2021
Preservation of vision after CaMKII-mediated protection of retinal ganglion cells
Guo X, Zhou J, Starr C, Mohns EJ, Li Y, Chen EP, Yoon Y, Kellner CP, Tanaka K, Wang H, Liu W, Pasquale LR, Demb JB, Crair MC, Chen B. Preservation of vision after CaMKII-mediated protection of retinal ganglion cells. Cell 2021, 184: 4299-4314.e12. PMID: 34297923, PMCID: PMC8530265, DOI: 10.1016/j.cell.2021.06.031.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBrainCalcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP Response Element-Binding ProteinCytoprotectionDependovirusDisease Models, AnimalEnzyme ActivationGlaucomaMice, Inbred C57BLNeurotoxinsOptic Nerve InjuriesRetinal Ganglion CellsSignal TransductionVision, OcularConceptsRetinal ganglion cellsRGC survivalRGC somataGanglion cellsDiverse insultsRGC axon projectionOptic nerve injurySole output neuronsPreservation of visionElevated intraocular pressureIrreversible vision lossPathological statesExcitotoxic injuryNerve injuryGlaucoma modelIntraocular pressureRGC axonsVision lossVisual functionNormal retinaVisual cortexAxon projectionsGenetic deficiencyInjuryRetina
2012
Role of adenylate cyclase 1 in retinofugal map development
Dhande OS, Bhatt S, Anishchenko A, Elstrott J, Iwasato T, Swindell EC, Xu H, Jamrich M, Itohara S, Feller MB, Crair MC. Role of adenylate cyclase 1 in retinofugal map development. The Journal Of Comparative Neurology 2012, 520: 1562-1583. PMID: 22102330, PMCID: PMC3563095, DOI: 10.1002/cne.23000.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusDorsal lateral geniculate nucleusAdenylate cyclase 1Superior colliculusRetinal wavesRetinal ganglion cell projectionsEye-specific segregationGanglion cell projectionsSpontaneous retinal wavesSecond postnatal weekActivity-dependent processesCyclase 1Production of cAMPRGC axonsGeniculate nucleusPostnatal weekMammalian visual systemDevelopment of retinotopySomatotopic mapMutant miceSensory peripheryMiceConditional deletionTermination zonesDependent manner
2011
Development of Single Retinofugal Axon Arbors in Normal and β2 Knock-Out Mice
Dhande OS, Hua EW, Guh E, Yeh J, Bhatt S, Zhang Y, Ruthazer ES, Feller MB, Crair MC. Development of Single Retinofugal Axon Arbors in Normal and β2 Knock-Out Mice. Journal Of Neuroscience 2011, 31: 3384-3399. PMID: 21368050, PMCID: PMC3060716, DOI: 10.1523/jneurosci.4899-10.2011.Peer-Reviewed Original ResearchConceptsDorsal lateral geniculate nucleusRetinal ganglion cellsSuperior colliculusAxon arborsRetinotopic refinementEye-specific segregationReceptor mutant miceLateral geniculate nucleusActivity-dependent mechanismsNormal developmentWT miceRGC axonsRetinal wavesGanglion cellsGeniculate nucleusMutant miceRole of activityMiceSpecific cuesArborsSparse branchesSame ageLabeling techniqueMaturationDevelopmental period
2008
Bone Morphogenetic Proteins, Eye Patterning, and Retinocollicular Map Formation in the Mouse
Plas DT, Dhande OS, Lopez JE, Murali D, Thaller C, Henkemeyer M, Furuta Y, Overbeek P, Crair MC. Bone Morphogenetic Proteins, Eye Patterning, and Retinocollicular Map Formation in the Mouse. Journal Of Neuroscience 2008, 28: 7057-7067. PMID: 18614674, PMCID: PMC2667968, DOI: 10.1523/jneurosci.3598-06.2008.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusSuperior colliculusOptic tractRetinotopic map formationRetinal ganglion cell axonsBone morphogenetic proteinCentral brain targetsRetinocollicular map formationGanglion cell axonsMap formationWild-type miceStrains of miceAxon behaviorEarly eye formationAxon orderRetinal cell fateOptic chiasmRGC axonsBrain targetsGeniculate nucleusCell axonsPotential downstream effectorsAxon sortingMorphogenetic proteinsMice