2023
Isradipine therapy in Cacna1dIle772Met/+ mice ameliorates primary aldosteronism and neurologic abnormalities
Stölting G, Dinh H, Volkert M, Hellmig N, Schewe J, Hennicke L, Seidel E, Oberacher H, Zhang J, Lifton R, Urban I, Long M, Rivalan M, Nottoli T, Scholl U. Isradipine therapy in Cacna1dIle772Met/+ mice ameliorates primary aldosteronism and neurologic abnormalities. JCI Insight 2023, 8: e162468. PMID: 37698934, PMCID: PMC10619505, DOI: 10.1172/jci.insight.162468.Peer-Reviewed Original ResearchConceptsPrimary aldosteronismNeurologic abnormalitiesZona glomerulosaIntracellular calciumElevated aldosterone/renin ratioCalcium channel blocker isradipineAldosterone/renin ratioL-type calcium channel Cav1.3Aldosterone-producing lesionsAdrenal aldosterone-producing adenomaHigh-salt dietTonic-clonic seizuresChannel blocker isradipineReduced body weightAldosterone-producing adenomaTherapy of patientsElevated intracellular calciumFunction mutationsDe novo germline mutationsDays of ageIsradipine therapyAldosterone levelsRenin ratioSerum aldosteroneRotarod test
2013
Dynamic Migration and Cell‐Cell Interactions of Early Reprogramming Revealed by High‐Resolution Time‐Lapse Imaging
Megyola CM, Gao Y, Teixeira AM, Cheng J, Heydari K, Cheng E, Nottoli T, Krause DS, Lu J, Guo S. Dynamic Migration and Cell‐Cell Interactions of Early Reprogramming Revealed by High‐Resolution Time‐Lapse Imaging. Stem Cells 2013, 31: 895-905. PMID: 23335078, PMCID: PMC4309553, DOI: 10.1002/stem.1323.Peer-Reviewed Original ResearchConceptsCell-cell interactionsEarly reprogrammingDynamic cell-cell interactionsSingle-cell resolutionTime-lapse microscopyE-cadherin inhibitionTime-lapse imagingPluripotency inductionInduced pluripotencyGranulocyte-monocyte progenitorsPluripotent cellsReprogrammingMolecular mechanismsCell resolutionCell migrationCellular interactionsGenetic makeupE-cadherinSatellite coloniesExperimental systemHematopoietic stateSource cellsRare cellsColoniesComplex mechanismsKinesin 5B (KIF5B) Is Required for Progression through Female Meiosis and Proper Chromosomal Segregation in Mitotic Cells
Kidane D, Sakkas D, Nottoli T, McGrath J, Sweasy JB. Kinesin 5B (KIF5B) Is Required for Progression through Female Meiosis and Proper Chromosomal Segregation in Mitotic Cells. PLOS ONE 2013, 8: e58585. PMID: 23560038, PMCID: PMC3613343, DOI: 10.1371/journal.pone.0058585.Peer-Reviewed Original ResearchConceptsMitotic cell divisionCell divisionKinesin 5BChromosomal segregationMitotic cellsCell developmentGerminal vesicle breakdownKnockdown of KIF5BProper chromosomal segregationChromosomal segregation defectsFemale meiosisSegregation defectsChromosomal stabilityRNA interferenceChromosomal instabilityFirst polar bodyMouse oocytesKIF5BMolecular motorsPolar bodyVesicle breakdownBirth defectsDivisionCellsMeiosis
2008
Chimeric mice reveal clonal development of pancreatic acini, but not islets
Swenson ES, Xanthopoulos J, Nottoli T, McGrath J, Theise ND, Krause DS. Chimeric mice reveal clonal development of pancreatic acini, but not islets. Biochemical And Biophysical Research Communications 2008, 379: 526-531. PMID: 19116141, PMCID: PMC2657659, DOI: 10.1016/j.bbrc.2008.12.104.Peer-Reviewed Original ResearchConceptsStem/progenitor cellsMultiple progenitorsAdult mouse small intestineMale ES cellsProgenitor cellsFemale blastocystsCrypt stem cellsClonal descendantsES cellsY chromosomeChimeric miceFemale cellsIntestinal crypt stem cellsExocrine pancreatic aciniFemale epithelial cellsClonal developmentStem cellsSitu hybridizationMouse small intestineEpithelial cellsIntestinal cryptsProgenitorsPancreatic aciniCellsPancreatic islets
2002
Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development.
Auman HJ, Nottoli T, Lakiza O, Winger Q, Donaldson S, Williams T. Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development. Development 2002, 129: 2733-47. PMID: 12015300, DOI: 10.1242/dev.129.11.2733.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlastocystBreast NeoplasmsDNA-Binding ProteinsEmbryo ImplantationEmbryonic and Fetal DevelopmentFemaleGene Expression Regulation, DevelopmentalGenotypeHumansMiceMice, KnockoutMorphogenesisPlacentaPolymerase Chain ReactionPregnancyRestriction MappingTranscription Factor AP-2Transcription FactorsConceptsExtra-embryonic lineagesAP-2gammaAnterior-posterior patterningStem cell maintenanceEarly postimplantation developmentExtra-embryonic tissuesAcid-responsive genesAP-2 familyRetinoic acid-responsive geneTrophoblast-specific expressionMaternal-embryonic interfaceMammalian developmentDays post coitumExtra-embryonic membranesCell maintenanceTranscription factorsEmbryonic developmentGene disruptionBiological functionsMouse embryosPostimplantation developmentPreimplantation embryosMutantsMolecular analysisNormal development