2024
T32. GENETIC ARCHITECTURE OF BIPOLAR SPECTRUM DISORDERS IN NEARLY 102,000 LATINO ANCESTRY INDIVIDUALS
Bigdeli T, Voloudakis G, Chatzinakos C, Barr P, Gorman B, Peterson R, Pyarajan S, Huang G, Gaziano M, Pato M, Fanous A, Pato C, Aslan M, Roussos P, Harvey P. T32. GENETIC ARCHITECTURE OF BIPOLAR SPECTRUM DISORDERS IN NEARLY 102,000 LATINO ANCESTRY INDIVIDUALS. European Neuropsychopharmacology 2024, 87: 173-174. DOI: 10.1016/j.euroneuro.2024.08.342.Peer-Reviewed Original ResearchGenome-wide association studiesPolygenic risk scoresEuropean ancestryMillion Veteran ProgramAdmixed AmericansGenomic Psychiatry CohortGenome-wide association study analysisGenome-wide significant signalsMulti-ancestry meta-analysisLocal ancestry inferenceStatistical fine-mappingBipolar disorderCooperative Studies ProgramGenomic structural equation modelingLatino individualsAncestry inferencePRS-CSxTrans-diagnostic approachBipolar spectrum disordersEast Asian populationsFine-mappingAssociation studiesGWAS statisticsPsychiatric genetic researchAncestry individuals
2020
Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program
Levey DF, Gelernter J, Polimanti R, Zhou H, Cheng Z, Aslan M, Quaden R, Concato J, Radhakrishnan K, Bryois J, Sullivan PF, Stein M. Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program. American Journal Of Psychiatry 2020, 177: 223-232. PMID: 31906708, PMCID: PMC7869502, DOI: 10.1176/appi.ajp.2019.19030256.Peer-Reviewed Original ResearchConceptsNovel genome-wide significant associationsGene expressionGenome-wide significant signalsGenome-wide significant associationMillion Veteran ProgramWide association studyGenetic risk lociSignificant genetic correlationsGenetic risk mechanismsGenetic architectureGlobal regulatorChromosome 3Risk lociChromosome 6Chromosome 7Association studiesLargest GWASLarge biobanksGlobal regulationGenetic correlationsContinuous traitsVeteran ProgramGWASsLociPrevious GWASs