Role of a patatin-like phospholipase in Plasmodium falciparum gametogenesis and malaria transmission
Singh P, Alaganan A, More K, Lorthiois A, Thiberge S, Gorgette O, Guillotte Blisnick M, Guglielmini J, Aguilera S, Touqui L, Singh S, Chitnis C. Role of a patatin-like phospholipase in Plasmodium falciparum gametogenesis and malaria transmission. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 17498-17508. PMID: 31413195, PMCID: PMC6717283, DOI: 10.1073/pnas.1900266116.Peer-Reviewed Original ResearchConceptsFemale gametesPerforin-like proteinBlood-stage growthIngestion of gametocytesProcess of gametogenesisPatatin-like phospholipaseGamete egressDiverse organismsMembrane remodelingIntracellular vesiclesVesicle secretionVesicular dischargeMale gametesOocyst formationPeripheral membraneGametocyte developmentGametogenesisExtensive membraneConditional deletionGametesBlood mealDevelopment of drugsDeletionPotential targetGenes