2024
Artificial intelligence-guided screening of under-recognized cardiomyopathies adapted for point-of-care echocardiography
Oikonomou E, Holste G, Coppi A, Mcnamara R, Nadkarni G, Krumholz H, Wang Z, Miller E, Khera R. Artificial intelligence-guided screening of under-recognized cardiomyopathies adapted for point-of-care echocardiography. European Heart Journal 2024, 45: ehae666.157. DOI: 10.1093/eurheartj/ehae666.157.Peer-Reviewed Original ResearchConvolutional neural networkMulti-labelState-of-the-art performanceState-of-the-artCustom loss functionDeep learning modelsAI frameworkNeural networkLoss functionAutomated metricsLearning modelsAugmentation approachVideoAcquisition qualityAdvanced protocolsPoint-of-care ultrasonographyImagesTransthoracic echocardiogramClassifierATTR-CMAlgorithmNetworkAI screeningAcquisitionPresence of severe ASResidual Ultrasound-Enhancing Agents Mimicking Portal Venous Gas
Bitar R, Langdon J, Kaur M, Crandall I, McNamara R, Revzin M. Residual Ultrasound-Enhancing Agents Mimicking Portal Venous Gas. Ultrasound Quarterly 2024, 40: e00694. PMID: 39466239, DOI: 10.1097/ruq.0000000000000694.Peer-Reviewed Original ResearchConceptsUltrasound enhancing agentsPortal venous gasBowel ischemiaAbdominal ultrasoundVenous gasEchogenic fociContrast-enhanced echocardiographyEvaluation of cardiac functionPortal venous systemSeries of casesSonographic detectionCardiac functionDifferential diagnosisPortal veinVenous systemObservational studyLiver parenchymaPortal triadsVascular patencyBowelIschemiaEchocardiographyLiverUltrasoundA Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression
Oikonomou E, Holste G, Yuan N, Coppi A, McNamara R, Haynes N, Vora A, Velazquez E, Li F, Menon V, Kapadia S, Gill T, Nadkarni G, Krumholz H, Wang Z, Ouyang D, Khera R. A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression. JAMA Cardiology 2024, 9: 534-544. PMID: 38581644, PMCID: PMC10999005, DOI: 10.1001/jamacardio.2024.0595.Peer-Reviewed Original ResearchCardiac magnetic resonanceAortic valve replacementCardiac magnetic resonance imagingAV VmaxSevere ASAortic stenosisCohort studyPeak aortic valve velocityCohort study of patientsAortic valve velocityCohort of patientsTraditional cardiovascular risk factorsAssociated with faster progressionStudy of patientsCedars-Sinai Medical CenterAssociated with AS developmentCardiovascular risk factorsCardiovascular imaging modalitiesIndependent of ageModerate ASEjection fractionEchocardiographic studiesValve replacementRisk stratificationCardiac structureHigh- versus low-gradient aortic stenosis: Is our evaluation limited by aorto-mitral angle on cardiovascular CT?
See C, Kim Y, Park J, Wang Y, Reinhardt S, Shkolnik E, Faridi K, Lombo B, Bellumkonda L, McNamara R, Sugeng L, Hur D. High- versus low-gradient aortic stenosis: Is our evaluation limited by aorto-mitral angle on cardiovascular CT? International Journal Of Cardiology 2024, 409: 132174. PMID: 38754590, DOI: 10.1016/j.ijcard.2024.132174.Peer-Reviewed Original ResearchNormal-flow low-gradientAortic valve areaTranscatheter AV replacementParadoxical low-flow low-gradientCardiovascular CTTransthoracic echocardiogramCalcium scoreAS patientsDiagnosis of severe ASLow-gradient aortic stenosisHG-AS patientsLG-AS patientsLow-flow low-gradientAorto-mitral angleAortic valve (AV) stenosisLG-ASPLFLG-ASAV replacementSevere ASConsecutive patientsAortic stenosisValve areaAS phenotypeClinical managementEchocardiogramUltrasound evaluation of portal venous gas and its mimics
