2024
Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei
Beaver A, Keneskhanova Z, Cosentino R, Weiss B, Awuoche E, Smallenberger G, Buenconsejo G, Crilly N, Smith J, Hakim J, Zhang B, Bobb B, Rijo-Ferreira F, Figueiredo L, Aksoy S, Siegel T, Mugnier M. Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei. Nature 2024, 1-8. PMID: 39478231, DOI: 10.1038/s41586-024-08151-z.Peer-Reviewed Original ResearchVariant surface glycoproteinAntigenic diversityAntigenic variationHigh-throughput sequencing approachDense variant surface glycoproteinPopulations of T. bruceiDynamics of antigenic variationGenomic repertoirePathogen diversificationSequencing approachExtravascular spaceTrypanosoma bruceiVariation in vivoHost immune systemAntigenic variation in vivoSurface glycoproteinSlow immune responseDiversitySwitching expressionParasite populations
2012
PGRP-LB is a maternally transmitted immune milk protein that influences symbiosis and parasitism in tsetse’s offspring
Wang J, Aksoy S. PGRP-LB is a maternally transmitted immune milk protein that influences symbiosis and parasitism in tsetse’s offspring. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 10552-10557. PMID: 22689989, PMCID: PMC3387098, DOI: 10.1073/pnas.1116431109.Peer-Reviewed Original ResearchConceptsMother's milkImmune deficiency (IMD) pathwayPGRP-LBHost immune systemImmune system developmentIntrauterine environmentNutritional supplementationDietary supplementationHyperimmune responseImmune systemImpact immunityNewborn progenyParasite infectionAdultsParasitized adultsPeptidoglycan recognition proteinsSuch adultsImmunitySupplementationAntitrypanosomal activityPivotal roleMilkInductionHost fecundityMilk proteins