2016
Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse
LaMotte RH. Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse. Advances In Experimental Medicine And Biology 2016, 904: 23-32. PMID: 26900060, PMCID: PMC4910628, DOI: 10.1007/978-94-017-7537-3_2.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisPersistent itchPathogenesis of ACDSquaric acid dibutyl esterPain-like behaviorsSmall-diameter neuronsPeripheral neural mechanismsPossible therapeutic targetInflammatory itchPruritic disordersCutaneous sitesChemokine CXCL10Excitatory responsesLocal inflammationReceptor CXCR3Contact dermatitisUnmyelinated axonsSpontaneous activityTherapeutic targetAnimal modelsPainSubsequent challengeTopical applicationItchMice
2015
Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis
Pall PS, Hurwitz OE, King BA, LaMotte RH. Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis. Journal Of Pain 2015, 16: 741-749. PMID: 26002605, PMCID: PMC4522332, DOI: 10.1016/j.jpain.2015.04.009.Peer-Reviewed Original ResearchConceptsSquaric acid dibutyl esterAllergic contact dermatitisSpontaneous itchContact dermatitisNociceptive sensationsT cell-mediated inflammationExperimental modelPeripheral neural activityQuality of lifeInflammatory itchBAM8-22Skin inflammationHypersensitivity reactionsPain sensationAllergen resultsIntradermal injectionCommon conditionHealthy volunteersPotential treatmentItchPsychophysical measurementsInflammationVolar forearmDermatitisNeural activity
2006
MCP-1 Enhances Excitability of Nociceptive Neurons in Chronically Compressed Dorsal Root Ganglia
Sun J, Yang B, Donnelly D, Ma C, LaMotte R. MCP-1 Enhances Excitability of Nociceptive Neurons in Chronically Compressed Dorsal Root Ganglia. Journal Of Neurophysiology 2006, 96: 2189-2199. PMID: 16775210, DOI: 10.1152/jn.00222.2006.Peer-Reviewed Original ResearchConceptsMonocyte chemoattractant protein-1Dorsal root gangliaNociceptive neuronsRoot gangliaCompressed dorsal root ganglionIntact dorsal root gangliaSmall DRG neuronsProportion of neuronsChemoattractant protein-1Action potential widthNonselective cation conductanceMagnitude of depolarizationCCD neuronsChronic compressionDRG neuronsExcitatory effectsReceptor CCR2Nociceptive propertiesIntact gangliaNeuronal expressionInward currentsNeuronsCurrent clampGangliaReversal potentialEffects of a Chronic Compression of the Dorsal Root Ganglion on Voltage-Gated Na+ and K+ Currents in Cutaneous Afferent Neurons
Tan Z, Donnelly D, LaMotte R. Effects of a Chronic Compression of the Dorsal Root Ganglion on Voltage-Gated Na+ and K+ Currents in Cutaneous Afferent Neurons. Journal Of Neurophysiology 2006, 95: 1115-1123. PMID: 16424456, DOI: 10.1152/jn.00830.2005.Peer-Reviewed Original ResearchConceptsDorsal root gangliaCCD neuronsRoot gangliaChronic compressionTTX-sensitiveL5 dorsal root gangliaWhole-cell patch-clamp recordingsCell patch-clamp recordingsCutaneous afferent neuronsEnhanced neuronal excitabilityTTX-resistant currentSteady-state activation curvePatch-clamp recordingsCutaneous hyperalgesiaCutaneous neuronsDRG somataAfferent neuronsControl neuronsControl ratsNeuronal somataNeuronal excitabilityAdult ratsSpontaneous activityIntervertebral foraminaLower rheobase
1999
Enhanced Excitability of Sensory Neurons in Rats With Cutaneous Hyperalgesia Produced by Chronic Compression of the Dorsal Root Ganglion
