2023
Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior
Benisty H, Barson D, Moberly A, Lohani S, Tang L, Coifman R, Crair M, Mishne G, Cardin J, Higley M. Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior. Nature Neuroscience 2023, 27: 148-158. PMID: 38036743, PMCID: PMC11316935, DOI: 10.1038/s41593-023-01498-y.Peer-Reviewed Original ResearchConceptsFunctional connectivitySpontaneous behaviorCortical networksCortical network activityTime-varying functional connectivityFunctional magnetic resonanceCerebral cortexAwake miceDynamic functional connectivityAwake animalsNeighboring neuronsPatterned activityDistinct behavioral statesTwo-photon microscopyNeural activityCortical signalsBehavioral statesCortexNetwork activityCortical dynamicsMagnetic resonance
2019
Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits
Barson D, Hamodi AS, Shen X, Lur G, Constable RT, Cardin JA, Crair MC, Higley MJ. Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits. Nature Methods 2019, 17: 107-113. PMID: 31686040, PMCID: PMC6946863, DOI: 10.1038/s41592-019-0625-2.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptide-expressing interneuronsBrain-wide network dynamicsTwo-photon calcium imagingEntire cortical mantleLocal neuronal circuitsLong-range cortical networksWidespread gene deliveryWidefield calciumPyramidal neuronsAwake miceCortical circuitsNeuronal activityCortical mantleTwo-photon imagingViral transduction methodsNeuronal circuitsCalcium imagingMouse brainFunctional connectivityLocal microcircuitsMammalian cortexCortical architectureCortical networksBrainActivity propagates
2008
Mechanisms of response homeostasis during retinocollicular map formation
Shah RD, Crair MC. Mechanisms of response homeostasis during retinocollicular map formation. The Journal Of Physiology 2008, 586: 4363-4369. PMID: 18617562, PMCID: PMC2614012, DOI: 10.1113/jphysiol.2008.157222.Peer-Reviewed Original ResearchConceptsResponse homeostasisSynaptic plasticityIntrinsic excitabilityRetinocollicular map formationActivity-dependent developmentMouse superior colliculusHomeostatic plasticity mechanismsTotal synaptic inputReceptive fieldsDifferent mutant miceVisual receptive fieldsStrength of synapsesDifferent cellular mechanismsHebbian synaptic plasticityNeuronal outputSynaptic inputsSuperior colliculusRunaway excitationSynaptic scalingMutant miceNeural circuitsFunctional connectivityIndividual neuronsHomeostatic mechanismsCellular mechanisms