2024
Imaging Cardiac and Vascular Inflammation
Tavakoli S, Sadeghi M. Imaging Cardiac and Vascular Inflammation. 2024, 511-530. DOI: 10.1093/med/9780190095659.003.0025.Peer-Reviewed Original ResearchRisk stratification of patientsStratification of patientsPathogenesis of cardiovascular diseaseEvaluating cardiovascular pathologiesPrecision medicine toolsRisk stratificationClinical studiesEarly diagnosisInflammatory processCardiovascular diseaseMedicine toolsCardiovascular pathologyTherapeutic interventionsClinical settingImaging strategiesMolecular imagingImaging Cardiac and Vascular Inflammation
Tavakoli S, Sadeghi M. Imaging Cardiac and Vascular Inflammation. 2024, 131-133. DOI: 10.1093/med/9780197521434.003.0025.Peer-Reviewed Original ResearchRisk stratification of patientsStratification of patientsPathogenesis of cardiovascular diseaseEvaluating cardiovascular pathologiesPrecision medicine toolsRisk stratificationClinical studiesEarly diagnosisInflammatory processCardiovascular diseaseMedicine toolsCardiovascular pathologyTherapeutic interventionsClinical settingImaging strategiesMolecular imaging
2020
Accuracy of arterial [18F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study
Toczek J, Wu J, Hillmer AT, Han J, Esterlis I, Cosgrove KP, Liu C, Sadeghi MM. Accuracy of arterial [18F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study. Journal Of Nuclear Cardiology 2020, 27: 1578-1581. PMID: 32043239, PMCID: PMC7415600, DOI: 10.1007/s12350-020-02055-x.Peer-Reviewed Original ResearchConceptsMean SUVmaxMean TBRmaxFDG signalAortic wallMaximal standardized uptake valueD-glucose (FDG) PETVessel wall inflammationStandardized uptake valueActivity ex vivoPET imaging agentVascular inflammationWall inflammationRecent guidelinesBlood ratioCardiovascular diseasePrior historyPlasma activityTracer uptakeUptake valueSUVmaxTBRmaxEx vivoArterial wallVascular imagingFDG
2019
FDG PET imaging of vascular inflammation in post-traumatic stress disorder: A pilot case–control study
Toczek J, Hillmer AT, Han J, Liu C, Peters D, Emami H, Wu J, Esterlis I, Cosgrove KP, Sadeghi MM. FDG PET imaging of vascular inflammation in post-traumatic stress disorder: A pilot case–control study. Journal Of Nuclear Cardiology 2019, 28: 688-694. PMID: 31073848, PMCID: PMC6842076, DOI: 10.1007/s12350-019-01724-w.Peer-Reviewed Original ResearchConceptsFDG-PET imagingPost-traumatic stress disorderFDG signalSystemic inflammationVascular inflammationCardiovascular diseaseBone marrowPET imagingFDG PET/CT imagingPilot case-control studyStress disorderCardiovascular risk factorsInflammatory biomarker levelsHealthy control subjectsPET/CT imagingCase-control studyPositron emission tomography (PET) imagingEmission Tomography ImagingInflammatory biomarkersControl subjectsBlood glucoseRisk factorsBiomarker levelsHealthy controlsProspective group
2016
Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology
Golestani R, Jung JJ, Sadeghi MM. Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology. Journal Of Clinical Medicine 2016, 5: 57. PMID: 27275836, PMCID: PMC4929412, DOI: 10.3390/jcm5060057.Peer-Reviewed Original ResearchVascular remodelingMolecular imaging techniquesPeripheral arterial diseaseSelection of patientsArt molecular imagingImaging techniquesVascular biology researchNuclear imaging techniquesMolecular imagingArterial diseaseRisk stratificationAortic aneurysmMyocardial ischemiaCardiovascular diseaseEarly diagnosisAnimal modelsCardiovascular pathologyTherapeutic interventionsCellular playersClinical toolKey mediatorAngiogenesisRemodelingClinical translationDisease
2015
Cardiovascular Molecular Imaging
Morrison A, Wu J, Sadeghi M. Cardiovascular Molecular Imaging. 2015, 601-636. DOI: 10.1093/med/9780199392094.003.0029.Peer-Reviewed Original ResearchInterferon-&ggr;–Mediated Allograft Rejection Exacerbates Cardiovascular Disease of Hyperlipidemic Murine Transplant Recipients