Zhang J, Song X, LaMotte R. Enhanced Excitability of Sensory Neurons in Rats With Cutaneous Hyperalgesia Produced by Chronic Compression of the Dorsal Root Ganglion. Journal Of Neurophysiology 1999, 82: 3359-3366. PMID: 10601467, DOI: 10.1152/jn.1999.82.6.3359.Peer-Reviewed Original ResearchConceptsDorsal root gangliaControl ratsCutaneous hyperalgesiaDRG cellsRoot gangliaSpontaneous activityChronic mechanical compressionCCD cellsAction potential thresholdDRG somataChronic compressionChronic painContralateral footSham operationElectrophysiological changesSpinal injuryIntracellular recordingsPunctate stimulationSensory pathologySensory neuronsIntervertebral foraminaIntrinsic alterationsElectrophysiological propertiesPlantar surfaceHyperalgesiaPlasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain
Dib-Hajj S, Fjell J, Cummins TR, Zheng Z, Fried K, LaMotte R, Black JA, Waxman S. Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain. Pain 1999, 83: 591-600. PMID: 10568868, DOI: 10.1016/s0304-3959(99)00169-4.Peer-Reviewed Original ResearchConceptsTTX-R sodium channelsChronic constriction injury modelDRG neuronsSodium currentSodium channelsNeuropathic painInjury modelAxotomized dorsal root ganglion (DRG) neuronsSmall-diameter DRG neuronsTTX-R sodium currentsDorsal root ganglion neuronsTTX-S currentsSodium channel expressionGanglion neuronsSciatic nerveChannel expressionSodium channel transcriptsNeuronsNa currentPainChannel transcriptsSignificant changesLevels of transcriptsHyperalgesiaPrevious studies
1997
Tensile and Compressive Responses of Nociceptors in Rat Hairy Skin
Khalsa P, Lamotte R, Grigg P. Tensile and Compressive Responses of Nociceptors in Rat Hairy Skin. Journal Of Neurophysiology 1997, 78: 492-505. PMID: 9242296, DOI: 10.1152/jn.1997.78.1.492.Peer-Reviewed Original ResearchConceptsCompressive stressCompressive loadingTensile stressApplied loadFlat indenter tipCompressive responseIndenter tipCompressive loadTensile loadSurface displacementsTip excursionCompressive strainForce controlTensile strainTip geometrySoft substratesLoadingLoadTensile stimulusHard substratesSubstrateStressIndentationCompressionUniform state
1993
Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells
Petersen M, LaMotte R. Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells. Pain 1993, 54: 37-42. PMID: 7690929, DOI: 10.1016/0304-3959(93)90097-9.Peer-Reviewed Original ResearchConceptsInward currentsDorsal root ganglion neuronsDorsal root ganglion cellsCapsaicin-evoked currentsWhole-cell voltage-clamp conditionsImportant modulatory roleVoltage-clamp conditionsDRG cellsGanglion neuronsGanglion cellsSensory neuronsModulatory roleCapsaicinProgressive decreaseNeuronsCellsExtracellular medium
1992
Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans.
Torebjörk H, Lundberg L, LaMotte R. Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans. The Journal Of Physiology 1992, 448: 765-780. PMID: 1593489, PMCID: PMC1176227, DOI: 10.1113/jphysiol.1992.sp019069.Peer-Reviewed Original ResearchConceptsMechanical hyperalgesiaCapsaicin injectionIntraneural microstimulationMechanoreceptive inputCapsaicin-induced secondary hyperalgesiaCutaneous innervation territoryArea of hyperalgesiaHealthy human subjectsSecondary hyperalgesiaAlgesic substancesLidocaine anesthesiaInnervation territoryIntense painIntradermal injectionUnmyelinated fibersHyperalgesiaMyelinated fibersC-fibersCentral changesPainAfferent signalsImpulse conductionSuprathreshold stimulationSkin areasTactile sensationPain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.
