2020
Clinical Etiologies, Microbial Spectrum, Antibiotic Susceptibilities, and Visual Acuity Outcomes of Acute Endophthalmitis
Lu LJ, Chen X, Adelman RA. Clinical Etiologies, Microbial Spectrum, Antibiotic Susceptibilities, and Visual Acuity Outcomes of Acute Endophthalmitis. Journal Of Ocular Pharmacology And Therapeutics 2020, 36: 534-539. PMID: 32609038, DOI: 10.1089/jop.2018.0074.Peer-Reviewed Original ResearchConceptsVisual acuity outcomesClinical etiologyAntibiotic susceptibilityMicrobial spectrumAcute endophthalmitisAcuity outcomesPostoperative infectionCorneal ulcersCataract extractionEtiology of endophthalmitisFinal VA outcomesTertiary referral centerMajority of patientsRetrospective chart reviewICD-10 codesSpectrum of pathogensCommon inciting factorCulture-proven endophthalmitisChart reviewReferral centerVisual outcomeVA outcomesExogenous endophthalmitisClinical recordsMedical recordsFractal Dimension Analysis of Widefield Choroidal Vasculature as Predictor of Stage of Macular Degeneration
Young BK, Kovacs KD, Adelman RA. Fractal Dimension Analysis of Widefield Choroidal Vasculature as Predictor of Stage of Macular Degeneration. Translational Vision Science & Technology 2020, 9: 22-22. PMID: 32832228, PMCID: PMC7414655, DOI: 10.1167/tvst.9.7.22.Peer-Reviewed Original ResearchMeSH KeywordsChoroidFluorescein AngiographyFractalsHumansMacular DegenerationRetrospective StudiesUnited StatesThe new Myopic Traction Maculopathy Staging System
Parolini B, Palmieri M, Finzi A, Besozzi G, Lucente A, Nava U, Pinackatt S, Adelman R, Frisina R. The new Myopic Traction Maculopathy Staging System. European Journal Of Ophthalmology 2020, 31: 1299-1312. PMID: 32506945, DOI: 10.1177/1120672120930590.Peer-Reviewed Original ResearchVISUAL OUTCOME OF EARLY VITRECTOMY AND INTRAVITREAL ANTIBIOTICS IN ACUTE POSTSURGICAL AND POSTINTRAVITREAL INJECTION ENDOPHTHALMITIS: European Vitreo-Retinal Society Endophthalmitis Study Report Two.
Soliman MK, Gini G, Kuhn F, Parolini B, Ozdek S, Adelman RA, Sallam AB. VISUAL OUTCOME OF EARLY VITRECTOMY AND INTRAVITREAL ANTIBIOTICS IN ACUTE POSTSURGICAL AND POSTINTRAVITREAL INJECTION ENDOPHTHALMITIS: European Vitreo-Retinal Society Endophthalmitis Study Report Two. Retina 2020, 41: 423-430. PMID: 32467482, DOI: 10.1097/iae.0000000000002856.Peer-Reviewed Original ResearchConceptsIntravitreal antibioticsPPV groupEarly PPVVisual outcomeRetinal detachmentPostintravitreal injection endophthalmitisRetrospective multicenter cohortFinal visual acuityWeeks of presentationDays of presentationMethod of treatmentEarly vitrectomyMulticenter cohortIntravitreal injectionPlana vitrectomyRetina specialistsVisual acuityMean ageIntraocular proceduresEndophthalmitisSimilar outcomesLight perceptionEyesVitrectomyOutcomesManagement of vitreous floaters: an international survey the European VitreoRetinal Society Floaters study report
