster M, Docherty A, Kimbrel N, Genis-Mendoza A, Ito L, Shansis F, Rovaris D, Folego-Temoteo I, Fries G, Consortium S. Genomic Studies of Suicidal Thoughts and Behaviors in Latin American Populations: A Systematic Review. Biological Psychiatry 2026 PMID: 41539590, PMCID: PMC12969891, DOI: 10.1016/j.biopsych.2025.12.009.Peer-Reviewed Original ResearchGenomic studiesGenomic researchEpigenetic studiesFunctional annotation resourcesMolecular studiesAncestry-specific lociStress response pathwaysPolygenic score studiesGenome-wideQ-Genie toolImmune-related processesQ-GenieGene studiesSystematic reviewTranscriptomic markersMeta-analysesBiology of suicidal behaviorStudies of suicidal ideationRandom-effects meta-analysesNonsuicidal Self-InjuryAnnotation resourcesRisk of biasNewcastle-Ottawa ScaleStudy of suicideHispanic/Latinx individuals
2025
The effect of cumulative exposure to unhealthy behavioral lifestyles on incident primary dyslipidemia: a prospective study from the Chinese government employee cohort
Li L, Li Y, Zhang C, He J, Ouyang F, Li J, Luo D, Hong X, Xiao S. The effect of cumulative exposure to unhealthy behavioral lifestyles on incident primary dyslipidemia: a prospective study from the Chinese government employee cohort. Lipids In Health And Disease 2025, 24: 380. PMID: 41361430, PMCID: PMC12683899, DOI: 10.1186/s12944-025-02801-5.Peer-Reviewed Original ResearchPopulation attributable fractionUnhealthy lifestylePoor sleep qualityBehavioral lifestyleSedentary behaviorLifestyle scoreUnhealthy dietPhysical exerciseSleep qualityClusters of lifestylesCombination of poor dietCumulative exposurePublic health interventionsDose-dependent risk factorHigh-risk clustersCox proportional hazards modelsPrimary dyslipidemiaIncidence of PDRisk of PDPhysical inactivityAttributable fractionHealth interventionsProportional hazards modelPoor dietSubstantial disease burdenUnderstanding the Comorbidities Among Psychiatric Disorders, Chronic Low Back Pain, and Spinal Degenerative Disease Using Observational and Genetically Informed Analyses
Qiu D, Friligkou E, He J, Cabrera-Mendoza B, Aslan M, Gupta M, Polimanti R. Understanding the Comorbidities Among Psychiatric Disorders, Chronic Low Back Pain, and Spinal Degenerative Disease Using Observational and Genetically Informed Analyses. Biological Psychiatry Global Open Science 2025, 5: 100588. PMID: 41036474, PMCID: PMC12483661, DOI: 10.1016/j.bpsgos.2025.100588.Peer-Reviewed Original ResearchChronic low back painSpinal degenerative diseaseLow back painPolygenic risk scoresMendelian randomizationBack painOne-sample Mendelian randomizationOne-sample MRRisk scoreUs Research ProgramPsychiatric disordersMultinominal regression modelGenetically informed analysesHealth outcomesMental illnessAlcohol use disorderPosttraumatic stress disorderDegenerative diseasesSociocultural factorsControl participantsRegression modelsUse disorderAssociated with differencesComorbidity patternsStress disorder
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