LaMotte R, Lundberg L, Torebjörk H. Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. The Journal Of Physiology 1992, 448: 749-764. PMID: 1593488, PMCID: PMC1176226, DOI: 10.1113/jphysiol.1992.sp019068.Peer-Reviewed Original ResearchConceptsDuration of painMagnitude of painC-nociceptorsCapsaicin injectionMechanical hyperalgesiaIntradermal injectionTopical applicationReceptive fieldsC-mechanoheat nociceptorsEffects of capsaicinMean discharge rateCutaneous hyperalgesiaHyperalgesic areaUnchanged responsivenessBackground painAlgesic substancesPeroneal nerveNociceptor excitabilityNociceptor responsesPain thresholdMechanical stimuliNociceptor dischargeIntense painConcomitant painAwake humans
1991
Relationships between capsaicin sensitivity of mammalian sensory neurons, cell size and type of voltage gated Ca-currents
Petersen M, LaMotte R. Relationships between capsaicin sensitivity of mammalian sensory neurons, cell size and type of voltage gated Ca-currents. Brain Research 1991, 561: 20-26. PMID: 1665752, DOI: 10.1016/0006-8993(91)90744-g.Peer-Reviewed Original ResearchConceptsCapsaicin sensitivityCultured adult rat dorsal root ganglion neuronsAdult rat dorsal root ganglion neuronsLow-threshold typeRat dorsal root ganglion neuronsWhole-cell patch-clamp techniqueDorsal root ganglion neuronsCultured dorsal root gangliaCapsaicin-sensitive cellsCapsaicin-sensitive populationCross-sectional areaDorsal root gangliaMammalian sensory neuronsPatch-clamp techniqueGanglion neuronsRoot gangliaSensory neuronsCa currentCell populationsActivation thresholdLength of timeLarger cross-sectional areaSectional areaCapsaicinSmall cell populationNeurogenic hyperalgesia: psychophysical studies of underlying mechanisms
LaMotte R, Shain C, Simone D, Tsai E. Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. Journal Of Neurophysiology 1991, 66: 190-211. PMID: 1919666, DOI: 10.1152/jn.1991.66.1.190.Peer-Reviewed Original ResearchConceptsInjection of capsaicinMechanical hyperalgesiaNerve fibersInjection siteAlgesic substancesPrimary afferent nerve fibersArea of tendernessCapsaicin injection siteMicrograms of capsaicinNociceptive nerve fibersPeripheral neural activityArea of hyperalgesiaCutaneous nerve fibersAfferent nerve fibersMagnitude of painSingle intradermal injectionNeural activityArea of analgesiaSite of injuryLarger mean areaAnesthetized skinNeurogenic hyperalgesiaCutaneous anesthesiaIntradermal injectionPainful stimuliPsychophysical Studies of the Itch Sensation and Itchy Skin (“Alloknesis”) Produced by Intracutaneous Injection of Histamine
Simone D, Alreja M, Lamotte R. Psychophysical Studies of the Itch Sensation and Itchy Skin (“Alloknesis”) Produced by Intracutaneous Injection of Histamine. Somatosensory & Motor Research 1991, 8: 271-279. PMID: 1767623, DOI: 10.3109/08990229109144750.Peer-Reviewed Original ResearchConceptsDuration of itchSubcutaneous injectionIntracutaneous injectionItchy skinArea of alloknesisSensation of itchMicrograms of histamineSkin temperatureItch sensationLocal anesthesiaAlloknesisMean latencyInjection siteMean maximum areaItchHuman volunteersHistamineVolar forearmDose-response functionInjectionNeural mechanismsSkinDoseDurationMicrograms
1989
Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin
Simone D, Baumann T, Collins J, LaMotte R. Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin. Brain Research 1989, 486: 185-189. PMID: 2720428, DOI: 10.1016/0006-8993(89)91293-6.Peer-Reviewed Original Research
1983
Tactile Detection Thresholds for a Single Asperity on an Otherwise Smooth Surface
Johansson R, Lamotte R. Tactile Detection Thresholds for a Single Asperity on an Otherwise Smooth Surface. Somatosensory & Motor Research 1983, 1: 21-31. PMID: 6679912, DOI: 10.3109/07367228309144538.Peer-Reviewed Original Research