Zeydanli EO, Parolini B, Ozdek S, Bopp S, Adelman RA, Kuhn F, Gini G, Sallam AB, Aksakal N. Management of vitreous floaters: an international survey the European VitreoRetinal Society Floaters study report. Eye 2020, 34: 825-834. PMID: 32313173, PMCID: PMC7182575, DOI: 10.1038/s41433-020-0825-0.Peer-Reviewed Original ResearchMeSH KeywordsHumansPostoperative ComplicationsRetinal DetachmentRetinal PerforationsRetrospective StudiesVitrectomyVitreous BodyConceptsRelevant financial relationshipsFollowing relevant financial relationshipsRetrospective survey studyNovartis Pharmaceuticals CorporationAmerican Nurses Credentialing CenterSymptomatic floatersBoehringer Ingelheim PharmaceuticalsJournal CME author disclosure informationLaurie BarclayHeidelberg Pharma GmbHSpeakers bureauBayer AGAccreditation CouncilObjectivesUpon completionSurvey studySymptomatic improvementVitreous floatersSafety outcomesPatient careClinical implicationsHealthcare teamClinical researchAllerganMedscapePharmaceutical corporationsContinuing Medical Education
2019
International Practice Patterns for the Management of Acute Postsurgical and Postintravitreal Injection Endophthalmitis European Vitreo-Retinal Society Endophthalmitis Study Report 1
Soliman MK, Gini G, Kuhn F, Iros M, Parolini B, Ozdek S, Michalewska Z, Bopp S, Adelman RA, Sallam AB, Group E, Kardaszewska A, Zindamoyen A, Banker A, Serhiienko A, Loo A, Meireles A, Aydin B, Luebke B, Özmen C, Odrobina D, Bertelli E, Unsal E, Kenneth F, Becquet F, Hamon F, Pellegrini G, Tosi G, Donvito G, Khaqan H, Badat I, Fiser I, Michalewski J, Le Rouic J, Nawrocki J, Zarallo-Gallardo J, Lee J, Boninska K, Nowomiejska K, Dziegielewski K, Arrevola L, Lytvynchuk L, Elshafei M, Pietras-Trzpiel M, Irós M, Detjen M, Iglicki M, Badino M, Angelina M, Gavura M, Hasanreisoğlu M, Karadaş M, Atienza N, Acar N, Okonkwo O, Miesbauer P, Malgorzata P, Velez-Montoya R, Robert R, Frisina R, Soyeur R, Rejdak R, Giannini R, Mittal S, Saidkasimova S, Abdulsalam S, Cisiecki S, Rusnak S, Teoh S, Teixeira S, Altan T, Schrader W, Kapran Z, Aktas Z, Szijártó Z. International Practice Patterns for the Management of Acute Postsurgical and Postintravitreal Injection Endophthalmitis European Vitreo-Retinal Society Endophthalmitis Study Report 1. Ophthalmology Retina 2019, 3: 461-467. PMID: 31043364, DOI: 10.1016/j.oret.2019.03.009.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiogenesis InhibitorsAnti-Bacterial AgentsAntibiotic ProphylaxisCataract ExtractionDisease ManagementEndophthalmitisEuropeEye Infections, BacterialFemaleFollow-Up StudiesHumansIncidenceIntravitreal InjectionsMaleMiddle AgedOphthalmologyPractice Guidelines as TopicRetrospective StudiesSocieties, MedicalSurgical Wound InfectionVitrectomyConceptsEarly pars plana vitrectomyPars plana vitrectomyIntravitreal injectionIntravitreal antibioticsAcute endophthalmitisPlana vitrectomyIntraocular surgeryCataract surgeryPractice patternsAbsence of endophthalmitisSecond intravitreal injectionSecondary lens implantationProportion of eyesInternational practice patternsAcute postoperativeSystemic steroidsIntravitreal steroidsLens implantationAdjunctive therapySystemic antibioticsPostinjection endophthalmitisMulticenter studyRetina specialistsTherapeutic regimensVitreous opacification
2017
Vitrectomy in the management of diabetic macular edema in treatment-naïve patients
Michalewska Z, Stewart MW, Landers MB, Bednarski M, Adelman RA, Nawrocki J. Vitrectomy in the management of diabetic macular edema in treatment-naïve patients. Canadian Journal Of Ophthalmology 2017, 53: 402-407. PMID: 30119796, DOI: 10.1016/j.jcjo.2017.10.011.Peer-Reviewed Original ResearchConceptsTreatment-naïve diabetic macular edemaDiabetic macular edemaCentral retinal thicknessPars plana vitrectomyMacular edemaVisual acuityPlana vitrectomyMean central retinal thicknessDuration of diabetesProspective randomized trialsTreatment-naïve patientsInitial visual acuityVisual acuity changesPrimary outcome measureEfficacy of vitrectomyElectronic medical recordsEarly vitrectomyIntravitreal bevacizumabFinal BCVAMean BCVAPrimary endpointRetinal thicknessConsecutive patientsRandomized trialsRetrospective studyASSOCIATION BETWEEN THE VITREOMACULAR INTERFACE AND OPTICAL COHERENCE TOMOGRAPHY CHARACTERISTICS IN WET AGE-RELATED MACULAR DEGENERATION
