2021
Efferent feedback controls bilateral auditory spontaneous activity
Wang Y, Sanghvi M, Gribizis A, Zhang Y, Song L, Morley B, Barson DG, Santos-Sacchi J, Navaratnam D, Crair M. Efferent feedback controls bilateral auditory spontaneous activity. Nature Communications 2021, 12: 2449. PMID: 33907194, PMCID: PMC8079389, DOI: 10.1038/s41467-021-22796-8.Peer-Reviewed Original ResearchConceptsSpontaneous activityEfferent modulationEfferent pathwaysMedial olivocochlear systemCentral nervous systemCentral auditory systemInner hair cellsAuditory systemNicotinic acetylcholine receptorsSpontaneous activity patternsOlivocochlear systemHearing onsetEfferent systemChemogenetic experimentsBilateral couplingNervous systemAcetylcholine receptorsCircuit formationEfferent feedbackFiring patternsHair cellsΑ9/Auditory sensitivityBilateral correlationActivity patterns
2018
Homeostatic Control of Spontaneous Activity in the Developing Auditory System
Babola TA, Li S, Gribizis A, Lee BJ, Issa JB, Wang HC, Crair MC, Bergles DE. Homeostatic Control of Spontaneous Activity in the Developing Auditory System. Neuron 2018, 99: 511-524.e5. PMID: 30077356, PMCID: PMC6100752, DOI: 10.1016/j.neuron.2018.07.004.Peer-Reviewed Original ResearchConceptsSpiral ganglion neuronsSpontaneous activityAuditory systemDirect neuronal excitationGlutamate releaseEnhanced excitabilityGanglion neuronsUnanesthetized miceSynaptic excitationHearing onsetNeuronal excitationTherapeutic approachesMouse modelSpontaneous burstsCongenital formSynchronized activityHair cellsHomeostatic mechanismsNeuronsHomeostatic controlSimilar frequencyCircuit developmentMiceInfluence developmentDeafness