2023
Improvement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine model
Avendaño R, Midgett D, Melvinsdottir I, Thorn S, Uman S, Pickell Z, Lee S, Liu Z, Mamarian M, Duncan J, Spinale F, Burdick J, Sinusas A. Improvement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine model. Journal Of Applied Physiology 2023, 135: 405-420. PMID: 37318987, PMCID: PMC10538987, DOI: 10.1152/japplphysiol.00342.2022.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHydrogelsMyocardial InfarctionMyocardiumPrecision MedicineSwineVentricular Function, LeftVentricular RemodelingConceptsMyocardial infarctionIntramyocardial deliveryLV hemodynamicsControl groupFunctional indexEarly post-myocardial infarctionSystolic functional indicesMyocardial performance indexAnterolateral myocardial infarctionLeft anterior descendingPressure-volume loop areaLeft ventricular remodelingGlobal LV functionLV functional changesPost-myocardial infarctionSupply/demand ratioRegional LV strainHydrogel groupTei indexEjection fractionHeart failureAnterior descendingCircumflex arteryLV functionAortic pressure
2022
Co-attention spatial transformer network for unsupervised motion tracking and cardiac strain analysis in 3D echocardiography
Ahn S, Ta K, Thorn S, Onofrey J, Melvinsdottir I, Lee S, Langdon J, Sinusas A, Duncan J. Co-attention spatial transformer network for unsupervised motion tracking and cardiac strain analysis in 3D echocardiography. Medical Image Analysis 2022, 84: 102711. PMID: 36525845, PMCID: PMC9812938, DOI: 10.1016/j.media.2022.102711.Peer-Reviewed Original ResearchMeSH KeywordsEchocardiographyEchocardiography, Three-DimensionalHeartHumansMyocardial InfarctionVentricular Dysfunction, LeftConceptsSpatial transformer networkMotion trackingNoisy displacement fieldReliable motion estimationMotion tracking methodCardiac strain analysisTransformer networkDisplacement fieldDisplacement pathsMotion fieldTracking methodMotion estimationExperimental resultsStrain analysisSuperior performanceTemporal constraintsCardiac motionTrackingRegularization functionDependent featuresEchocardiography imagesNetworkPrior assumptionsFieldMatrix Metalloproteinase-Targeted SPECT/CT Imaging for Evaluation of Therapeutic Hydrogels for the Early Modulation of Post-Infarct Myocardial Remodeling
Thorn SL, Shuman JA, Stacy MR, Purcell BP, Doviak H, Burdick JA, Spinale FG, Sinusas AJ. Matrix Metalloproteinase-Targeted SPECT/CT Imaging for Evaluation of Therapeutic Hydrogels for the Early Modulation of Post-Infarct Myocardial Remodeling. Journal Of Cardiovascular Translational Research 2022, 16: 155-165. PMID: 35697979, PMCID: PMC10836411, DOI: 10.1007/s12265-022-10280-7.Peer-Reviewed Original ResearchCineCT platform for in vivo and ex vivo measurement of 3D high resolution Lagrangian strains in the left ventricle following myocardial infarction and intramyocardial delivery of theranostic hydrogel
Midgett D, Thorn S, Ahn S, Uman S, Avendano R, Melvinsdottir I, Lysyy T, Kim J, Duncan J, Humphrey J, Papademetris X, Burdick J, Sinusas A. CineCT platform for in vivo and ex vivo measurement of 3D high resolution Lagrangian strains in the left ventricle following myocardial infarction and intramyocardial delivery of theranostic hydrogel. Journal Of Molecular And Cellular Cardiology 2022, 166: 74-90. PMID: 35227737, PMCID: PMC9035115, DOI: 10.1016/j.yjmcc.2022.02.004.Peer-Reviewed Original ResearchAnimalsHeart VentriclesHydrogelsMyocardial InfarctionSwineTheranostic NanomedicineVentricular RemodelingRegional heterogeneity in determinants of atrial matrix remodeling and association with atrial fibrillation vulnerability postmyocardial infarction
Stacy MR, Lin BA, Thorn SL, Lobb DC, Maxfield MW, Novack C, Zellars KN, Freeburg L, Akar JG, Sinusas AJ, Spinale FG. Regional heterogeneity in determinants of atrial matrix remodeling and association with atrial fibrillation vulnerability postmyocardial infarction. Heart Rhythm 2022, 19: 847-855. PMID: 35066183, PMCID: PMC9064890, DOI: 10.1016/j.hrthm.2022.01.022.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtrial FibrillationAtrial RemodelingMatrix MetalloproteinasesMyocardial InfarctionMyocardiumSwineVentricular RemodelingConceptsAtrial fibrillationMyocardial infarctionRight atrial regionsAtrial regionsPost-MIMMP activityMatrix metalloproteinasesMMP/TIMP profilesNew-onset atrial fibrillationLeft atrial regionsMMP/TIMP expressionLeft atrial appendageMatrix remodelingElectrical stimulation protocolFibrillar collagen contentExtracellular matrix remodelingAF vulnerabilityTIMP profilesAtrial appendagePostmyocardial infarctionMyocardial substrateStimulation protocolNoninvasive molecular imagingTIMP expressionTissue inhibitor
