2021
Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder
Yadav S, Bhat A, Hashem S, Nisar S, Kamal M, Syed N, Temanni M, Gupta R, Kamran S, Azeem M, Srivastava A, Bagga P, Chawla S, Reddy R, Frenneaux M, Fakhro K, Haris M. Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder. Translational Psychiatry 2021, 11: 349. PMID: 34091591, PMCID: PMC8179928, DOI: 10.1038/s41398-021-01473-w.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAttention Deficit Disorder with HyperactivityBrainChildGenetic Predisposition to DiseaseGenetic VariationHumansNeuroimagingConceptsAttention deficit hyperactivity disorderNeurobiology of ADHDHyperactivity disorderSevere brain injuryNew treatment modalitiesDevelopment of ADHDBrain circuit functionNovel clinical biomarkersChildhood-onset disordersStrong genetic associationNeurodevelopmental assessmentPremature birthADHD brainTreatment modalitiesBrain injuryBrain changesPrecise etiologyPsychiatric disordersAnimal modelsADHD patientsTherapeutic interventionsNeural abnormalitiesClinical biomarkersNeurodevelopmental issuesSignificant association
2014
Comparing stimulant effects in youth with ADHD symptoms and epilepsy
Gonzalez-Heydrich J, Hsin O, Gumlak S, Kimball K, Rober A, Azeem MW, Hickory M, Mrakotsky C, Torres A, Mezzacappa E, Bourgeois B, Biederman J. Comparing stimulant effects in youth with ADHD symptoms and epilepsy. Epilepsy & Behavior 2014, 36: 102-107. PMID: 24907495, PMCID: PMC4109643, DOI: 10.1016/j.yebeh.2014.04.026.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmphetamineAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildCognitionElectroencephalographyEpilepsyFemaleHumansMaleMethylphenidateNeuropsychological TestsRetrospective StudiesSeverity of Illness IndexConceptsSeizure freedomADHD symptomsCGI improvement scoreImproved treatment outcomesHigh response rateUse of methylphenidateStart of trialMedication trialsMedical recordsUncontrolled designTreatment outcomesTreatment responseStimulant treatmentStimulant effectsPatientsResponse rateSeizuresMethylphenidateAmphetamine preparationsEmotional labilityBaseline frequencyEpilepsyAdverse effectsSymptomsTrials