2019
Improving Outcomes in INTERMACS 1 Category 1 Patients with Pre-LVAD, Awake Venous-Arterial Extracorporeal Membrane Oxygenation Support
Mori M, McCloskey G, Geirsson A, Mangi AA, Yun JJ, Jacoby D, Ahmad T, Bellumkonda L, Lee F, Chen ME, Bonde P. Improving Outcomes in INTERMACS 1 Category 1 Patients with Pre-LVAD, Awake Venous-Arterial Extracorporeal Membrane Oxygenation Support. ASAIO Journal 2019, Publish Ahead of Print: &na;. PMID: 30664019, DOI: 10.1097/mat.0000000000000908.Peer-Reviewed Original ResearchConceptsCategory 1 patientsECMO supportDurable LVADECMO groupDurable left ventricular assist device implantationVenous-arterial extracorporeal membrane oxygenationLeft ventricular assist device implantationVentricular assist device implantationCox proportional hazards analysisExtracorporeal membrane oxygenation supportECMO-supported patientsPost-LVAD survivalVenous-arterial ECMOOutcomes of patientsAssist device implantationEnd-organ functionMembrane oxygenation supportProportional hazards analysisExtracorporeal membrane oxygenationRisk of deathINTERMACS scaleInteragency RegistryOxygenation supportECMO patientsUnadjusted survival
2017
Plasma Levels of MicroRNA-155 Are Upregulated with Long-Term Left Ventricular Assist Device Support
Wang T, O’Brien E, Rogers JG, Jacoby DL, Chen ME, Testani JM, Bowles DE, Milano CA, Felker GM, Patel CB, Bonde PN, Ahmad T. Plasma Levels of MicroRNA-155 Are Upregulated with Long-Term Left Ventricular Assist Device Support. ASAIO Journal 2017, 63: 536-541. PMID: 28319523, PMCID: PMC5585122, DOI: 10.1097/mat.0000000000000564.Peer-Reviewed Original ResearchConceptsLVAD supportHeart failureMechanically Assisted Circulatory Support level 1Continuous-flow LVAD implantationLong-term LVAD supportMiR-155Ventricular assist device therapyMicroRNA-155Ventricular assist device supportPost-LVAD placementAdverse clinical outcomesAssist device supportPlasma expression levelsSupport level 1Real-time polymerase chain reactionQuantitative real-time polymerase chain reactionRelative quantification valuesContinuous blood flowWilcoxon signed-rank testMultiple biologic processesLVAD physiologyMeasurement of miRNAsInteragency RegistryLVAD implantationHF pathogenesisCompensatory Distal Reabsorption Drives Diuretic Resistance in Human Heart Failure
Rao VS, Planavsky N, Hanberg JS, Ahmad T, Brisco-Bacik MA, Wilson FP, Jacoby D, Chen M, Tang WHW, Cherney DZI, Ellison DH, Testani JM. Compensatory Distal Reabsorption Drives Diuretic Resistance in Human Heart Failure. Journal Of The American Society Of Nephrology 2017, 28: 3414-3424. PMID: 28739647, PMCID: PMC5661276, DOI: 10.1681/asn.2016111178.Peer-Reviewed Original ResearchConceptsDiuretic resistanceHeart failureLoop diureticsSodium reabsorptionHigh-dose loop diureticsDistal tubular sodium reabsorptionSodium exitLoop diuretic administrationTubular sodium reabsorptionHuman heart failureFurosemide equivalentsDistal reabsorptionConsecutive patientsFractional excretionSodium handlingDiuretic administrationProximal tubularControl cohortCare centerTreatment strategiesAnimal modelsDiureticsNet sodiumFENaTubular location
2016
Rapid and Highly Accurate Prediction of Poor Loop Diuretic Natriuretic Response in Patients With Heart Failure
Testani JM, Hanberg JS, Cheng S, Rao V, Onyebeke C, Laur O, Kula A, Chen M, Wilson FP, Darlington A, Bellumkonda L, Jacoby D, Tang WH, Parikh CR. Rapid and Highly Accurate Prediction of Poor Loop Diuretic Natriuretic Response in Patients With Heart Failure. Circulation Heart Failure 2016, 9: e002370. PMID: 26721915, PMCID: PMC4741370, DOI: 10.1161/circheartfailure.115.002370.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdministration, IntravenousAgedBiomarkersBumetanideDrug MonitoringDrug ResistanceFemaleHeart FailureHumansMaleMiddle AgedModels, BiologicalNatriuresisPredictive Value of TestsProspective StudiesReproducibility of ResultsSodiumSodium Potassium Chloride Symporter InhibitorsTime FactorsTreatment OutcomeUrinalysisConceptsAcute decompensated heart failureDecompensated heart failureNatriuretic responseSpot urine samplesSodium outputHeart failureDiuretic administrationAcute decompensated heart failure patientsDecompensated heart failure patientsLoop diuretic administrationPrimary therapeutic objectiveUrine samplesHeart failure patientsPositive sodium balanceNet fluid outputDiuretic dosingIntravenous bumetanideMedian doseFailure patientsDiuretic responseSodium balanceUrine collectionFluid balanceTherapeutic objectivesFluid output
2015
Familial dilated cardiomyopathy diagnosis is commonly overlooked at the time of transplant listing
Seidelmann SB, Laur O, Hwa J, Depasquale E, Bellumkonda L, Sugeng L, Pomianowski P, Testani J, Chen M, McKenna W, Jacoby D. Familial dilated cardiomyopathy diagnosis is commonly overlooked at the time of transplant listing. The Journal Of Heart And Lung Transplantation 2015, 35: 474-480. PMID: 26852066, PMCID: PMC5423783, DOI: 10.1016/j.healun.2015.12.002.Peer-Reviewed Original ResearchConceptsEnd-stage heart failureStage heart failureHeart failureUNOS registryEchocardiographic findingsUNOS databaseTeaching hospitalDetailed pedigree analysisVentricular end-diastolic dimensionPanel reactive antibody levelsTertiary care teaching hospitalLarge tertiary teaching hospitalCenter-specific dataAdvanced heart failureEnd-diastolic dimensionOrgan Sharing registryMajority of patientsNon-ischemic DCMTertiary teaching hospitalMitral valve annulusDetailed family historyTransplant listingAdult patientsClinical characteristicsUNOS data