2023
1901. High Prevalence of Latent Tuberculosis Infection in a Malaysian Prison
Zhang L, Shenoi S, Kamarulzaman A, Dhaliwal S, Ahmad A, Altice F. 1901. High Prevalence of Latent Tuberculosis Infection in a Malaysian Prison. Open Forum Infectious Diseases 2023, 10: ofad500.1729. PMCID: PMC10677608, DOI: 10.1093/ofid/ofad500.1729.Peer-Reviewed Original ResearchLatent tuberculosis infectionPrevalence of LTBIRisk of LTBITB preventive therapyIndependent risk factorTuberculin skin testC-reactive proteinActive TBPreventive therapyTuberculosis infectionRisk factorsHigh prevalenceMultivariable logistic regressionOpioid use disorderRisk of hepatotoxicityChest X-rayDrug use historyPaucity of dataLTBI treatmentHCV infectionHepatitis CHepatitis BMedian ageBlood testsSkin testCommunity health workers can be trained to identify patients eligible for tuberculosis preventive therapy, but encounter barriers to programme implementation in KwaZulu-Natal, South Africa
Norton S, Moll A, Madi J, Nkomo N, Brooks R, Andrews L, Shenoi S. Community health workers can be trained to identify patients eligible for tuberculosis preventive therapy, but encounter barriers to programme implementation in KwaZulu-Natal, South Africa. African Journal Of AIDS Research 2023, 22: 131-135. PMID: 37337826, DOI: 10.2989/16085906.2023.2213213.Peer-Reviewed Original ResearchConceptsTuberculosis preventive therapyCommunity health workersLargest HIV epidemicCause of deathNon-communicable diseasesHealth workersPreventive therapyRural resource-limited settingsHigh TB incidence ratesFurther implementation researchTB incidence rateRate of referralResource-limited settingsMedian ageTreatment initiationHIV epidemicIncidence rateRural South AfricaHIVInfectious diseasesTuberculosisImplementation researchScreening resultsDiseasePatientsPerceived stigma related to TB preventive therapy
Palacios C, Hough M, Shrestha R, Moll A, Kompala T, Andrews L, Shenoi S. Perceived stigma related to TB preventive therapy. The International Journal Of Tuberculosis And Lung Disease 2023, 27: 209-214. PMID: 36855038, DOI: 10.5588/ijtld.22.0570.Peer-Reviewed Original ResearchConceptsTB preventative therapyTB preventive therapyAnonymous cross-sectional surveyBurden of TBCommunity-dwelling adultsRural South African communityCross-sectional surveyPreventive therapyMean agePreventative therapyEndemic settingsPatient's familyKruskal-Wallis testStigma scoresRural South AfricaPoisson regressionNovel interventionsSouth African communityTherapyLess stigmaDescriptive statisticsFamily membersStigmaTBTwo-factor solution
2021
Factors associated with low tuberculosis preventive therapy prescription rates among health care workers in rural South Africa
Ahmed AA, Grammatico M, Moll AP, Malinga S, Makhunga P, Charalambous S, Ladines-Lim JB, Jones J, Choi K, Shenoi SV. Factors associated with low tuberculosis preventive therapy prescription rates among health care workers in rural South Africa. Global Health Action 2021, 14: 1979281. PMID: 34652990, PMCID: PMC8525921, DOI: 10.1080/16549716.2021.1979281.Peer-Reviewed Original ResearchConceptsTuberculosis preventive therapyHealth care workersPrimary healthcare clinicsLower prescription ratesPrescription ratesRural South AfricaCare workersIsoniazid preventative therapyIncidence of tuberculosisCross-sectional studyGovernment district hospitalsPreventive therapyMedian ageMultivariable analysisPreventative therapyDistrict hospitalHealthcare clinicsHCW trainingPatient disclosureTPT useConsolidated FrameworkLogistic regressionImplementation researchSelf-reported dataPrescribers
2020
1656. Factors associated with low TB preventative therapy prescription rates among healthcare workers in rural South Africa
Ahmed A, Grammatico M, Malinga S, Makhunga P, Moll A, Ladines-Lim J, Jones J, Choi K, Shenoi S. 1656. Factors associated with low TB preventative therapy prescription rates among healthcare workers in rural South Africa. Open Forum Infectious Diseases 2020, 7: s816-s817. PMCID: PMC7778258, DOI: 10.1093/ofid/ofaa439.1834.Peer-Reviewed Original ResearchPrimary care clinicsLower prescription ratesPrescription ratesHealthcare workersPatients' nondisclosureRural South AfricaConclusions Healthcare workersIsoniazid preventive therapyProfessional nursesRural district hospitalMedical officersCross-sectional surveyEligible patientsMortality benefitPreventive therapyMedian ageCare clinicsPreventative therapyTuberculosis incidenceDistrict hospitalSelf-reported knowledgePatientsHCW trainingMultivariate analysisPrescribers1644. “And the stick to fight TB is IPT”: Perspectives on TPT Implementation Among Senior Nurses in Rural South Africa