Ashraf M, Souka A, Adelman RA. ASSOCIATION BETWEEN THE VITREOMACULAR INTERFACE AND OPTICAL COHERENCE TOMOGRAPHY CHARACTERISTICS IN WET AGE-RELATED MACULAR DEGENERATION. Retina 2017, 37: 1738-1745. PMID: 28005632, DOI: 10.1097/iae.0000000000001423.Peer-Reviewed Original ResearchConceptsType 1 choroidal neovascularizationChoroidal thicknessChoroidal neovascularizationWet AMDVitreomacular adhesionDry AMDVitreomacular interfaceMacular degenerationRetrospective observational cross-sectional studyOptical coherence tomography examinationObservational cross-sectional studyAge-related macular degenerationType of CNVPaired-eye studyMean choroidal thicknessCross-sectional studySignificant differencesOptical coherence tomographyWet AgeSubgroup analysisTomography examinationHeidelberg SpectralisPatientsCoherence tomographyDegeneration characteristic
2016
Trends of Anti-Vascular Endothelial Growth Factor Use in Ophthalmology Among Privately Insured and Medicare Advantage Patients
Parikh R, Ross JS, Sangaralingham LR, Adelman RA, Shah ND, Barkmeier AJ. Trends of Anti-Vascular Endothelial Growth Factor Use in Ophthalmology Among Privately Insured and Medicare Advantage Patients. Ophthalmology 2016, 124: 352-358. PMID: 27890437, DOI: 10.1016/j.ophtha.2016.10.036.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngiogenesis InhibitorsBevacizumabCohort StudiesDatabases, FactualDiabetic RetinopathyDrug UtilizationFemaleHumansInsurance, HealthIntravitreal InjectionsMacular DegenerationMaleMedicare Part CMiddle AgedOphthalmologyPrivate SectorRanibizumabReceptors, Vascular Endothelial Growth FactorRecombinant Fusion ProteinsRetinal Vein OcclusionRetrospective StudiesUnited StatesVascular Endothelial Growth Factor AYoung AdultConceptsAge-related macular degenerationDiabetic retinal diseaseAnti-VEGF injectionsIntravitreal anti-VEGF injectionsRetinal vein occlusionAdministrative claims dataRetinal diseasesOphthalmic diseasesVein occlusionClaims dataUse of bevacizumabCurrent Procedural Terminology codesPatients 18 yearsRetrospective cohort studyMedicare Advantage patientsOptumLabs Data WarehouseDrug Administration approvalProcedural Terminology codesGrowth factor useRanibizumab useBevacizumab useAvailable medicationsCohort studyMedication useCommon medications
2014
Aflibercept in the Treatment of Neovascular Age-Related Macular Degeneration in Previously Treated Patients
Hall LB, Zebardast N, Huang JJ, Adelman RA. Aflibercept in the Treatment of Neovascular Age-Related Macular Degeneration in Previously Treated Patients. Journal Of Ocular Pharmacology And Therapeutics 2014, 30: 346-352. PMID: 24552305, DOI: 10.1089/jop.2013.0188.