2023
Sex Differences in Symptom Complexity and Door-to-Balloon Time in Patients With ST-Elevation Myocardial Infarction
Brush J, Chaudhry S, Dreyer R, D'Onofrio G, Greene E, Hajduk A, Lu Y, Krumholz H. Sex Differences in Symptom Complexity and Door-to-Balloon Time in Patients With ST-Elevation Myocardial Infarction. The American Journal Of Cardiology 2023, 197: 101-107. PMID: 37062667, PMCID: PMC10198892, DOI: 10.1016/j.amjcard.2023.03.009.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansMaleMyocardial InfarctionPercutaneous Coronary InterventionSex CharacteristicsST Elevation Myocardial InfarctionTime FactorsConceptsPercutaneous coronary interventionD2B timeSymptom complexityYoung womenChest painBalloon timeST-elevation myocardial infarctionSILVER-AMI StudySymptom phenotypeSex differencesPain symptomsCoronary interventionOlder patientsMyocardial infarctionOlder womenSTEMIOlder menSymptom patternsPresentation delayPatientsSymptom clustersLogistic regressionSymptomsWomenMean number
2022
A risk model for decline in health status after acute myocardial infarction among older adults
Hajduk A, Dodson J, Murphy T, Chaudhry S. A risk model for decline in health status after acute myocardial infarction among older adults. Journal Of The American Geriatrics Society 2022, 71: 1228-1235. PMID: 36519774, PMCID: PMC10089939, DOI: 10.1111/jgs.18162.Peer-Reviewed Original ResearchMeSH KeywordsAftercareAgedHealth StatusHumansMaleMyocardial InfarctionPatient DischargeProspective StudiesConceptsAcute myocardial infarctionHealth status declineImportant patient-centered outcomesPatient-centered outcomesMyocardial infarctionStatus declineHealth statusOlder adultsShort Form-12 Physical Component ScorePhysical component scoreProspective cohort studyRisk prediction modelLogistic regression modelsOlder adult survivorsPredictive risk modelRisk modelCohort studyPatient ageValidation cohortC-statisticRisk factorsHigh riskLower riskAdult survivorsHospitalizationRacial disparities among older adults with acute myocardial infarction: The SILVER‐AMI study
Demkowicz P, Hajduk A, Dodson J, Oladele C, Chaudhry S. Racial disparities among older adults with acute myocardial infarction: The SILVER‐AMI study. Journal Of The American Geriatrics Society 2022, 71: 474-483. PMID: 36415964, PMCID: PMC9957871, DOI: 10.1111/jgs.18084.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingBlack or African AmericanFemaleHealth Status DisparitiesHospitalizationHospitalsHumansMaleMyocardial InfarctionUnited StatesWhiteConceptsAcute myocardial infarctionFunctional impairmentGeriatric conditionsClinical characteristicsMyocardial infarctionBlack participantsOlder adultsRacial disparitiesRisk of mortalityMore functional impairmentSILVER-AMI StudyBlack older adultsYounger average ageUnadjusted oddsDaily livingAMI hospitalizationAverage ageGeriatric phenotypesUS hospitalsHospitalizationLogistic regressionMortalityImpairmentInfarctionUnintentional lossAssociation of Financial Strain With Mortality Among Older US Adults Recovering From an Acute Myocardial Infarction
Falvey JR, Hajduk AM, Keys CR, Chaudhry SI. Association of Financial Strain With Mortality Among Older US Adults Recovering From an Acute Myocardial Infarction. JAMA Internal Medicine 2022, 182: 445-448. PMID: 35188537, PMCID: PMC8861896, DOI: 10.1001/jamainternmed.2021.8569.Peer-Reviewed Original ResearchReply to: “Comment on: Falls in older adults after hospitalization for acute myocardial infarction”
Goldstein DW, Hajduk AM, Song X, Tsang S, Geda M, McClurken JB, Tinetti ME, Krumholz HM, Chaudhry SI. Reply to: “Comment on: Falls in older adults after hospitalization for acute myocardial infarction”. Journal Of The American Geriatrics Society 2022, 70: 1880-1881. PMID: 35332528, PMCID: PMC9177624, DOI: 10.1111/jgs.17742.Peer-Reviewed Original Research
