2024
Laboratory Management of Mammalian Hosts for Ixodes scapularis -Host-Pathogen Interaction Studies.
Narasimhan S, Cibichakravarthy B, Wu M, Holter M, Walsh C, Goodrich J. Laboratory Management of Mammalian Hosts for Ixodes scapularis -Host-Pathogen Interaction Studies. Comparative Medicine 2024, 74: 235-245. PMID: 39289828, PMCID: PMC11373684, DOI: 10.30802/aalas-cm-24-036.Peer-Reviewed Original ResearchConceptsTick feedingHard-bodied ticksTick speciesArtificial membrane feedingHard ticksMammalian hostsAnimal healthHost-pathogen interaction studiesIxodes scapularisTicksManagement practicesNatural geographic rangePotential vectorsRabbit hostsFeedingHost healthGeographic rangePathogenic organismsInfectious prionsAnimal useRelevant speciesIxodesGuinea pigsLife cycleInteraction studies
2023
Tick salivary glycans – a sugar-coated tick bite
Karim S, Leyva-Castillo J, Narasimhan S. Tick salivary glycans – a sugar-coated tick bite. Trends In Parasitology 2023, 39: 1100-1113. PMID: 37838514, DOI: 10.1016/j.pt.2023.09.012.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCertain tick speciesDisease-causing pathogensNon-natural host speciesTick resistanceTick speciesTick feedingTick salivaPathogen transmissionTick bite siteMeat consumptionHematophagous arthropodsHost speciesTick biteRed meat consumptionMeat allergySuccessful feedingRed meat allergySpeciesTicksFeedingAllergic responsesImmune responseArthropodsCurrent knowledgePathogens
2022
Immunization of guinea pigs with cement extract induces resistance against Ixodes scapularis ticks
Lynn GE, Černý J, Kurokawa C, Diktaş H, Matias J, Sajid A, Arora G, DePonte K, Narasimhan S, Fikrig E. Immunization of guinea pigs with cement extract induces resistance against Ixodes scapularis ticks. Ticks And Tick-borne Diseases 2022, 13: 102017. PMID: 35963188, DOI: 10.1016/j.ttbdis.2022.102017.Peer-Reviewed Original ResearchTick salivaAnti-tick vaccinesTick-host interfaceSpecific protective antigensTick engorgement weightIxodes scapularis ticksTick speciesTick feedingEngorgement weightFeeding ticksHost resistanceTickborne pathogensDisease agentsAnimal hostsIxodes scapularisFemale I. scapularisI. scapularisScapularis ticksTicksImportant vectorTick detachmentPrimary vectorMidgut extractsProtective antigenHematophagous parasites
2021
Grappling with the tick microbiome
Narasimhan S, Swei A, Abouneameh S, Pal U, Pedra JHF, Fikrig E. Grappling with the tick microbiome. Trends In Parasitology 2021, 37: 722-733. PMID: 33962878, PMCID: PMC8282638, DOI: 10.1016/j.pt.2021.04.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTick microbiomeRelated tick speciesMultiple human pathogensHost preferenceSequencing technologiesTick biologyHuman pathogensMicrobiomeMechanistic insightsTick speciesLife cycleIxodes pacificusIxodes scapularisIxodid ticksCausative agentNorth AmericaBorrelia burgdorferiPredominant vectorBiological variablesHabitatsPacificusBiologySpeciesPathogensPotential impacts of climate change on medically important tick species in North America.
Lynn G, Narasimhan S, Fikrig E. Potential impacts of climate change on medically important tick species in North America. 2021, 145-151. DOI: 10.1079/9781789249637.0021.Chapters