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAntibodies, Monoclonal, HumanizedBevacizumabFemaleHumansIntravitreal InjectionsMacular DegenerationMaleRanibizumabReceptors, Vascular Endothelial Growth FactorRecombinant Fusion ProteinsRetinaRetrospective StudiesTomography, Optical CoherenceTreatment OutcomeVascular Endothelial Growth Factor AVisual AcuityConceptsAge-related macular degenerationCentral macular thicknessAflibercept injectionsInitial visitMacular degenerationAnti-vascular endothelial growth factor treatmentNeovascular age-related macular degenerationEndothelial growth factor treatmentCentral macular edemaIntraocular pressure increaseSubset of patientsMain outcome measuresOptical coherence tomographyGrowth factor treatmentMacular thicknessNeovascular AgeOcular hypertensionSubmacular fluidVisual outcomeMacular edemaRetrospective studyVisual acuityOutcome measuresStudy populationPatients
2013
Strategy for the Management of Complex Retinal Detachments The European Vitreo-Retinal Society Retinal Detachment Study Report 2
Adelman RA, Parnes AJ, Sipperley JO, Ducournau D, Group E. Strategy for the Management of Complex Retinal Detachments The European Vitreo-Retinal Society Retinal Detachment Study Report 2. Ophthalmology 2013, 120: 1809-1813. PMID: 23601805, DOI: 10.1016/j.ophtha.2013.01.056.Peer-Reviewed Original ResearchConceptsRhegmatogenous retinal detachmentGiant retinal tearsRetinal detachmentScleral buckleComplex retinal detachmentChoroidal detachmentRetinal tearsGrade CGrade B proliferative vitreoretinopathyLow failure rateComplex rhegmatogenous retinal detachmentRetinal detachment repairFailure rateProcedure of choiceSignificant differencesMethod of repairSignificant hypotonyClinical manifestationsDetachment repairGiant tearsRetrospective studyMacular holePrimary procedureProliferative vitreoretinopathyLarge tearsStrategy for the Management of Uncomplicated Retinal Detachments The European Vitreo-Retinal Society Retinal Detachment Study Report 1
Adelman RA, Parnes AJ, Ducournau D, Group E. Strategy for the Management of Uncomplicated Retinal Detachments The European Vitreo-Retinal Society Retinal Detachment Study Report 1. Ophthalmology 2013, 120: 1804-1808. PMID: 23601799, DOI: 10.1016/j.ophtha.2013.01.070.Peer-Reviewed Original ResearchConceptsRhegmatogenous retinal detachmentUncomplicated rhegmatogenous retinal detachmentScleral buckle groupRetinal detachmentScleral buckleFinal failure rateSingle-surgery reattachment rateCases of RRDBenefit of vitrectomyMulticenter retrospective studyRetinal detachment repairUncomplicated retinal detachmentsSpecific clinical findingsFailure ratePhakic retinal detachmentSignificant differencesMethod of repairAphakic groupPhakic patientsVitrectomy groupUncomplicated casesClinical findingsDetachment repairPseudophakic patientsReattachment rate
2012
ACUTE SYPHILITIC POSTERIOR PLACOID CHORIORETINITIS
Eandi CM, Neri P, Adelman RA, Yannuzzi LA, Cunningham ET. ACUTE SYPHILITIC POSTERIOR PLACOID CHORIORETINITIS. Retina 2012, 32: 1915-1941. PMID: 22863970, DOI: 10.1097/iae.0b013e31825f3851.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAnti-Bacterial AgentsCD4 Lymphocyte CountChorioretinitisColoring AgentsDrug Therapy, CombinationEye Infections, BacterialFemaleFluorescein AngiographyFluorescent Treponemal Antibody-Absorption TestGlucocorticoidsHIV SeropositivityHumansIndocyanine GreenInfusions, IntravenousMaleMiddle AgedPenicillin GRetrospective StudiesSyphilisTomography, Optical CoherenceVisual AcuityConceptsAcute syphilitic posterior placoid chorioretinitisPosterior placoid chorioretinitisCD4 cell countCells/μLAntibiotic