Bitar R, Kaur M, Crandall I, McNamara R, Revzin M. Ultrasound evaluation of portal venous gas and its mimics. Abdominal Radiology 2024, 49: 2756-2769. PMID: 38735019, DOI: 10.1007/s00261-024-04328-2.Peer-Reviewed Original ResearchFactors associated with reporting left ventricular ejection fraction with 3D echocardiography in real‐world practice
Faridi K, Zhu Z, Shah N, Crandall I, McNamara R, Flueckiger P, Bachand K, Lombo B, Hur D, Agarwal V, Reinhardt S, Velazquez E, Sugeng L. Factors associated with reporting left ventricular ejection fraction with 3D echocardiography in real‐world practice. Echocardiography 2024, 41: e15774. PMID: 38329886, DOI: 10.1111/echo.15774.Peer-Reviewed Original ResearchConceptsTransthoracic echocardiogramVentricular ejection fractionOutpatient transthoracic echocardiogramsReal-world practiceEjection fractionLeft ventricular ejection fractionAssess left ventricular ejection fractionInpatient transthoracic echocardiogramsMultivariate logistic regressionLVEFHospitalized patientsMedical CenterSonographersClinical settingLogistic regressionUltrasound machineChemotherapyContrast enhancement agentsPortable studiesNegative association
2023
Variation in Reader-Reported Severity of Paradoxical Low-Flow Low-Gradient Aortic Stenosis
Shah N, Sugeng L, Zhang Z, Wang K, McNamara R, Agarwal V, Hur D, Lombo B, Bellumkonda L, Mankbadi M, Basem Dajani A, Forrest J, Krumholz H, Reinhardt S, Velazquez E, Faridi K. Variation in Reader-Reported Severity of Paradoxical Low-Flow Low-Gradient Aortic Stenosis. Journal Of The American Society Of Echocardiography 2023, 37: 466-467. PMID: 37995937, DOI: 10.1016/j.echo.2023.11.014.Peer-Reviewed Original ResearchPredicting aortic stenosis progression using a video-based deep learning model of aortic stenosis built for single-view two-dimensional echocardiography
Oikonomou E, Holste G, Mcnamara R, Velazquez E, Nadkarni G, Ouyang D, Krumholz H, Wang Z, Khera R. Predicting aortic stenosis progression using a video-based deep learning model of aortic stenosis built for single-view two-dimensional echocardiography. European Heart Journal 2023, 44: ehad655.040. DOI: 10.1093/eurheartj/ehad655.040.Peer-Reviewed Original ResearchLeft ventricular ejection fractionSevere aortic stenosisAortic stenosisAS progressionAV VmaxTransthoracic echocardiographyYale New Haven Health SystemBaseline left ventricular ejection fractionAortic stenosis progressionModerate aortic stenosisRetrospective cohort studyVentricular ejection fractionTwo-dimensional echocardiographyMean rateModerate ASAS severityCohort studyEjection fractionPatient sexStenosis progressionTTE studiesEligible participantsSerial monitoringSpecialized centersTimely diagnosisSevere aortic stenosis detection by deep learning applied to echocardiography
Holste G, Oikonomou E, Mortazavi B, Coppi A, Faridi K, Miller E, Forrest J, McNamara R, Ohno-Machado L, Yuan N, Gupta A, Ouyang D, Krumholz H, Wang Z, Khera R. Severe aortic stenosis detection by deep learning applied to echocardiography. European Heart Journal 2023, 44: 4592-4604. PMID: 37611002, PMCID: PMC11004929, DOI: 10.1093/eurheartj/ehad456.Peer-Reviewed Original ResearchTHE INCIDENCE OF CHAGAS CARDIOMYOPATHY IN A NORTHWESTERN COMMUNITY OF CÓRDOBA, ARGENTINA
Martinez M, Amuchastegui M, Grima J, Amuchastegui T, Alvarellos T, McNamara K, Garimella S, Sánchez A, Mankbadi M, Sewanan L, Salomone O, McNamara R, Lombo B. THE INCIDENCE OF CHAGAS CARDIOMYOPATHY IN A NORTHWESTERN COMMUNITY OF CÓRDOBA, ARGENTINA. Journal Of The American College Of Cardiology 2023, 81: 553. DOI: 10.1016/s0735-1097(23)00997-x.Peer-Reviewed Original Research