2021
Factors Associated With Cardiac Rehabilitation Participation in Older Adults After Myocardial Infarction
Goldstein DW, Hajduk AM, Song X, Tsang S, Geda M, Dodson JA, Forman DE, Krumholz H, Chaudhry SI. Factors Associated With Cardiac Rehabilitation Participation in Older Adults After Myocardial Infarction. Journal Of Cardiopulmonary Rehabilitation And Prevention 2021, 42: 109-114. PMID: 34799530, PMCID: PMC8881286, DOI: 10.1097/hcr.0000000000000627.Peer-Reviewed Original ResearchMeSH KeywordsAftercareAgedCardiac RehabilitationHumansMyocardial InfarctionPatient DischargeProspective StudiesConceptsAcute myocardial infarctionUtilization of CRCardiac rehabilitationCR participationOlder adultsMyocardial infarctionSensory impairmentMultivariable-adjusted logistic regression modelsNationwide prospective cohort studyOlder AMI patientsCardiac rehabilitation participationProspective cohort studyYr of educationSILVER-AMI StudyLogistic regression modelsSecondary preventionClinical factorsCohort studyPatient ageIndependent predictorsAMI patientsRehabilitation participationPsychosocial factorsCR useExtensive baseline dataSex Differences in Symptom Phenotypes Among Older Patients with Acute Myocardial Infarction
Brush JE, Hajduk AM, Greene EJ, Dreyer RP, Krumholz HM, Chaudhry SI. Sex Differences in Symptom Phenotypes Among Older Patients with Acute Myocardial Infarction. The American Journal Of Medicine 2021, 135: 342-349. PMID: 34715061, PMCID: PMC8901454, DOI: 10.1016/j.amjmed.2021.09.022.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHospitalizationHumansMaleMyocardial InfarctionPhenotypeRisk FactorsSex CharacteristicsSex FactorsConceptsAcute myocardial infarctionMyocardial infarctionSymptom combinationsOlder patientsAcute myocardial infarction subgroupsAcute myocardial infarction admissionsMyocardial infarction subgroupsPatients 75 yearsMyocardial infarction admissionsSILVER-AMI StudySymptom phenotypeClinical studiesIndividual patientsMore symptomsPatientsInfarctionDiagnostic possibilitiesSymptomsWomenPerson interviewsMenCommon phenotypeSex differencesCliniciansPhenotypePresentation, Treatment, and Outcomes of Older Adults Hospitalized for Acute Myocardial Infarction According to Cognitive Status: The SILVER-AMI Study
Hajduk AM, Saczynski JS, Tsang S, Geda ME, Dodson JA, Ouellet GM, Goldberg RJ, Chaudhry SI. Presentation, Treatment, and Outcomes of Older Adults Hospitalized for Acute Myocardial Infarction According to Cognitive Status: The SILVER-AMI Study. The American Journal Of Medicine 2021, 134: 910-917. PMID: 33737057, PMCID: PMC8243828, DOI: 10.1016/j.amjmed.2021.03.003.Peer-Reviewed Original ResearchConceptsSevere cognitive impairmentAcute myocardial infarctionMyocardial infarctionCognitive impairmentOlder acute myocardial infarction patientsCognitive statusMultivariable-adjusted logistic regressionAcute myocardial infarction patientsOlder adultsRoutine cognitive screeningRisk of readmissionMedical record reviewRisk of deathPost-discharge periodMyocardial infarction patientsMyocardial infarction survivorsSILVER-AMI StudyComorbidity burdenHospital readmissionPoor outcomeRecord reviewFunctional statusInfarction patientsUnadjusted analysesInfarction survivors180-day readmission risk model for older adults with acute myocardial infarction: the SILVER-AMI study
