2024
Retinal integrity in human babesiosis: a pilot study
Dionne E, Adelman R, Cekic O, Golden M, Moffarah A, Krause P, Farhadian S. Retinal integrity in human babesiosis: a pilot study. BMC Ophthalmology 2024, 24: 310. PMID: 39048971, PMCID: PMC11267664, DOI: 10.1186/s12886-024-03568-6.Peer-Reviewed Original ResearchConceptsEvidence of retinopathyNo study patientRetina of patientsCohort of patientsAbnormal vessel formationComplication of babesiosisRetinal tearsRetinal inflammationRetinal eye examResultsTen patientsRetinal integrityRetinal examinationRetinal bleedingIndirect ophthalmoscopeRetinal abnormalitiesStudy patientsChart reviewCase reportEye examPilot studyPatientsAnimal studiesSmall studyClinical informationHuman babesiosis
2019
Panretinal Photocoagulation along the Long Ciliary Nerve in Diabetic Retinopathy
Lu AJ, Freedman IG, Shakir O, Adelman RA, Del Priore LV. Panretinal Photocoagulation along the Long Ciliary Nerve in Diabetic Retinopathy. Ophthalmology Retina 2019, 3: 1105-1107. PMID: 31519540, DOI: 10.1016/j.oret.2019.07.002.Peer-Reviewed Original ResearchDisease-associated mutations of claudin-19 disrupt retinal neurogenesis and visual function
Wang SB, Xu T, Peng S, Singh D, Ghiassi-Nejad M, Adelman RA, Rizzolo LJ. Disease-associated mutations of claudin-19 disrupt retinal neurogenesis and visual function. Communications Biology 2019, 2: 113. PMID: 30937396, PMCID: PMC6433901, DOI: 10.1038/s42003-019-0355-0.Peer-Reviewed Original ResearchConceptsRetinal pigment epitheliumClaudin-19Retinal neurogenesisP1 waveOuter nuclear layerRPE signature genesARPE19 cell lineOcular involvementKidney diseaseVisual functionFamilial hypomagnesaemiaNuclear layerBipolar cellsNewborn miceOcular diseasesPigment epitheliumRetinal isomeraseDiseaseMiceHuman induced pluripotent cellsRetinal differentiationSignature genesCell linesNeurogenesisInduced pluripotent cells
2017
A biodegradable scaffold enhances differentiation of embryonic stem cells into a thick sheet of retinal cells
Singh D, Wang SB, Xia T, Tainsh L, Ghiassi-Nejad M, Xu T, Peng S, Adelman RA, Rizzolo LJ. A biodegradable scaffold enhances differentiation of embryonic stem cells into a thick sheet of retinal cells. Biomaterials 2017, 154: 158-168. PMID: 29128844, DOI: 10.1016/j.biomaterials.2017.10.052.Peer-Reviewed Original ResearchConceptsRetinal degenerationNeurosensory retinaRetinal cellsHost retinal pigment epitheliumStem cellsOuter nuclear layerRetinal pigment epitheliumRetinal cell typesElaborate arborsQuantitative RT-PCRLeading causeImmune responseNuclear layerMouse modelPigment epitheliumSubretinal spaceForebrain cellsMinimal immune responseTherapeutic agentsRetinal laminationRT-PCRDegenerationRetinaRetinal organoidsConfocal immunocytochemistry
2015
New Approaches, Findings, and Diagnostics in Medical and Surgical Retina
Nawrocki J, Adelman R, Ducournau D. New Approaches, Findings, and Diagnostics in Medical and Surgical Retina. BioMed Research International 2015, 2015: 193561. PMID: 25705650, PMCID: PMC4325221, DOI: 10.1155/2015/193561.Peer-Reviewed Original ResearchStrategy for the Management of Diabetic Macular Edema: The European Vitreo‐Retinal Society Macular Edema Study
Adelman R, Parnes A, Michalewska Z, Parolini B, Boscher C, Ducournau D. Strategy for the Management of Diabetic Macular Edema: The European Vitreo‐Retinal Society Macular Edema Study. BioMed Research International 2015, 2015: 352487. PMID: 25695062, PMCID: PMC4324105, DOI: 10.1155/2015/352487.Peer-Reviewed Original ResearchConceptsDiabetic macular edemaMacular edemaVisual acuityVisual improvementBetter visual improvementMulticenter clinical studyPars plana vitrectomySignificant visual improvementEdema studyTriamcinolone monotherapyVEGF therapyVEGF injectionVision gainClinical findingsGrid laserPlana vitrectomyRetina specialistsClinical studiesDifferent therapiesClinical informationEdemaAcuityTherapyMean numberTreatment
2014
Angiophagy Prevents Early Embolus Washout But Recanalizes Microvessels Through Embolus Extravasation