therapyAngiographic featuresFluorescein angiographyPositive venereal disease research laboratoryCell countHuman immunodeficiency virus (HIV) coinfectionMedian CD4 cell countRapid plasma regain titerRecent CD4 cell countVenereal Disease Research LaboratoryFluorescent treponemal antibody absorptionEvidence of neurosyphilisMulticenter chart reviewOuter retinal lesionsImmunodeficiency virus coinfectionAppropriate antibiotic therapyPosterior segment examinationSeries of patientsHuman immunodeficiency virusPositive serologic testsRed-free photographsMicrobial Spectrum and Resistance Patterns in Endophthalmitis: A 21-Year (1988–2008) Review in Northeast United States
Chen X, Adelman RA. Microbial Spectrum and Resistance Patterns in Endophthalmitis: A 21-Year (1988–2008) Review in Northeast United States. Journal Of Ocular Pharmacology And Therapeutics 2012, 28: 329-334. PMID: 22506856, DOI: 10.1089/jop.2011.0204.Peer-Reviewed Original ResearchIs Intravitreal Bevacizumab an Effective Treatment Option for Nonarteritic Anterior Ischemic Optic Neuropathy?
Prescott CR, Sklar CA, Lesser RL, Adelman RA. Is Intravitreal Bevacizumab an Effective Treatment Option for Nonarteritic Anterior Ischemic Optic Neuropathy? Journal Of Neuro-Ophthalmology 2012, 32: 51-53. PMID: 22269947, DOI: 10.1097/wno.0b013e318240596e.Peer-Reviewed Original ResearchConceptsNonarteritic anterior ischemic optic neuropathyAnterior ischemic optic neuropathyIschemic optic neuropathyVisual acuityIntravitreal bevacizumabOptic neuropathyTreatment optionsIntravitreal bevacizumab injectionEffective treatment optionVisual field defectsBevacizumab injectionFellow eyesClinical outcomesRetrospective studyTreatment modalitiesNatural courseField defectsPatientsDecreased acuitySmall seriesAcuityBevacizumabProfound lossVisual fieldNeuropathy
2011
The Treatment of Recurrent Central Serous Chorioretinopathy with Intravitreal Bevacizumab
Lee ST, Adelman RA. The Treatment of Recurrent Central Serous Chorioretinopathy with Intravitreal Bevacizumab. Journal Of Ocular Pharmacology And Therapeutics 2011, 27: 611-614. PMID: 21810026, DOI: 10.1089/jop.2011.0045.Peer-Reviewed Original ResearchConceptsRecurrent central serous chorioretinopathyMean central macular thicknessCentral macular thicknessCentral serous chorioretinopathyPreinjection visual acuityVisual acuityOptical coherence tomographyIntravitreal bevacizumabSerous chorioretinopathyTreatment optionsLow-risk treatment optionYale Eye CenterIntravitreal bevacizumab injectionRetrospective case seriesEffective treatment optionLong-term efficacySub-retinal fluidNumber of injectionsFluorescein angiography imagingBevacizumab injectionRecurrent diseaseMacular thicknessMonth 3Month 6Case series
2010
Persistent Ocular Hypertension Following Intravitreal Bevacizumab and Ranibizumab Injections
Adelman RA, Zheng Q, Mayer HR. Persistent Ocular Hypertension Following Intravitreal Bevacizumab and Ranibizumab Injections. Journal Of Ocular Pharmacology And Therapeutics 2010, 26: 105-110. PMID: 20187807, DOI: 10.1089/jop.2009.0076.