2019
Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling
Thorn SL, Barlow SC, Feher A, Stacy MR, Doviak H, Jacobs J, Zellars K, Renaud JM, Klein R, deKemp RA, Khakoo AY, Lee T, Spinale FG, Sinusas AJ. Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling. Circulation Cardiovascular Imaging 2019, 12: e009055. PMID: 31707811, PMCID: PMC7250243, DOI: 10.1161/circimaging.119.009055.Peer-Reviewed Original ResearchConceptsMyocardial blood flowSingle photon emissionBlood flowRecombinant TIMP-3Matrix metalloproteinasesR injuryTomography/Intracoronary deliveryMMP activationPost-myocardial infarction remodelingSubsequent left ventricular remodelingHybrid single-photon emissionDual-isotope single-photon emissionTomography/Computed Tomography ImagingLeft ventricular remodelingIschemia/reperfusionPost-MI remodelingPost-myocardial infarctionComputed tomography (CT) imagingIntracoronary infusionVentricular functionSaline groupVentricular remodelingNoninvasive evaluationTreatment groups
2015
PET imaging of a collagen matrix reveals its effective injection and targeted retention in a mouse model of myocardial infarction
Ahmadi A, Thorn SL, Alarcon EI, Kordos M, Padavan DT, Hadizad T, Cron GO, Beanlands RS, DaSilva JN, Ruel M, deKemp RA, Suuronen EJ. PET imaging of a collagen matrix reveals its effective injection and targeted retention in a mouse model of myocardial infarction. Biomaterials 2015, 49: 18-26. PMID: 25725551, DOI: 10.1016/j.biomaterials.2015.01.016.Peer-Reviewed Original ResearchConceptsMyocardial infarctionPositron emission tomographyPET imagingMouse modelNon-invasive PET imagingCardiac regeneration therapyIschemic territoryPET resultsInfarcted myocardiumEmission tomographyCollagen matrixMyocardial injectionEarly retentionPromising modalityRegeneration therapyInfarctionLabeling efficiencyMyocardiumFluorescence imagingImagingBiodistributionInjectionQdot labelingEx
2014
The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardium
Ahmadi A, McNeill B, Vulesevic B, Kordos M, Mesana L, Thorn S, Renaud JM, Manthorp E, Kuraitis D, Toeg H, Mesana TG, Davis DR, Beanlands RS, DaSilva JN, deKemp RA, Ruel M, Suuronen EJ. The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardium. Biomaterials 2014, 35: 4749-4758. PMID: 24631247, DOI: 10.1016/j.biomaterials.2014.02.028.Peer-Reviewed Original ResearchConceptsMatrix therapyMouse myocardial infarction modelMyocardial infarction modelCardiac cell therapySynergistic therapeutic effectTherapeutic effectMyocardial perfusionParacrine propertiesInfarcted myocardiumAngiogenic cellsInfarction modelOverall efficacyTherapyCell therapyAngiogenic potentialCACSΑ5 integrinIntegrin α2EngraftmentIntegrin α5PerfusionCellsIntegrinsCollagen matrixCAC function
2012
18F-FDG Cell Labeling May Underestimate Transplanted Cell Homing: More Accurate, Efficient, and Stable Cell Labeling with Hexadecyl-4-[18F]Fluorobenzoate for in Vivo Tracking of Transplanted Human Progenitor Cells by Positron Emission Tomography
Zhang Y, Dasilva JN, Hadizad T, Thorn S, Kuraitis D, Renaud JM, Ahmadi A, Kordos M, Dekemp RA, Beanlands RS, Suuronen EJ, Ruel M. 18F-FDG Cell Labeling May Underestimate Transplanted Cell Homing: More Accurate, Efficient, and Stable Cell Labeling with Hexadecyl-4-[18F]Fluorobenzoate for in Vivo Tracking of Transplanted Human Progenitor Cells by Positron Emission Tomography. Cell Transplantation 2012, 21: 1821-1835. PMID: 22469629, DOI: 10.3727/096368911x637416.Peer-Reviewed Original ResearchConceptsCirculating Progenitor CellsPositron emission tomographyEmission tomographyCell therapyPET imagingCell transplantation groupProgenitor cellsCoronary artery ligationRat myocardial infarction modelInfarct border zoneHeart tissue sectionsMyocardial infarction modelBorder zoneCardiac cell therapyTransplantation groupIschemic/Artery ligationH posttransplantationBest modalityHuman progenitor cellsIntramyocardial injectionH postinjectionInjection siteTissue biodistributionInfarction model