Grutzendler J, Murikinati S, Hiner B, Ji L, Lam CK, Yoo T, Gupta S, Hafler BP, Adelman RA, Yuan P, Rodriguez G. Angiophagy Prevents Early Embolus Washout But Recanalizes Microvessels Through Embolus Extravasation. Science Translational Medicine 2014, 6: 226ra31. PMID: 24598589, DOI: 10.1126/scitranslmed.3006585.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCerebrovascular CirculationCoronary CirculationEmbolismFibrinFibrinolysisFundus OculiGreen Fluorescent ProteinsHemodynamicsHumansKidney TubulesLungMacrophagesMiceMice, TransgenicMicrocirculationMicrogliaMicroscopy, Electron, TransmissionMicrovesselsMonocytesPhagocytosisRetinaRetinal VesselsThrombosisConceptsBlood flow reestablishmentHours of occlusionVascular occlusive disordersDifferent therapeutic strategiesEmbolic occlusionOcclusive disordersVessel recanalizationAlveolar spaceTherapeutic strategiesTherapeutic targetHemodynamic pressureFibrinolytic systemPerivascular spacesEmboliRenal tubulesBlood clotsMicrovascular wallMost human organsOcclusionLungExtravasationKidneyEndotheliumMicrovasculatureWashoutAflibercept in the Treatment of Neovascular Age-Related Macular Degeneration in Previously Treated Patients
Hall LB, Zebardast N, Huang JJ, Adelman RA. Aflibercept in the Treatment of Neovascular Age-Related Macular Degeneration in Previously Treated Patients. Journal Of Ocular Pharmacology And Therapeutics 2014, 30: 346-352. PMID: 24552305, DOI: 10.1089/jop.2013.0188.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAntibodies, Monoclonal, HumanizedBevacizumabFemaleHumansIntravitreal InjectionsMacular DegenerationMaleRanibizumabReceptors, Vascular Endothelial Growth FactorRecombinant Fusion ProteinsRetinaRetrospective StudiesTomography, Optical CoherenceTreatment OutcomeVascular Endothelial Growth Factor AVisual AcuityConceptsAge-related macular degenerationCentral macular thicknessAflibercept injectionsInitial visitMacular degenerationAnti-vascular endothelial growth factor treatmentNeovascular age-related macular degenerationEndothelial growth factor treatmentCentral macular edemaIntraocular pressure increaseSubset of patientsMain outcome measuresOptical coherence tomographyGrowth factor treatmentMacular thicknessNeovascular AgeOcular hypertensionSubmacular fluidVisual outcomeMacular edemaRetrospective studyVisual acuityOutcome measuresStudy populationPatients
2009
A study of macular hole formation by serial spectral optical coherence tomography
Michalewska Z, Michalewski J, Sikorski BL, Kałużny J, Wojtkowski M, Adelman RA, Nawrocki J. A study of macular hole formation by serial spectral optical coherence tomography. Clinical And Experimental Ophthalmology 2009, 37: 373-383. PMID: 19594564, DOI: 10.1111/j.1442-9071.2009.02041.x.Peer-Reviewed Original Research
2006
Surgical Management of Pseudophakic Retinal Detachments A Meta-analysis
Arya AV, Emerson JW, Engelbert M, Hagedorn CL, Adelman RA. Surgical Management of Pseudophakic Retinal Detachments A Meta-analysis. Ophthalmology 2006, 113: 1724-1733. PMID: 17011954, DOI: 10.1016/j.ophtha.2006.05.044.Peer-Reviewed Original ResearchConceptsPseudophakic retinal detachmentPars plana vitrectomyUncomplicated pseudophakic retinal detachmentsFinal visual outcomeRetinal detachmentFunctional success rateScleral buckleVisual outcomeSurgical interventionPrimary failureSuccess rateStudy characteristicsInitial reattachment rateAnatomical success rateInitial surgical interventionPrimary surgical interventionCross-reference searchPreoperative evaluationSurgical managementSurgical treatmentPlana vitrectomyPneumatic retinopexyReattachment ratePooled analysisStudy protocol
2004
Bilateral intraocular foreign bodies simulating crystalline lens
Hagedorn CL, Tauber S, Adelman RA. Bilateral intraocular foreign bodies simulating crystalline lens. American Journal Of Ophthalmology 2004, 138: 146-147. PMID: 15234299, DOI: 10.1016/j.ajo.2004.01.046.Peer-Reviewed Original ResearchConceptsIntraocular foreign bodyForeign bodyCrystalline lensRight eyeCT scanComputed tomographyOpen globe repairRetinal detachment surgeryMotor vehicle accidentsGlobe repairDetachment surgeryPlana vitrectomyCase reportCataract extractionMissile injuriesCorneal graftingVehicle accidentsPatientsHigh radiodensityScansEyesPiece of glassVitrectomyLacerationSurgery