2023
CMPK2 restricts Zika virus replication by inhibiting viral translation
Pawlak J, Hsu J, Xia H, Han P, Suh H, Grove T, Morrison J, Shi P, Cresswell P, Laurent-Rolle M. CMPK2 restricts Zika virus replication by inhibiting viral translation. PLOS Pathogens 2023, 19: e1011286. PMID: 37075076, PMCID: PMC10150978, DOI: 10.1371/journal.ppat.1011286.Peer-Reviewed Original ResearchConceptsCytidine/uridine monophosphate kinase 2I interferon-stimulated genesZika virus replicationYellow fever virusAntiviral activityAntiviral effectVirus replicationKunjin virusType I interferon-stimulated genesFirst lineOverall antiviral responseHost's first lineEffective therapeutic interventionsViral translationBroad antiviral activityInterferon-stimulated genesGlobal health threatAntiviral treatmentFlaviviral infectionsPathogenic flavivirusesAntiviral functionDrug AdministrationTherapeutic interventionsAntiviral responseDengue virus
2021
Translational regulation of viral RNA in the type I interferon response
Hsu J, Laurent-Rolle M, Cresswell P. Translational regulation of viral RNA in the type I interferon response. Current Research In Virological Science 2021, 2: 100012. DOI: 10.1016/j.crviro.2021.100012.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsInterferon-stimulated genesViral infectionViral replicationIFN-I responsesType I interferon responseAntigen-independent mannerInnate immune responseVariety of mechanismsI interferon responseImmune responseVirus life cycleInfectious organismsInterferon responseHost factorsInfectionFirst lineViral RNAViral proteinsType IViral translationCommon cellular responseMolecular mechanismsInhibitionCellular responsesTranslation inhibition