2022
Abnormal left atrial body stiffness is predicted by appendage size: impact of appendage occlusion on left atrial mechanics assessed by pressure-volume analysis
Bregasi A, Freeman JV, Curtis JP, Akar JG, Ortiz-Leon XA, Maia JH, Higgins AY, Matthews RV, Sinusas AJ, McNamara RL, Sugeng L, Lin BA. Abnormal left atrial body stiffness is predicted by appendage size: impact of appendage occlusion on left atrial mechanics assessed by pressure-volume analysis. AJP Heart And Circulatory Physiology 2022, 323: h559-h568. PMID: 35960632, PMCID: PMC9576173, DOI: 10.1152/ajpheart.00083.2022.Peer-Reviewed Original ResearchConceptsLeft atrial appendage occlusionLA stiffnessAppendage occlusionLA appendageLA mechanicsTransesophageal echocardiographyPressure-volume analysisPercutaneous left atrial appendage occlusionAdverse atrial remodelingAtrial appendage occlusionLeft atrial appendageLA volume measurementsAtrial cardiomyopathyBaseline characteristicsLA complianceAtrial remodelingClinical outcomesAtrial appendageAtrial mechanicsCardiac performancePathophysiological roleBaseline parametersMagnitude of increaseAppendage sizeOcclusion
2021
IN-HOSPITAL MORTALITY RISK PREDICTION FOR PERCUTANEOUS CORONARY INTERVENTIONS: AN UPDATED MODEL FROM THE NCDR CATHPCI REGISTRY
Dominguez Y, Minges K, Wang Y, McNamara R, Spertus J, Dehmer G, Messenger J, Mercado N, Lavin K, Pierre D, Anderson C, Blankinship K, Clary J, Osborne A, Curtis J, Cavender M. IN-HOSPITAL MORTALITY RISK PREDICTION FOR PERCUTANEOUS CORONARY INTERVENTIONS: AN UPDATED MODEL FROM THE NCDR CATHPCI REGISTRY. Journal Of The American College Of Cardiology 2021, 77: 1217. DOI: 10.1016/s0735-1097(21)02576-6.Peer-Reviewed Original Research
2020
2020 Update to the 2016 ACC/AHA Clinical Performance and Quality Measures for Adults With Atrial Fibrillation or Atrial Flutter: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures
Members W, Heidenreich P, Estes N, Fonarow G, Jurgens C, Kittleson M, Marine J, McManus D, McNamara R. 2020 Update to the 2016 ACC/AHA Clinical Performance and Quality Measures for Adults With Atrial Fibrillation or Atrial Flutter: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. Circulation Cardiovascular Quality And Outcomes 2020, 14: e000100. PMID: 33284642, DOI: 10.1161/hcq.0000000000000100.Peer-Reviewed Original ResearchTRICUSPID AND MITRAL REMODELING IN ATRIAL FIBRILLATION: A THREE-DIMENSIONAL ECHOCARDIOGRAPHIC STUDY
Ortiz-Leon X, Posada E, Trejo M, Miranda J, Pereira J, Crandall I, DaSilva P, Bouman E, Brooks A, Gerardi C, Houle H, Akar J, Lin B, McNamara R, Lombo B, Arias-Godínez J, Sugeng L. TRICUSPID AND MITRAL REMODELING IN ATRIAL FIBRILLATION: A THREE-DIMENSIONAL ECHOCARDIOGRAPHIC STUDY. Journal Of The American College Of Cardiology 2020, 75: 1706. DOI: 10.1016/s0735-1097(20)32333-0.Peer-Reviewed Original ResearchCHANGES OF LEFT ATRIAL APPENDAGE ORIFICE FOLLOWING PERCUTANEOUS LEFT ATRIAL APPENDAGE CLOSURE USING THREE-DIMENSIONAL ECHOCARDIOGRAPHY
Ortiz-Leon X, Posada E, Chen W, Bregasi A, Crandall I, Pereira J, Miranda J, Akar J, Lin B, McNamara R, Freeman J, Curtis J, Arias-Godínez J, Sugeng L. CHANGES OF LEFT ATRIAL APPENDAGE ORIFICE FOLLOWING PERCUTANEOUS LEFT ATRIAL APPENDAGE CLOSURE USING THREE-DIMENSIONAL ECHOCARDIOGRAPHY. Journal Of The American College Of Cardiology 2020, 75: 1708. DOI: 10.1016/s0735-1097(20)32335-4.Peer-Reviewed Original Research
2019
Patient, clinician and logistic barriers to blood pressure control among adult hypertensives in rural district hospitals in Rwanda: a cross-sectional study
