Featured Publications
Medial Nucleus Accumbens Projections to the Ventral Tegmental Area Control Food Consumption
Bond CW, Trinko R, Foscue E, Furman K, Groman SM, Taylor JR, DiLeone RJ. Medial Nucleus Accumbens Projections to the Ventral Tegmental Area Control Food Consumption. Journal Of Neuroscience 2020, 40: 4727-4738. PMID: 32354856, PMCID: PMC7294796, DOI: 10.1523/jneurosci.3054-18.2020.Peer-Reviewed Original ResearchConceptsControl food intakeNAc projectionsFood intakeAccumbens projectionsLateral hypothalamusMesolimbic circuitsFood consumptionNucleus accumbens projectionsFood-seeking behaviorNAC controlVTA pathwayInhibitory projectionsMale miceNAc shellOptogenetic activationFiber photometryOptogenetic inhibitionPermissive rolePharmacological studiesDrug rewardVTAConsummatory behaviorIntakeAdaptive inhibitionNeural activityMedial prefrontal D1 dopamine neurons control food intake
Land BB, Narayanan NS, Liu RJ, Gianessi CA, Brayton CE, M Grimaldi D, Sarhan M, Guarnieri DJ, Deisseroth K, Aghajanian GK, DiLeone RJ. Medial prefrontal D1 dopamine neurons control food intake. Nature Neuroscience 2014, 17: 248-253. PMID: 24441680, PMCID: PMC3968853, DOI: 10.1038/nn.3625.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAnalysis of VarianceAnimalsBiophysicsCalcium-Calmodulin-Dependent Protein Kinase Type 2ChannelrhodopsinsEatingElectric StimulationFemaleFood DeprivationFunctional LateralityGene Expression RegulationIn Vitro TechniquesLuminescent ProteinsMaleMembrane PotentialsMiceMice, Inbred C57BLMice, TransgenicNeural InhibitionNeural PathwaysNeuronsOptogeneticsPatch-Clamp TechniquesPhotic StimulationPrefrontal CortexReceptors, Dopamine D1Time Factors
2012
Prefrontal D1 dopamine signaling is required for temporal control
Narayanan NS, Land BB, Solder JE, Deisseroth K, DiLeone RJ. Prefrontal D1 dopamine signaling is required for temporal control. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 20726-20731. PMID: 23185016, PMCID: PMC3528521, DOI: 10.1073/pnas.1211258109.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBehavior, AnimalBiological ClocksMaleMiceMice, TransgenicModels, NeurologicalNeural PathwaysOptogeneticsPrefrontal CortexRatsReceptors, Dopamine D1RewardRNA InterferenceRNA, Small InterferingSignal TransductionSynaptic TransmissionTime FactorsTyrosine 3-MonooxygenaseVentral Tegmental AreaConceptsVentral tegmental areaD1 dopamine receptorsDopamine receptorsTegmental areaDopaminergic projectionsPrefrontal neuronsMidbrain ventral tegmental areaD2 dopamine receptorsDopaminergic inputD1 receptorsDopaminergic neurotransmissionD1 dopamineDopaminergic diseasesTyrosine hydroxylaseDopamine signalingReceptorsPharmacological disruptionSelective inhibitionGoal-directed behaviorNeuronsRNA interferenceTiming taskBehavioral goalsControlNeurotransmission