Dodson JA, Hajduk AM, Murphy TE, Geda M, Krumholz HM, Tsang S, Nanna MG, Tinetti ME, Ouellet G, Sybrant D, Gill TM, Chaudhry SI. 180-day readmission risk model for older adults with acute myocardial infarction: the SILVER-AMI study. Open Heart 2021, 8: e001442. PMID: 33452007, PMCID: PMC7813425, DOI: 10.1136/openhrt-2020-001442.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionReadmission risk modelSelf-reported health statusMyocardial infarctionFunctional mobilityOlder adultsHealth statusDays of AMIFirst diastolic blood pressureChronic obstructive pulmonary diseaseIschemic ECG changesProspective cohort studyDiastolic blood pressureObstructive pulmonary diseaseLength of stayInitial heart rateFinal risk modelSILVER-AMI StudyRisk modelInitial hemoglobinCohort studyReadmission ratesBlood pressureEjection fractionHeart failure
2020
Risk Model for Decline in Activities of Daily Living Among Older Adults Hospitalized With Acute Myocardial Infarction: The SILVER‐AMI Study
Hajduk AM, Dodson JA, Murphy TE, Tsang S, Geda M, Ouellet GM, Gill TM, Brush JE, Chaudhry SI. Risk Model for Decline in Activities of Daily Living Among Older Adults Hospitalized With Acute Myocardial Infarction: The SILVER‐AMI Study. Journal Of The American Heart Association 2020, 9: e015555. PMID: 33000681, PMCID: PMC7792390, DOI: 10.1161/jaha.119.015555.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionDaily living declineSILVER-AMI StudyDaily livingOlder patientsMonths postdischargeMyocardial infarctionFunctional declineImportant patient-centered outcomesPoor long-term outcomesLonger hospital stayLong-term outcomesPatient-centered outcomesGeriatric impairmentsHospital stayAMI survivorsClinical variablesMean ageMedical recordsRisk factorsRestorative therapyPhysical activityAMI hospitalizationPsychosocial factorsUS hospitalsPresentation, Treatment, and Outcomes of the Oldest-Old Patients with Acute Myocardial Infarction: The SILVER-AMI Study
Gupta A, Tsang S, Hajduk A, Krumholz HM, Nanna MG, Green P, Dodson JA, Chaudhry SI. Presentation, Treatment, and Outcomes of the Oldest-Old Patients with Acute Myocardial Infarction: The SILVER-AMI Study. The American Journal Of Medicine 2020, 134: 95-103. PMID: 32805225, PMCID: PMC7752813, DOI: 10.1016/j.amjmed.2020.07.020.Peer-Reviewed Original ResearchConceptsOldest-old patientsMyocardial infarctionFunctional impairmentOlder patientsMobility impairmentsCox proportional hazards regressionMiddle-old patientsProportional hazards regressionAcute myocardial infarctionCase fatality rateAcute myocardial infarction hospitalizationsSILVER-AMI StudyYears of ageMyocardial infarction hospitalizationsChest painCoronary revascularizationAtypical presentationHazards regressionClinical variablesRisk factorsAdvanced agePrimary symptomsPatientsFatality rateHealth statusPatient and Cardiologist Perspectives on Shared Decision Making in the Treatment of Older Adults Hospitalized for Acute Myocardial Infarction
Grant EV, Summapund J, Matlock DD, Dickson V, Iqbal S, Patel S, Katz SD, Chaudhry SI, Dodson JA. Patient and Cardiologist Perspectives on Shared Decision Making in the Treatment of Older Adults Hospitalized for Acute Myocardial Infarction. Medical Decision Making 2020, 40: 279-288. PMID: 32428431, PMCID: PMC8684600, DOI: 10.1177/0272989x20912293.Peer-Reviewed Original ResearchConceptsST-elevated myocardial infarctionAcute myocardial infarctionMyocardial infarctionOlder adultsCardiologist's perspectiveOlder patientsSetting of AMIElevated myocardial infarctionPatient-specific riskConcept of SDMCardiologists' perceptionsMajor contraindicationPatient ageSuch patientsInterventional therapyFunctional limitationsInvasive proceduresPatientsInfarctionCognitive impairmentCardiologistsAdultsRiskConstant comparative methodTeam-based process
2019
Predicting 6-Month Mortality for Older Adults Hospitalized With Acute Myocardial Infarction: A Cohort Study.
