2023
Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve
Ahmad A, Ghim M, Toczek J, Neishabouri A, Ojha D, Zhang Z, Gona K, Raza M, Jung J, Kukreja G, Zhang J, Guerrera N, Liu C, Sadeghi M. Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve. Journal Of Nuclear Medicine 2023, 64: 1487-1494. PMID: 37321825, PMCID: PMC10478817, DOI: 10.2967/jnumed.123.265516.Peer-Reviewed Original ResearchConceptsF-NaF PET/CTCalcific aortic valve diseaseBicuspid aortic valvePET/CTAortic valve calcificationAortic valve diseaseAortic valveAortic stenosisValve calcificationValvular calcificationValve diseaseF-NaFSubset of miceTricuspid aortic valveDevelopment of calcificationSignificant correlationUnderwent echocardiographyMedical therapyHigh prevalencePreclinical modelsMurine modelTherapeutic interventionsAge groupsAutoradiography dataMultimodality imaging
2016
Novel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification
Toczek J, Meadows JL, Sadeghi MM. Novel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification. Circulation Cardiovascular Imaging 2016, 9: e003023. PMID: 26763279, PMCID: PMC4714781, DOI: 10.1161/circimaging.115.003023.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmRisk stratificationAortic aneurysmNovel molecular imaging approachesAbdominal aortic aneurysm repairFluorodeoxyglucose positron emission tomographyAortic aneurysm repairSelection of patientsPatient risk stratificationUltrasmall superparamagnetic particlesMagnetic resonance imagingMolecular imaging approachesAneurysm repairInflammatory cellsClinical trialsPreclinical modelsAneurysm sizeResonance imagingEmission tomographyAneurysm growthMatrix remodelingAneurysmsClinical translationMolecular imagingProteolytic enzymes