Sibomana J, McNamara R, Walker T. Patient, clinician and logistic barriers to blood pressure control among adult hypertensives in rural district hospitals in Rwanda: a cross-sectional study. BMC Cardiovascular Disorders 2019, 19: 231. PMID: 31638907, PMCID: PMC6805529, DOI: 10.1186/s12872-019-1203-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntihypertensive AgentsBlood PressureClinical CompetenceCross-Sectional StudiesFemaleGuideline AdherenceHospitals, RuralHumansHypertensionMaleMedication AdherenceMiddle AgedPhysician's RolePractice Guidelines as TopicPractice Patterns, Physicians'RwandaTime FactorsTreatment OutcomeYoung AdultConceptsRural district hospitalDistrict hospitalsBlood pressure controlBarriers to effective blood pressure controlRural Rwandan district hospitalsAssociated with poor blood pressure controlRwandan district hospitalsBarriers to blood pressure controlPoor blood pressure controlMethodsThis cross-sectionalCross-sectional studyLogistical factorsMedication side effectsPressure controlAnti-hypertensive medicationsHypertensive patientsSociodemographic factorsBlood pressureBlood pressure dataPrescribed medicationsEffective blood pressure controlJNC 8 recommendationsGoal blood pressurePatient factorsMedical costs
2018
Three-Dimensional Ultrasound Imaging of Inferior Vena Cava Outperforms Standard Two-Dimensional Imaging as a Diagnostic Tool in Heart Failure
Struyk G, Essa M, Flueckiger P, Bregasi A, McNamara R, Sugeng L, Testani J, Lin B. Three-Dimensional Ultrasound Imaging of Inferior Vena Cava Outperforms Standard Two-Dimensional Imaging as a Diagnostic Tool in Heart Failure. Journal Of Cardiac Failure 2018, 24: s41. DOI: 10.1016/j.cardfail.2018.07.119.Peer-Reviewed Original ResearchRight atrial pressureJugular venous pressureHeart failureCollapsibility indexIVC diameterDiagnostic performanceInferior vena cava diameterSphericity indexMethods 200 patientsIntravascular volume statusVena cava diameterCertain clinical variablesROC curve analysisDiuretic therapyAtrial pressureVenous pressureVolume statusClinical parametersClinical variablesIVC diameter measurementsCHF diagnosisIVC measurementsIVC areaASE guidelinesIVC parametersPROGNOSTIC VALUE OF INFERIOR VENA CAVA SIZE BY ULTRASOUND IN PATIENTS WITH HEART FAILURE
Trejo M, Cabezas F, Hersey D, Moore C, Lin B, McNamara R. PROGNOSTIC VALUE OF INFERIOR VENA CAVA SIZE BY ULTRASOUND IN PATIENTS WITH HEART FAILURE. Journal Of The American College Of Cardiology 2018, 71: a1529. DOI: 10.1016/s0735-1097(18)32070-9.Peer-Reviewed Original ResearchCHANGES IN HOSPITAL PERFORMANCE AND TRANSITION-CARE MEASURES 1-YEAR AFTER INITIATION OF THE PATIENT NAVIGATOR PROGRAM
Albert N, Gluckman T, McNamara R, Fonarow G, Malik A, Brindis R, Lu D, Roe M, Tingley J, Negi S, Goldberg L, Rogers S, Mobayed J, Patel S, Pruski B, Hewitt K, Fanari Z, Lucas J. CHANGES IN HOSPITAL PERFORMANCE AND TRANSITION-CARE MEASURES 1-YEAR AFTER INITIATION OF THE PATIENT NAVIGATOR PROGRAM. Journal Of The American College Of Cardiology 2018, 71: a655. DOI: 10.1016/s0735-1097(18)31196-3.Peer-Reviewed Original ResearchRIGHT ATRIAL PRESSURE ESTIMATES BY 2D AND 3D INFERIOR VENA CAVA MEASUREMENTS ARE DISCORDANT
Essa M, Flueckiger P, McNamara R, Sugeng L, Testani J, Lin B. RIGHT ATRIAL PRESSURE ESTIMATES BY 2D AND 3D INFERIOR VENA CAVA MEASUREMENTS ARE DISCORDANT. Journal Of The American College Of Cardiology 2018, 71: a1617. DOI: 10.1016/s0735-1097(18)32158-2.Peer-Reviewed Original Research