Dodson JA, Hajduk AM, Geda M, Krumholz HM, Murphy TE, Tsang S, Tinetti ME, Nanna MG, McNamara R, Gill TM, Chaudhry SI. Predicting 6-Month Mortality for Older Adults Hospitalized With Acute Myocardial Infarction: A Cohort Study. Annals Of Internal Medicine 2019, 172: 12-21. PMID: 31816630, PMCID: PMC7695040, DOI: 10.7326/m19-0974.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPost-AMI mortalityFunctional impairmentOlder adultsCohort studyMean ageMyocardial infarctionPatient-reported health statusNet reclassification improvement indexProspective cohort studyParticipants' mean ageFinal risk modelMobility impairmentsGood discriminatory abilityRisk modelChart reviewHospital dischargePrognostic utilityBlood InstituteClinical variablesNational HeartHigh prevalenceHealth statusMortalityYounger counterpartsUsefulness of Social Support in Older Adults After Hospitalization for Acute Myocardial Infarction (from the SILVER-AMI Study)
Green YS, Hajduk AM, Song X, Krumholz HM, Sinha SK, Chaudhry SI. Usefulness of Social Support in Older Adults After Hospitalization for Acute Myocardial Infarction (from the SILVER-AMI Study). The American Journal Of Cardiology 2019, 125: 313-319. PMID: 31787249, PMCID: PMC7003680, DOI: 10.1016/j.amjcard.2019.10.038.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPost-AMI outcomesMyocardial infarctionIndependent associationMedical Outcomes Study Social Support SurveySocial supportOlder AMI patientsSocial Support SurveyParticipants 75 yearsLow emotional supportLow social supportImportant social determinantInitial hospitalizationOlder patientsDevelopment of interventionsAMI patientsMultivariable analysisMean ageMultivariable regressionHealth outcomesSupport SurveyInformational supportReadmissionSocial determinantsOlder adultsPatient-Reported Quality of Hospital Discharge Transitions: Results from the SILVER-AMI Study
Richards BG, Hajduk AM, Perry J, Krumholz HM, Khan AM, Chaudhry SI. Patient-Reported Quality of Hospital Discharge Transitions: Results from the SILVER-AMI Study. Journal Of General Internal Medicine 2019, 35: 808-814. PMID: 31654359, PMCID: PMC7080904, DOI: 10.1007/s11606-019-05414-8.Peer-Reviewed Original ResearchConceptsDays of dischargeEmergency department utilizationAcute myocardial infarctionPatient-reported qualityHospital discharge processOlder patientsAcute Myocardial Infarction StudyMyocardial Infarction StudyProspective cohort studyMedical record reviewEmergency room utilizationAdults age 75Key ResultsA totalHospital Consumer AssessmentSILVER-AMI StudyHospital discharge transitionsHigh-risk periodDesignMulti-centerCohort studyHospital dischargeMedian ageClinical outcomesRecord reviewAdverse outcomesResultsA totalAcute Kidney Injury Among Older Patients Undergoing Coronary Angiography for Acute Myocardial Infarction: The SILVER-AMI Study
Dodson JA, Hajduk A, Curtis J, Geda M, Krumholz HM, Song X, Tsang S, Blaum C, Miller P, Parikh CR, Chaudhry SI. Acute Kidney Injury Among Older Patients Undergoing Coronary Angiography for Acute Myocardial Infarction: The SILVER-AMI Study. The American Journal Of Medicine 2019, 132: e817-e826. PMID: 31170374, PMCID: PMC6891160, DOI: 10.1016/j.amjmed.2019.05.022.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAcute Kidney InjuryAge FactorsAgedAged, 80 and overCohort StudiesCoronary AngiographyDatabases, FactualFemaleGeriatric AssessmentHospital MortalityHospitalizationHumansKaplan-Meier EstimateLogistic ModelsMaleMyocardial InfarctionOdds RatioPrognosisProportional Hazards ModelsRisk AssessmentSeverity of Illness IndexSurvival AnalysisConceptsAcute kidney injuryAcute myocardial infarctionAge-related conditionsKidney injuryBody mass indexCoronary angiographyRisk factorsMyocardial infarctionOlder patientsMean ageAcute kidney injury risk factorsAcute Myocardial Infarction StudyAcute myocardial infarction cohortOlder adultsGlobal Outcomes criteriaMyocardial Infarction StudyInjury risk factorsParticipants' mean ageSILVER-AMI StudyMultivariable adjustmentComorbid diseasesHeart failureIndependent predictorsGeriatric conditionsMass indexThirty-Day Readmission Risk Model for Older Adults Hospitalized With Acute Myocardial Infarction
