2023
Timeliness of diagnostic evaluation for postmenopausal bleeding: A retrospective cohort study using claims data
Xu X, Chen L, Nunez-Smith M, Clark M, Wright J. Timeliness of diagnostic evaluation for postmenopausal bleeding: A retrospective cohort study using claims data. PLOS ONE 2023, 18: e0289692. PMID: 37682914, PMCID: PMC10490884, DOI: 10.1371/journal.pone.0289692.Peer-Reviewed Original ResearchConceptsPostmenopausal bleedingFirst diagnostic procedureDiagnostic evaluationDiagnostic proceduresGynecologic conditionsMedicaid patientsCox proportional hazards modelPrompt diagnostic evaluationRetrospective cohort studyMarketScan Research DatabasesAdditional risk factorsNon-clinical factorsCommon gynecologic conditionProportional hazards modelLower ratesCohort studyMost patientsPatient characteristicsBenign etiologyGynecologic cancerCancer patientsPreventive careUterine cancerInsurance typeRisk factors
2022
Validation of the KELIM score as a predictor of response to neoadjuvant treatment in patients with advanced high grade serous ovarian cancer
Piedimonte S, Kim R, Bernardini M, Atenafu E, Clark M, Lheureux S, May T. Validation of the KELIM score as a predictor of response to neoadjuvant treatment in patients with advanced high grade serous ovarian cancer. Gynecologic Oncology 2022, 167: 417-422. PMID: 37191644, DOI: 10.1016/j.ygyno.2022.10.014.Peer-Reviewed Original ResearchConceptsKaplan-Meier survival analysisOutcomes of cytoreductionRetrospective cohort studyDays of chemotherapyCA 125 valuesMeier survival analysisLocal ethics boardCytoreductive outcomeMedian pfsCohort studyInhibitor useTreatment delayFunctional statusBRCA statusInclusion criteriaHigh riskPlatinum sensitivityStage IIIPatientsSurvival analysisEthics BoardHigh gradeSignificant differencesNACTPoly adenosineThe modeled CA-125 elimination rate constant k (KELIM) score as a predictor of treatment response in patients with advanced high grade serous ovarian cancer (190)
Piedimonte S, Kim S, Clark M, Lheureux S, May T, Bernardini M, Atenafu E. The modeled CA-125 elimination rate constant k (KELIM) score as a predictor of treatment response in patients with advanced high grade serous ovarian cancer (190). Gynecologic Oncology 2022, 166: s109. DOI: 10.1016/s0090-8258(22)01417-2.Peer-Reviewed Original ResearchHigh-grade serous ovarian cancerAdvanced high-grade serous ovarian cancerPlatinum-free intervalSerous ovarian cancerNeoadjuvant chemotherapyOverall survivalCA 125BRCA statusOvarian cancerHigh CA 125 levelsMedian platinum-free intervalKaplan-Meier survival analysisGrade serous ovarian cancerBaseline CA-125Lower median PFSCA-125 levelsPlatinum-resistant diseasePlatinum-sensitive diseaseRetrospective cohort studyTertiary cancer centerDays of chemotherapySubset of patientsCA 125 valuesBRCA mutation statusSignificant differences
2021
Survival of Older Women With Cervical Cancer Based on Screening History.
Clark M, Jembere N, Wang L, Kupets R. Survival of Older Women With Cervical Cancer Based on Screening History. Journal Of Lower Genital Tract Disease 2021, 25: 9-14. PMID: 33347044, DOI: 10.1097/lgt.0000000000000582.Peer-Reviewed Original ResearchConceptsInvasive cervical cancerWomen 50 yearsPrimary care physiciansCervical cancerOverall survivalScreening historyCare physiciansPopulation-level retrospective cohort studyMultivariate analysisHealth care administrative databasesFour-year OSRetrospective cohort studyCervical screening historyUnscreened womenAdvanced diseaseCohort studyScreened groupSurvival benefitImproved survivalCervical screeningKaplan-MeierUnivariate analysisAdministrative databasesOlder womenAge groups
2019
Pseudovascular Invasion: Minimally Invasive Surgery for Endometrial Cancer
Seifi F, Parkash V, Clark M, Menderes G, Tierney C, Silasi DA, Azodi M. Pseudovascular Invasion: Minimally Invasive Surgery for Endometrial Cancer. JSLS Journal Of The Society Of Laparoscopic & Robotic Surgeons 2019, 23: e2019.00021. PMID: 31285650, PMCID: PMC6596444, DOI: 10.4293/jsls.2019.00021.Peer-Reviewed Original ResearchConceptsLymphovascular space invasionEndometrial cancerSpace invasionEarly-stage endometrial cancerPatients meeting eligibility criteriaInvasive surgical stagingStage endometrial cancerRetrospective cohort studyBody mass indexMeeting eligibility criteriaPeritoneal cytologyAdjuvant radiotherapyAdjuvant therapyAdjuvant treatmentSurgical stagingCohort studyLymphovascular invasionSerous histologyPathologic evaluationMass indexGynecologic pathologistsSubgroup analysisTumor gradeUterine manipulatorIntrauterine manipulator