2024
Imaging Cardiac and Vascular Inflammation
Tavakoli S, Sadeghi M. Imaging Cardiac and Vascular Inflammation. 2024, 511-530. DOI: 10.1093/med/9780190095659.003.0025.Peer-Reviewed Original ResearchRisk stratification of patientsStratification of patientsPathogenesis of cardiovascular diseaseEvaluating cardiovascular pathologiesPrecision medicine toolsRisk stratificationClinical studiesEarly diagnosisInflammatory processCardiovascular diseaseMedicine toolsCardiovascular pathologyTherapeutic interventionsClinical settingImaging strategiesMolecular imagingImaging Cardiac and Vascular Inflammation
Tavakoli S, Sadeghi M. Imaging Cardiac and Vascular Inflammation. 2024, 131-133. DOI: 10.1093/med/9780197521434.003.0025.Peer-Reviewed Original ResearchRisk stratification of patientsStratification of patientsPathogenesis of cardiovascular diseaseEvaluating cardiovascular pathologiesPrecision medicine toolsRisk stratificationClinical studiesEarly diagnosisInflammatory processCardiovascular diseaseMedicine toolsCardiovascular pathologyTherapeutic interventionsClinical settingImaging strategiesMolecular imaging
2023
Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve
Ahmad A, Ghim M, Toczek J, Neishabouri A, Ojha D, Zhang Z, Gona K, Raza M, Jung J, Kukreja G, Zhang J, Guerrera N, Liu C, Sadeghi M. Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve. Journal Of Nuclear Medicine 2023, 64: 1487-1494. PMID: 37321825, PMCID: PMC10478817, DOI: 10.2967/jnumed.123.265516.Peer-Reviewed Original ResearchConceptsF-NaF PET/CTCalcific aortic valve diseaseBicuspid aortic valvePET/CTAortic valve calcificationAortic valve diseaseAortic valveAortic stenosisValve calcificationValvular calcificationValve diseaseF-NaFSubset of miceTricuspid aortic valveDevelopment of calcificationSignificant correlationUnderwent echocardiographyMedical therapyHigh prevalencePreclinical modelsMurine modelTherapeutic interventionsAge groupsAutoradiography dataMultimodality imaging
2018
Molecular imaging of calcific aortic valve disease
Jung JJ, Jadbabaie F, Sadeghi MM. Molecular imaging of calcific aortic valve disease. Journal Of Nuclear Cardiology 2018, 25: 1148-1155. PMID: 29359271, PMCID: PMC6054901, DOI: 10.1007/s12350-017-1158-7.Peer-Reviewed Original ResearchConceptsCalcific aortic valve diseaseAortic valve diseaseAortic stenosisValve diseaseSymptomatic aortic stenosisProgression of CAVDSubset of patientsRisk of complicationsMolecular imagingAsymptomatic patientsValvular calcificationDisease progressionFluoride PETTherapeutic interventionsClinical settingImaging protocolValvular biologyStenosisPatientsDiseaseCalcificationProgressionImagingEchocardiographyComplications
2016
Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology
Golestani R, Jung JJ, Sadeghi MM. Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology. Journal Of Clinical Medicine 2016, 5: 57. PMID: 27275836, PMCID: PMC4929412, DOI: 10.3390/jcm5060057.Peer-Reviewed Original ResearchVascular remodelingMolecular imaging techniquesPeripheral arterial diseaseSelection of patientsArt molecular imagingImaging techniquesVascular biology researchNuclear imaging techniquesMolecular imagingArterial diseaseRisk stratificationAortic aneurysmMyocardial ischemiaCardiovascular diseaseEarly diagnosisAnimal modelsCardiovascular pathologyTherapeutic interventionsCellular playersClinical toolKey mediatorAngiogenesisRemodelingClinical translationDisease
2014
Applications of Molecular Small-Animal Imaging in Cardiology
Marfatia R, Tavakoli S, Sadeghi M. Applications of Molecular Small-Animal Imaging in Cardiology. 2014, 547-584. DOI: 10.1007/978-1-4939-0894-3_20.Peer-Reviewed Original ResearchMagnetic resonance imagingCardiovascular diseaseImaging modalitiesPrevalence of CVDCourse of diseaseCVD mortality ratesMyocardial perfusion imagingConventional imaging modalitiesTraditional imaging modalitiesPrevention of diseaseDisease activityCoronary angiographyPrognostic informationLeading causeNovel therapiesMortality ratePerfusion imagingTherapeutic interventionsCellular eventsResonance imagingMolecular imaging modalitiesDiseaseEarly detectionTherapyHealth care
2013
Lipid lowering and imaging protease activation in atherosclerosis
Razavian M, Nie L, Challa A, Zhang J, Golestani R, Jung JJ, Robinson S, Sadeghi MM. Lipid lowering and imaging protease activation in atherosclerosis. Journal Of Nuclear Cardiology 2013, 21: 319-328. PMID: 24368425, PMCID: PMC3991560, DOI: 10.1007/s12350-013-9843-7.Peer-Reviewed Original ResearchConceptsHigh-fat dietLipid-lowering interventionsHFD groupPlaque inflammationAtherosclerotic miceMicroSPECT/CT imagingTotal blood cholesterolModern therapeutic approachesSmooth muscle αMMP tracerFat dietBlood cholesterolPlaque biologyTherapeutic approachesTracer uptakeMatrix metalloproteinaseTherapeutic interventionsAtherosclerosisActin expressionCT imagingMuscle αWeeksFenofibrateMiceIntervention