2022
The changing landscape in epilepsy imaging: Unmasking subtle and unique entities
Adin ME, Department of Radiology and Biomedical Imaging Y, Durand D, Zucconi W, Huttner A, Spencer D, Bronen R, Department of Radiology Abbott Northwestern Hospital M, Department of Pathology Y, Department of Neurosurgery Y. The changing landscape in epilepsy imaging: Unmasking subtle and unique entities. Diagnostic And Interventional Radiology 2022, 28: 503-515. PMID: 35997478, PMCID: PMC9682800, DOI: 10.5152/dir.2022.21339.Peer-Reviewed Original ResearchConceptsHippocampal sclerosisCortical developmentLocalization-related epilepsyTemporal lobe encephaloceleFocal cortical dysplasiaFocal cortical dysplasia IIbField of epilepsyEpileptogenic abnormalitiesAutoimmune encephalitisRasmussen's encephalitisCommon etiologyCortical dysplasiaEpilepsy surgeryEpileptogenic substrateTuberous sclerosisEpilepsy imagingHippocampal malformationsMTOR pathwayEncephalitisSclerosisMR imagingMalformationsUnique entitySurgeryEpilepsy
2005
Apolipoprotein E epsilon4 is associated with atrophy of the amygdala in Alzheimer's disease
Basso M, Gelernter J, Yang J, MacAvoy MG, Varma P, Bronen RA, van Dyck CH. Apolipoprotein E epsilon4 is associated with atrophy of the amygdala in Alzheimer's disease. Neurobiology Of Aging 2005, 27: 1416-1424. PMID: 16182410, DOI: 10.1016/j.neurobiolaging.2005.08.002.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAD patientsAPOE epsilon4AD groupImportant genetic risk factorApolipoprotein E epsilon4Regional brain atrophyAPOE epsilon4 alleleElderly control subjectsNormal elderly control subjectsGenetic risk factorsAmygdaloid volumesBrain atrophyControl subjectsEpsilon4 carriersRisk factorsEpsilon4 alleleHippocampal volumeEpsilon4 doseAnalysis of covarianceDisease severityPatientsEpsilon4AmygdalaAtrophy
2000
Cerebrospinal Fluid Cleft with Cortical Dimple: MR Imaging Marker for Focal Cortical Dysgenesis
Bronen RA, Spencer DD, Fulbright RK. Cerebrospinal Fluid Cleft with Cortical Dimple: MR Imaging Marker for Focal Cortical Dysgenesis. Radiology 2000, 214: 657-63. PMID: 10715026, DOI: 10.1148/radiology.214.3.r00mr40657.Peer-Reviewed Original Research
1997
Topographic distribution of seizure onset and hippocampal atrophy: Relationship between MRI and depth EEG
King D, Bronen R, Spencer D, Spencer S. Topographic distribution of seizure onset and hippocampal atrophy: Relationship between MRI and depth EEG. Clinical Neurophysiology 1997, 103: 692-697. PMID: 9546496, DOI: 10.1016/s0013-4694(97)00090-4.Peer-Reviewed Original ResearchConceptsMedial temporal lobe epilepsyMagnetic resonance imagingSegmental atrophyHippocampal atrophyIctal onsetCell lossTopographic distributionDepth EEGHippocampal cell lossAnterior temporal lobectomyTemporal lobe epilepsyHippocampal depth electrodesMedial temporal structuresDistribution of onsetMost patientsTemporal lobectomyFocal onsetLobe epilepsyExcellent outcomesIctal recordingsDentate gyrusHippocampal segmentsSeizure onsetSubdural stripsDepth electrode contacts
1995
Regional distribution of MR findings in hippocampal sclerosis.
Bronen RA, Fulbright RK, Kim JH, Spencer SS, Spencer DD, al-Rodhan NR. Regional distribution of MR findings in hippocampal sclerosis. American Journal Of Neuroradiology 1995, 16: 1193-200. PMID: 7677010, PMCID: PMC8337833.Peer-Reviewed Original ResearchConceptsHippocampal sclerosisHippocampal bodyHippocampal headMR findingsHippocampal tailMR abnormalitiesLimbic structuresAbnormal MR findingsConsecutive patientsIpsilateral hippocampusMost patientsSignal changesSeizure generatorPathologic analysisHyperintense signalRegional atrophyEntire hippocampusPatientsSclerosisHippocampusAmygdalaAtrophyMR changesMR scansWidespread involvement
1992
Quantitative magnetic resonance imaging in temporal lobe epilepsy: Relationship to neuropathology and neuropsychological function
Lencz T, McCarthy G, Bronen R, Scott T, Inserni J, Sass K, Novelly R, Kim J, Spencer D. Quantitative magnetic resonance imaging in temporal lobe epilepsy: Relationship to neuropathology and neuropsychological function. Annals Of Neurology 1992, 31: 629-637. PMID: 1514774, DOI: 10.1002/ana.410310610.Peer-Reviewed Original ResearchConceptsControl subjectsLeft temporal lobeTemporal lobeSeizure focusNeuronal densityHippocampal measurementsRight-handed control subjectsMagnetic resonance imagesHippocampal neuronal densityTemporal lobe originEpileptic temporal lobeTemporal lobe epilepsySignificant correlationQuantitative magnetic resonanceRefractory epilepsyLobe epilepsyPatient groupSelective Reminding TestHippocampal ratioLeft hippocampusHippocampal subfieldsPatientsWechsler Memory ScaleNeuropsychological functionHippocampus