Featured Publications
Ketamine induces immediate and delayed alterations of OCD-like behavior
Thompson SL, Welch AC, Iourinets J, Dulawa SC. Ketamine induces immediate and delayed alterations of OCD-like behavior. Psychopharmacology 2020, 237: 627-638. PMID: 31927606, DOI: 10.1007/s00213-019-05397-8.Peer-Reviewed Original ResearchConceptsOCD-like behaviorPrepulse inhibitionTherapeutic effectH postinjectionNoncompetitive NMDA receptor antagonistOCD patientsAnti-OCD effectsRationaleObsessive-compulsive disorderNMDA receptor antagonistRapid therapeutic effectPretreatment time pointsAcute ketaminePharmacological monotherapyKetamine pretreatmentKetamine treatmentPPI deficitsReuptake inhibitorsReceptor antagonistLow doseMin postinjectionPsychiatric disordersDelayed alterationsResponse rateHigh dosesKetamineBtbd3 expression regulates compulsive-like and exploratory behaviors in mice
Thompson SL, Welch AC, Ho EV, Bessa JM, Portugal-Nunes C, Morais M, Young JW, Knowles JA, Dulawa SC. Btbd3 expression regulates compulsive-like and exploratory behaviors in mice. Translational Psychiatry 2019, 9: 222. PMID: 31501410, PMCID: PMC6733800, DOI: 10.1038/s41398-019-0558-7.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderKnockout miceCompulsive-like behaviorLimbic cortico-striatoExploratory behaviorThalamo-cortical circuitsMarble-burying testPrimary sensory cortexNeural circuit formationDendritic morphologyImpaired goal-directed behaviorAnterior cingulate cortexGoal-directed behaviorChronic treatmentSpine densityCortico-striatoMediodorsal thalamusDendritic pruningSensory cortexNeonatal developmentAnterior cingulateCingulate cortexCircuit formationPotential risk genesMice
2023
Mice lacking Ptprd exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating
Ho E, Welch A, Thompson S, Knowles J, Dulawa S. Mice lacking Ptprd exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating. PLOS ONE 2023, 18: e0277446. PMID: 37205689, PMCID: PMC10198499, DOI: 10.1371/journal.pone.0277446.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleGenome-Wide Association StudyGenotypeGoalsMaleMiceMice, KnockoutObsessive-Compulsive DisorderPrepulse InhibitionReceptor-Like Protein Tyrosine Phosphatases, Class 2Sensory GatingConceptsProtein tyrosine phosphatase receptor type DGenome-wide association studiesProtein tyrosine phosphatase familyTyrosine phosphatase familyReceptor type DPhosphatase familyAssociation studiesGenetic studiesCell adhesionPTPRDNest-building behaviorEffect of genotypeSynaptic specificationNeuropsychiatric phenotypesTraitsConstitutive lackKnockout miceKO miceGatingLociBuilding behaviorMicePhenotype
2015
Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation
Ho EV, Thompson SL, Katzka WR, Sharifi MF, Knowles JA, Dulawa SC. Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation. Psychopharmacology 2015, 233: 57-70. PMID: 26423528, DOI: 10.1007/s00213-015-4086-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCorpus StriatumDesipramineExploratory BehaviorFemaleFluoxetineIndolesMiceMice, Inbred C57BLObsessive-Compulsive DisorderReceptor, Serotonin, 5-HT1BSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor AntagonistsSerotonin Receptor AgonistsStereotyped BehaviorTreatment OutcomeConceptsAcute treatmentFos expressionDorsal striatumOCD treatmentStriatal activationReceptor agonist treatmentEffective OCD treatmentOpen-field behaviorChronic fluoxetineAgonist treatmentObsessive-compulsive disorderChronic pretreatmentLocomotor stereotypySeparate miceNeuronal activationDrug treatmentTreatment preventsRepetitive behaviorsOCD pathophysiologyBrain regionsOrbitofrontal cortexBehavioral effectsRU24969Inhibition deficitsBrain activation