Dodson JA, Hajduk AM, Murphy TE, Geda M, Krumholz HM, Tsang S, Nanna MG, Tinetti ME, Goldstein D, Forman DE, Alexander KP, Gill TM, Chaudhry SI. Thirty-Day Readmission Risk Model for Older Adults Hospitalized With Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005320. PMID: 31010300, PMCID: PMC6481309, DOI: 10.1161/circoutcomes.118.005320.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overFemaleGeriatric AssessmentHealth Status IndicatorsHumansMaleMyocardial InfarctionPatient AdmissionPatient ReadmissionPredictive Value of TestsProspective StudiesReproducibility of ResultsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionReadmission risk modelFinal risk modelFunctional mobilityFunctional impairmentMyocardial infarctionOlder adultsFirst diastolic blood pressureChronic obstructive pulmonary diseaseAge-related functional impairmentsP2Y12 inhibitor useAcute kidney injuryDaily living (ADL) disabilityPatient-level factorsProspective cohort studyDiastolic blood pressureObstructive pulmonary diseasePatients of ageGeneral health statusStrongest predictorRisk modelMore comorbiditiesCause readmissionKidney injuryCohort study
2018
The Association of Frailty With In-Hospital Bleeding Among Older Adults With Acute Myocardial Infarction Insights From the ACTION Registry
Dodson JA, Hochman JS, Roe MT, Chen AY, Chaudhry SI, Katz S, Zhong H, Radford MJ, Udell J, Bagai A, Fonarow GC, Gulati M, Enriquez JR, Garratt KN, Alexander KP. The Association of Frailty With In-Hospital Bleeding Among Older Adults With Acute Myocardial Infarction Insights From the ACTION Registry. JACC Cardiovascular Interventions 2018, 11: 2287-2296. PMID: 30466828, PMCID: PMC6260951, DOI: 10.1016/j.jcin.2018.08.028.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overCardiac CatheterizationCognitionFemaleFrail ElderlyFrailtyGeriatric AssessmentHemorrhageHumansInpatientsMaleMobility LimitationMyocardial InfarctionPatient AdmissionPercutaneous Coronary InterventionRegistriesRisk AssessmentRisk FactorsTreatment OutcomeUnited StatesWalkingConceptsAssociation of frailtyAcute myocardial infarctionFrail patientsMajor bleedingCardiac catheterizationAMI patientsACTION RegistryAcute Myocardial Infarction—InsightsOlder adultsCategories of frailtyIn-Hospital BleedingNon-frail groupMultivariable logistic regressionYears of ageFrailty categoriesNonfrail patientsMyocardial infarctionIndependent associationCommon syndromeDaily livingHigh riskClinical strategiesPatientsBleedingFrailty
2017
Prehospital Delay in Older Adults with Acute Myocardial Infarction: The ComprehenSIVe Evaluation of Risk Factors in Older Patients with Acute Myocardial Infarction Study
Ouellet GM, Geda M, Murphy TE, Tsang S, Tinetti ME, Chaudhry SI. Prehospital Delay in Older Adults with Acute Myocardial Infarction: The ComprehenSIVe Evaluation of Risk Factors in Older Patients with Acute Myocardial Infarction Study. Journal Of The American Geriatrics Society 2017, 65: 2391-2396. PMID: 29044463, PMCID: PMC5681402, DOI: 10.1111/jgs.15102.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionAcute Myocardial Infarction StudyMyocardial Infarction StudyPrehospital delayOlder adultsOlder patientsHeart failureMyocardial infarctionRisk factorsFuture public health effortsContemporary national cohortMedical record abstractionPublic health effortsCross-sectional analysisAntiischemic therapyHospital presentationIndex hospitalizationHospital delaySymptom durationDiabetes mellitusClinical presentationComorbid conditionsRecord abstractionAtypical symptomsNonwhite race
2016
Slow Gait Speed and Risk of Mortality or Hospital Readmission After Myocardial Infarction in the Translational Research Investigating Underlying Disparities in Recovery from Acute Myocardial Infarction: Patients' Health Status Registry
Dodson JA, Arnold SV, Gosch KL, Gill TM, Spertus JA, Krumholz HM, Rich MW, Chaudhry SI, Forman DE, Masoudi FA, Alexander KP. Slow Gait Speed and Risk of Mortality or Hospital Readmission After Myocardial Infarction in the Translational Research Investigating Underlying Disparities in Recovery from Acute Myocardial Infarction: Patients' Health Status Registry. Journal Of The American Geriatrics Society 2016, 64: 596-601. PMID: 26926309, PMCID: PMC4803531, DOI: 10.1111/jgs.14016.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionSlow gaitHospital readmissionGait speedOlder adultsCox proportional hazards regressionMarker of frailtySlow gait speedTranslational researchProportional hazards regressionOutcomes 1 yearRisk of mortalityAssessment 1 monthBaseline characteristicsObservational cohortClinical factorsDiabetes mellitusHeart failureHazards regressionPrognostic importancePrognostic valueHigh prevalenceInfarctionReadmission