2023
Nicotine addiction: More than just dopamine
Kim K, Picciotto M. Nicotine addiction: More than just dopamine. Current Opinion In Neurobiology 2023, 83: 102797. PMID: 37832393, PMCID: PMC10842238, DOI: 10.1016/j.conb.2023.102797.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNicotine addictionImportant public health problemAnti-tobacco messagingNicotine-induced behaviorsPublic health problemReward-related behaviorsNovel glutamateDopaminergic mechanismsSmoking cessationNicotine reinforcementMesolimbic systemNicotine seekingRecent studiesTherapeutic targetNicotine aversionHealth problemsActive investigationAdditional pathwaysSex differencesNicotine vapingMolecular mechanismsWithdrawalAddictionPathwayMolecular basis
2001
Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications
Picciotto M, Caldarone B, Brunzell D, Zachariou V, Stevens T, King S. Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications. Pharmacology & Therapeutics 2001, 92: 89-108. PMID: 11916531, DOI: 10.1016/s0163-7258(01)00161-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSignal transduction pathwaysHomologous recombinationTransduction pathwaysGenetic manipulationMolecular basisBehavioral phenotypesInactivation of nAChRsNicotinic acetylcholine receptorsSubunit compositionSubunitsNeuronal nicotinic receptorsPersistent activationNeurotransmitter releaseRelevant mutationsModel systemPossible clinical implicationsPhysiological propertiesAcetylcholine receptorsPhenotypeAutonomic gangliaNicotinic receptorsDisease statesDrug developmentPharmacological actionsNAChRs