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBevacizumabDrug Administration ScheduleDrug Therapy, CombinationFemaleHumansInjections, IntraocularIntraocular PressureMacular DegenerationMaleOcular HypertensionRanibizumabRetrospective StudiesTime FactorsVascular Endothelial Growth Factor AVitreous BodyConceptsAge-related macular degenerationPersistent ocular hypertensionOcular hypertensionIntraocular pressureIntravitreal bevacizumabRanibizumab injectionsIntravitreal injectionPrevious diagnosisGlaucoma/ocular hypertensionIntravitreal anti-VEGF injectionsAnti-VEGF injectionsIntravitreal bevacizumab injectionPostinjection intraocular pressurePreinjection intraocular pressureMultiple intravitreal injectionsTertiary referral centerRetrospective case seriesElevated intraocular pressureBevacizumab injectionIntravitreal ranibizumabReferral centerCase seriesVEGF injectionIOP increaseYAG capsulotomy
2009
ASSESSMENT OF OPTIC NERVE CUP-TO-DISK RATIO CHANGES IN PATIENTS RECEIVING MULTIPLE INTRAVITREAL INJECTIONS OF ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR AGENTS
SETH RK, SALIM S, SHIELDS MB, ADELMAN RA. ASSESSMENT OF OPTIC NERVE CUP-TO-DISK RATIO CHANGES IN PATIENTS RECEIVING MULTIPLE INTRAVITREAL INJECTIONS OF ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR AGENTS. Retina 2009, 29: 956-959. PMID: 19584654, DOI: 10.1097/iae.0b013e3181a91dfd.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAptamers, NucleotideDrug Therapy, CombinationEyeFollow-Up StudiesFundus OculiHumansInjectionsIntraocular PressureOptic DiskOptic NerveRanibizumabRegional Blood FlowRetrospective StudiesSingle-Blind MethodVascular Endothelial Growth Factor AVitreous BodyConceptsMultiple intravitreal injectionsAnti-VEGF agentsIntraocular pressure riseIntraocular pressure fluctuationIntravitreal injectionMean changeControl groupTransient intraocular pressure riseSignificant differencesDisc ratio changesOptic nerve cupHistory of glaucomaAdditional prospective studiesGrowth factor effectsFellow eyesGlaucoma specialistsOptic nerveProspective studyOptic disc imagesFundus photographsTriamcinolone acetonideInclusion criteriaDisc ratioVertical cupPatients
2008
Ocular trauma resulting from paintball injury
Pahk PJ, Adelman RA. Ocular trauma resulting from paintball injury. Graefe's Archive For Clinical And Experimental Ophthalmology 2008, 247: 469. PMID: 19034480, DOI: 10.1007/s00417-008-0985-2.Peer-Reviewed Original ResearchConceptsProper eye protectionIntraocular foreign bodyOcular injuriesLoss of visionVisual acuityPaintball injuriesProliferative vitreoretinopathyEye protectionSignificant ocular injuryFinal visual acuitySevere ocular injuryTertiary referral centerSubluxation of lensLens injuryMethodsRetrospective reviewSecondary glaucomaCommotio retinaeOcular traumaReferral centerEye injuriesRetinal hemorrhagesVitreous hemorrhageChoroidal ruptureIris injuryRetinal tearsPredicting Response to Glaucoma Therapy in One Eye Based on Response in the Fellow Eye: The Monocular Trial
Chaudhary O, Adelman RA, Shields MB. Predicting Response to Glaucoma Therapy in One Eye Based on Response in the Fellow Eye: The Monocular Trial. JAMA Ophthalmology 2008, 126: 1216-1220. PMID: 18779480, DOI: 10.1001/archopht.126.9.1216.Peer-Reviewed Original ResearchConceptsPrimary open-angle glaucomaIntraocular pressureFellow eyesGlaucoma suspectsSecond eyeFirst eyeSame medicationRetrospective medical record reviewTrue therapeutic effectMedical record reviewOpen-angle glaucomaMedication regimenRecord reviewGlaucoma therapyTherapeutic effectDrug trialsBinocular treatmentMonocular trialMedicationsPatientsAbsolute changeEyesSubsequent responseFurther studiesTrials