Zhou J, Qin L, Yi T, Ali R, Li Q, Jiao Y, Li G, Tobiasova Z, Huang Y, Zhang J, Yun JJ, Sadeghi MM, Giordano FJ, Pober JS, Tellides G. Interferon-&ggr;–Mediated Allograft Rejection Exacerbates Cardiovascular Disease of Hyperlipidemic Murine Transplant Recipients. Circulation Research 2015, 117: 943-955. PMID: 26399469, PMCID: PMC4636943, DOI: 10.1161/circresaha.115.306932.Peer-Reviewed Original ResearchMeSH KeywordsAllograftsAnimalsAortic DiseasesApolipoproteins EAtherosclerosisCardiomyopathiesCardiovascular DiseasesDisease Models, AnimalFemaleGraft RejectionHeart TransplantationHemodynamicsHistocompatibility Antigens Class IIHyperlipidemiasInflammation MediatorsInterferon-gammaLymphocyte ActivationMaleMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutSignal TransductionTh1 CellsVentricular Dysfunction, LeftVentricular Function, LeftConceptsOrgan transplant recipientsCardiovascular diseaseTransplant recipientsEarly-onset cardiovascular diseaseEnd-stage organ failureNative coronary arteriesTh1-type cytokinesT helper cellsHost diseaseAlloimmune responseGraft rejectionAortic stiffeningOrgan failureVentricular dilatationAllogeneic graftsCardiovascular dysfunctionCoronary arteryAortic complianceRisk factorsEffective therapyCardiac contractilityMurine modelAnimal modelsSerological neutralizationImmune systemMHC class II-disparate heart but not skin allografts accelerate recipient cardiovascular disease (TRAN1P.934)
Zhou J, yi T, Qin L, Ali R, Li Q, Jiao Y, Li G, Zhang J, Sadeghi M, Pober J, Tellides G. MHC class II-disparate heart but not skin allografts accelerate recipient cardiovascular disease (TRAN1P.934). The Journal Of Immunology 2015, 194: 140.16-140.16. DOI: 10.4049/jimmunol.194.supp.140.16.Peer-Reviewed Original ResearchSkin allograftsCardiovascular diseaseAllograft rejectionCardiac allograftsHeart allograftsDonor miceSkin graftsMHC classAtherosclerotic lesionsApoE-/- mouse modelEarly activation marker CD69End-stage organ failureCD4 T cellsWeeks post transplantationActivation marker CD69Larger atherosclerotic lesionsHeart isograftsCardiac isograftsOrgan failurePost transplantationIL-12ACardiac functionElevated mRNA levelsEffective therapyOrgan transplantation
2014
Applications of Molecular Small-Animal Imaging in Cardiology
Marfatia R, Tavakoli S, Sadeghi M. Applications of Molecular Small-Animal Imaging in Cardiology. 2014, 547-584. DOI: 10.1007/978-1-4939-0894-3_20.Peer-Reviewed Original ResearchMagnetic resonance imagingCardiovascular diseaseImaging modalitiesPrevalence of CVDCourse of diseaseCVD mortality ratesMyocardial perfusion imagingConventional imaging modalitiesTraditional imaging modalitiesPrevention of diseaseDisease activityCoronary angiographyPrognostic informationLeading causeNovel therapiesMortality ratePerfusion imagingTherapeutic interventionsCellular eventsResonance imagingMolecular imaging modalitiesDiseaseEarly detectionTherapyHealth care
2011
Age-Related Macular Degeneration and Incident Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis
Fernandez AB, Wong TY, Klein R, Collins D, Burke G, Cotch MF, Klein B, Sadeghi MM, Chen J. Age-Related Macular Degeneration and Incident Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis. Ophthalmology 2011, 119: 765-770. PMID: 22197438, PMCID: PMC3314126, DOI: 10.1016/j.ophtha.2011.09.044.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationIncident coronary heart diseaseCoronary heart diseaseEarly age-related macular degenerationRisk of CHDCVD eventsMulti-Ethnic StudyRisk factorsMacular degenerationLate age-related macular degenerationNon-AMD groupCVD risk factorsCardiovascular disease eventsIncident cardiovascular diseaseProspective cohort studyHistory of CVDCox regression modelMulti-ethnic cohortMean followCohort studyRetinal photographsClinical followHeart diseaseCardiovascular diseaseDisease events