Featured Publications
Widespread implementations of interactive social gaze neurons in the primate prefrontal-amygdala networks
Dal Monte O, Fan S, Fagan NA, Chu CJ, Zhou MB, Putnam PT, Nair AR, Chang SWC. Widespread implementations of interactive social gaze neurons in the primate prefrontal-amygdala networks. Neuron 2022, 110: 2183-2197.e7. PMID: 35545090, PMCID: PMC9262836, DOI: 10.1016/j.neuron.2022.04.013.Peer-Reviewed Original ResearchPrefrontal–amygdala circuits in social decision-making
Gangopadhyay P, Chawla M, Dal Monte O, Chang SWC. Prefrontal–amygdala circuits in social decision-making. Nature Neuroscience 2020, 24: 5-18. PMID: 33169032, PMCID: PMC7899743, DOI: 10.1038/s41593-020-00738-9.Peer-Reviewed Original ResearchConceptsSocial behaviorSystems neuroscience perspectivePrefrontal-amygdala pathwaysPrefrontal-amygdala circuitsPrefrontal cortical regionsSocial cognitionNeuroscience perspectiveNeural basisNeuropeptide oxytocinBrains of primatesNeural mechanismsCortical regionsNon-human primatesSpecific instantiationSocial constructMultiple levelsCognitionNeuronal activityMultiple animal speciesNeurobiologyAmygdalaBehaviorUnderpinningsPrimatesConstructs
2023
Beyond Cortex: The Evolution of the Human Brain
Chin R, Chang SWC, Holmes AJ. Beyond Cortex: The Evolution of the Human Brain. Psychological Review 2023, 130: 285-307. PMID: 35420848, DOI: 10.1037/rev0000361.Peer-Reviewed Original ResearchConceptsHuman brain evolutionBrain evolutionEvolutionary lineagesEvolutionary forcesEvolutionary pressureBody sizeHuman brain developmentHuman evolutionCurrent understandingBrain developmentDiverse setStudy of behaviorComprehensive viewBrain biologyLineagesEvolutionBiologyStriking increaseVast majorityCritical importanceAnimal modelsNonhuman primates
2021
Increasing Central Serotonin with 5-hydroxytryptophan Disrupts the Inhibition of Social Gaze in Nonhuman Primates
Weinberg-Wolf HB, Fagan N, Dal Monte O, Chang SWC. Increasing Central Serotonin with 5-hydroxytryptophan Disrupts the Inhibition of Social Gaze in Nonhuman Primates. Journal Of Neuroscience 2021, 42: 670-681. PMID: 34862190, PMCID: PMC8805615, DOI: 10.1523/jneurosci.0413-21.2021.Peer-Reviewed Original ResearchConceptsSocial gaze behaviorAbility of monkeysSocial gazeGaze behaviorMotivational stateControl imagesReaction timeCentral serotonin levelsNonhuman primatesSocial orientingGaze responsesSerotonergic interventionsModulatory relationshipCausal evidenceEye movementsTranslational insightsGazeDistinct aspectsDisruptive effectsBehavioral changesSerotonergic systemPupil constrictionCausal impactCentral serotoninFlexible orientationToward a holistic view of value and social processing in the amygdala: Insights from primate behavioral neurophysiology
Putnam PT, Chang SWC. Toward a holistic view of value and social processing in the amygdala: Insights from primate behavioral neurophysiology. Behavioural Brain Research 2021, 411: 113356. PMID: 33989727, PMCID: PMC8238892, DOI: 10.1016/j.bbr.2021.113356.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAnimalsCognitionEmotionsFearHumansNeuronsNeurophysiologyPrimatesSocial BehaviorConceptsSocial behaviorSocial stimuliValue-related processesNegative emotional processesAspects of cognitionReward-related processesDistinct brain regionsSocial processingEmotional processesAmygdala's roleNeural basisPositive affectHolistic hypothesisPrimate neurophysiologyNeurophysiological mechanismsBehavioral neurophysiologySocial interactionValue processingModern neuroscienceTemporal lobeBrain regionsAmygdalaStimuliNeurophysiologyProcessingSocial processing by the primate medial frontal cortex
Putnam PT, Chang SWC. Social processing by the primate medial frontal cortex. International Review Of Neurobiology 2021, 158: 213-248. PMID: 33785146, PMCID: PMC8232543, DOI: 10.1016/bs.irn.2020.12.003.Peer-Reviewed Original ResearchConceptsPrimate medial frontal cortexMedial frontal cortexFrontal cortexSocial interactionSocial behaviorSocial information processingAdaptive social interactionsNon-social behaviorsComplex social behaviorsSocial processingInformation processing systemsNeurophysiology literatureVicarious learningSocial partnersInformation processingSocial monitoringNeuronal substratesBrain regionsUnique contributionNeurophysiology experimentsSocial functionCortexNeural algorithmDecision-making processNonhuman primates
2018
An integrated framework for the role of oxytocin in multistage social decision‐making
Piva M, Chang SWC. An integrated framework for the role of oxytocin in multistage social decision‐making. American Journal Of Primatology 2018, 80: e22735. PMID: 29350419, PMCID: PMC6053333, DOI: 10.1002/ajp.22735.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalCognitionDecision MakingHumansOxytocinPrimatesRodentiaSocial BehaviorConceptsEffects of oxytocinSocial behaviorWithdrawal hypothesisSocial salience hypothesisCertain social situationsRole of oxytocinInfluence of oxytocinNeural evidenceProsocial actionsSocial stimuliProsocial choicesApproach behaviorSalience hypothesisSocial salienceSocial decisionsAntisocial behaviorSocial situationsOxytocin administrationWithdrawal behaviorSensory inputBehavioral outputSensory perceptionOverarching theoryDisparate theoriesProminent hypothesis