Grammatico M, Ahmed A, Grau L, Moll A, Shenoi S. 1644. “And the stick to fight TB is IPT”: Perspectives on TPT Implementation Among Senior Nurses in Rural South Africa. Open Forum Infectious Diseases 2020, 7: s811-s811. PMCID: PMC7777536, DOI: 10.1093/ofid/ofaa439.1824.Peer-Reviewed Original ResearchIsoniazid preventive therapyWorld Health OrganizationPreventative therapyMedian age 39 yearsSenior nursesTB preventative therapyPatient-level factorsPrimary health clinicsPrimary care clinicsAge 39 yearsHigh-volume clinicsHealth care experiencesResource-limited settingsBackground TuberculosisAntiretroviral therapyHigh tuberculosisChronic medicationsPill burdenPreventive therapyTB burdenHigh HIVCare clinicsConclusion NursesHIV prevalenceStandardized training program
2019
1673. Gendered Patterns of HIV, TB, and Other Primary Care Referrals in Rural South Africa
Choi K, Moll A, Shenoi S. 1673. Gendered Patterns of HIV, TB, and Other Primary Care Referrals in Rural South Africa. Open Forum Infectious Diseases 2019, 6: s612-s613. PMCID: PMC6809581, DOI: 10.1093/ofid/ofz360.1537.Peer-Reviewed Original ResearchPrimary care servicesRural South AfricaHazardous drinkingPositive screeningHealth concernIsoniazid preventive therapyLast clinic visitPrimary care referralsMultivariable logistic regressionHealth careCommunity health workersHealth-seeking behaviourCommunity-based servicesCare referralClinic visitsPreventive therapyMedian ageClinical outcomesSaharan AfricaHealthcare useHealth workersHIV effortsMore referralsCare servicesHIV
2017
Community Health Workers Can Strengthen Isoniazid Preventive Therapy Implementation in Rural KwaZulu-Natal, South Africa
Norton S, Moll A, Madi J, Nkomo N, Brooks R, Shenoi S. Community Health Workers Can Strengthen Isoniazid Preventive Therapy Implementation in Rural KwaZulu-Natal, South Africa. Open Forum Infectious Diseases 2017, 4: s119-s119. PMCID: PMC5632264, DOI: 10.1093/ofid/ofx163.146.Peer-Reviewed Original ResearchIsoniazid preventive therapyCommunity health workersRural KwaZulu-NatalHealth workersHigh TB incidence ratesDifferentiated care modelProportion of patientsHIV treatment programsTB incidence rateCause of deathResource limited settingsIPT initiationPreventive therapySecondary outcomesTB casesMedian agePrimary outcomeTB epidemicPreventive treatmentChronic diseasesIncidence rateSymptom screenCHW rolesCare modelTherapy implementation“It’s about my life”: facilitators of and barriers to isoniazid preventive therapy completion among people living with HIV in rural South Africa
Jacobson KB, Niccolai L, Mtungwa N, Moll AP, Shenoi SV. “It’s about my life”: facilitators of and barriers to isoniazid preventive therapy completion among people living with HIV in rural South Africa. AIDS Care 2017, 29: 936-942. PMID: 28147705, PMCID: PMC5545149, DOI: 10.1080/09540121.2017.1283390.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAmbulatory Care FacilitiesAntitubercular AgentsCounselingFemaleHealth Knowledge, Attitudes, PracticeHealth Services AccessibilityHIV InfectionsHumansIncidenceInterviews as TopicIsoniazidMalePatient ComplianceQualitative ResearchRural PopulationSocial StigmaSouth AfricaTrustTuberculosisConceptsIsoniazid preventive therapyIPT completionPreventive roleAbsence of symptomsHealth care workersKnowledge of TBHealth service deliveryResource-limited settingsHealth care systemRural KwaZulu-NatalAntiretroviral therapyHIV patientsHIV diagnosisPreventive therapyTherapy completionTB incidenceAppropriate counselingHealthcare workersIndividual patientsCare workersRural South AfricaHIVPatientsUnrelated conditionsIndividual semi-structured interviews
2015
Integrating Community-Based Interventions to Reverse the Convergent TB/HIV Epidemics in Rural South Africa
Gilbert JA, Long EF, Brooks RP, Friedland GH, Moll AP, Townsend JP, Galvani AP, Shenoi SV. Integrating Community-Based Interventions to Reverse the Convergent TB/HIV Epidemics in Rural South Africa. PLOS ONE 2015, 10: e0126267. PMID: 25938501, PMCID: PMC4418809, DOI: 10.1371/journal.pone.0126267.Peer-Reviewed Original ResearchConceptsTB/HIVHIV control strategiesMDR-TBXDR-TBHIV deathsHIV casesHIV epidemicRural South AfricaTB/HIV casesTB treatment delayIsoniazid preventive therapyDrug-resistant TBHIV treatment programsTreatment cure ratesHIV case findingHIV control effortsNovel screening programPreventive therapyTB casesTB treatmentTreatment delayHIV transmissionCure rateQuestionnaire's sensitivityScreening program